Results 41 to 50 of about 2,664 (183)
Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding
Journal of Molecular Biology, 2023 Transferrin receptor 1 (TfR) delivers iron across cellular membranes by shuttling the ion carrier protein transferrin. This ability to deliver large protein ligands inside cells is taken advantage of by pathogens to infiltrate human cells. Notably, the receptor's outermost ectodomain, the apical domain, is used as a point of attachment for several ...
Sjöström, Dick J. +7 more
openaire +3 more sources
Nature Communications, 2018 The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo ...
Lars E. Clark +12 more
doaj +1 more source
Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production
Frontiers in Microbiology, 2020 Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo +6 more
doaj +1 more source
Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses
Journal of Infection and Public Health, 2023 Background: Multiplex real-time PCR is a quick and cost effective method for detection of various gene simultaneously. HFSV (Hemorrhagic Fever Syndrome Virus) is a newly emerging infectious disease because of globalization and climate change. We tried to
Yoonhyuk Choi, Younghee Kim
doaj +1 more source
A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease. [PDF]
, 2016 UNLABELLED: Arenaviruses are emerging viruses including several causative agents of severe hemorrhagic fevers in humans. The advent of next-generation sequencing technology has greatly accelerated the discovery of novel arenavirus species.
Bergeron, E. +7 more
core +1 more source
Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses
Vaccines, 2019 The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo +2 more
doaj +1 more source
A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.
PLoS Neglected Tropical Diseases, 2020 Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence ...
Steven J Hallam +7 more
doaj +1 more source
Heliyon, 2021 Arenaviral infections often result lethal hemorrhagic fevers, affecting primarily in African and South American regions. To date, there is no FDA-approved licensed vaccine against arenaviruses and treatments have been limited to supportive therapy. Hence,
Kazi Faizul Azim +6 more
doaj +1 more source
Co-infecting Reptarenaviruses Can Be Vertically Transmitted in Boa Constrictor [PDF]
, 2017 Boid inclusion body disease (BIBD) is an often fatal disease affecting mainly constrictor snakes. BIBD has been associated with infection, and more recently with coinfection, by various reptarenavirus species (family Arenaviridae). Thus far BIBD has only
Hepojoki, Jussi +6 more
core +2 more sources
Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses
mSphere, 2018 Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat +5 more
doaj +1 more source