Results 41 to 50 of about 1,040,510 (176)
Structural Polypeptides of Machupo Virus
Journal of General Virology, 1978 The structural proteins of an arenavirus pathogen, Machupo virus, were compared to the structural proteins of two previously characterized non-pathogenic arenaviruses, Pichinde and Tacaribe, in SDS-polyacrylamide gels. Similarities in mol. wt. of the major structural proteins from both pathogenic and non-pathogenic viruses were apparent; however, some ...
J D, Gangemi +4 more
openaire +2 more sources
Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic. [PDF]
J Virol, 2016 ABSTRACT Machupo virus (MACV) is the causative agent of Bolivian hemorrhagic fever. Our previous study demonstrated that a MACV strain with a single amino acid substitution (F438I) in the transmembrane domain of glycoprotein is attenuated but genetically unstable in mice.
Koma T +9 more
europepmc +4 more sources
Computational backbone design enables soluble engineering of transferrin receptor apical domain
Proteins: Structure, Function, and Bioinformatics, Volume 88, Issue 12, Page 1569-1577, December 2020., 2020 Abstract Supply of iron into human cells is achieved by iron carrier protein transferrin and its receptor that upon complex formation get internalized by endocytosis. Similarly, the iron needs to be delivered into the brain, and necessitates the transport across the blood‐brain barrier. While there are still unanswered questions about these mechanisms,
Dick J. Sjöström +3 more
wiley +1 more source
Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes
Cellular Microbiology, Volume 22, Issue 1, January 2020., 2020 Abstract Plasmodium vivax is responsible for most of the malaria infections outside Africa and is currently the predominant malaria parasite in countries under elimination programs. P. vivax preferentially enters young red cells called reticulocytes. Advances in understanding the molecular and cellular mechanisms of entry are hampered by the inability ...
Li‐Jin Chan +3 more
wiley +1 more source
Chemical Physics Impact, 2023 The current work is concerned with the theoretical discernment of adsorption processes between the Furo [3,2-c] pyridine-2-carbaldehyde and bimetallic clusters (Cu-Ag, Cu-Au and Cu-Ni).
Sravanthi R +5 more
doaj +1 more source
Nature Communications, 2018 The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo ...
Lars E. Clark +12 more
doaj +1 more source
Measurement of Antibodies to Machupo Virus by the Indirect Fluorescent Technique
Experimental Biology and Medicine, 1973 Bolivian hemorrhagic fever (BHF) was first recognized in the Province of Beni, Bolivia, in 1959 (1), and cases have continued to occur since then. Recent outbreaks have confirmed the fact that clinical manifestations can be quite nonspecific. Laboratory diagnosis is handicapped by a scarcity of facilities in the endemic region, as well as by the hazard
C J, Peters, P A, Webb, K M, Johnson
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Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses
Journal of Infection and Public Health, 2023 Background: Multiplex real-time PCR is a quick and cost effective method for detection of various gene simultaneously. HFSV (Hemorrhagic Fever Syndrome Virus) is a newly emerging infectious disease because of globalization and climate change. We tried to
Yoonhyuk Choi, Younghee Kim
doaj +1 more source
Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production
Frontiers in Microbiology, 2020 Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo +6 more
doaj +1 more source
Vaccines for emerging pathogens: prospects for licensure
Clinical &Experimental Immunology, Volume 198, Issue 2, Page 170-183, November 2019., 2019 This review covers the global incidence of disease caused by emerging and re‐emerging pathogens and the availability of vaccines for these. It considers the hurdles to be overcome to achieve comprehensive vaccine coverage and reviews the regulatory mechanisms which may be available to seek approval for human use in emergency situations.
E. D. Williamson, G. E. Westlake
wiley +1 more source