Results 31 to 40 of about 2,664 (183)
Application of spectral library prediction for parallel reaction monitoring of viral peptides
PROTEOMICS, Volume 21, Issue 7-8, April 2021., 2021 Abstract A major part of the analysis of parallel reaction monitoring (PRM) data is the comparison of observed fragment ion intensities to a library spectrum. Classically, these libraries are generated by data‐dependent acquisition (DDA). Here, we test Prosit, a published deep neural network algorithm, for its applicability in predicting spectral ...
Marica Grossegesse +3 more
wiley +1 more source
mBio, 2022 Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng +9 more
doaj +1 more source
Frontiers in Microbiology, 2021 Ebola virus infection causes severe hemorrhagic fever, and its mortality rates varied from 25 to 90% in the previous outbreaks. The highly infectious and lethal nature of this virus highlights the need for reliable and sensitive diagnostic methods to ...
Wenwu Yao +5 more
doaj +1 more source
PLoS Pathogens, 2021 Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old ...
Nicolás Sarute +6 more
doaj +1 more source
Coronavirus in human diseases: Mechanisms and advances in clinical treatment
MedComm, Volume 1, Issue 3, Page 270-301, December 2020., 2020 Current mechanisms of anti‐CoV therapeutic strategies. The idea to disturb the normal life cycle of the virus provides significant insights into the clinical treatment strategies. All of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 encode structure proteins (like S protein), nonstructure proteins (eg, PLpro, 3CLpro, RdRp, and helicase), and accessory proteins ...
Panpan Lin +4 more
wiley +1 more source
Structural Polypeptides of Machupo Virus
Journal of General Virology, 1978 The structural proteins of an arenavirus pathogen, Machupo virus, were compared to the structural proteins of two previously characterized non-pathogenic arenaviruses, Pichinde and Tacaribe, in SDS-polyacrylamide gels. Similarities in mol. wt. of the major structural proteins from both pathogenic and non-pathogenic viruses were apparent; however, some ...
J D, Gangemi +4 more
openaire +2 more sources
Computational backbone design enables soluble engineering of transferrin receptor apical domain
Proteins: Structure, Function, and Bioinformatics, Volume 88, Issue 12, Page 1569-1577, December 2020., 2020 Abstract Supply of iron into human cells is achieved by iron carrier protein transferrin and its receptor that upon complex formation get internalized by endocytosis. Similarly, the iron needs to be delivered into the brain, and necessitates the transport across the blood‐brain barrier. While there are still unanswered questions about these mechanisms,
Dick J. Sjöström +3 more
wiley +1 more source
Chemical Physics Impact, 2023 The current work is concerned with the theoretical discernment of adsorption processes between the Furo [3,2-c] pyridine-2-carbaldehyde and bimetallic clusters (Cu-Ag, Cu-Au and Cu-Ni).
Sravanthi R +5 more
doaj +1 more source
Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic. [PDF]
J Virol, 2016 ABSTRACT Machupo virus (MACV) is the causative agent of Bolivian hemorrhagic fever. Our previous study demonstrated that a MACV strain with a single amino acid substitution (F438I) in the transmembrane domain of glycoprotein is attenuated but genetically unstable in mice.
Koma T +9 more
europepmc +4 more sources
Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes
Cellular Microbiology, Volume 22, Issue 1, January 2020., 2020 Abstract Plasmodium vivax is responsible for most of the malaria infections outside Africa and is currently the predominant malaria parasite in countries under elimination programs. P. vivax preferentially enters young red cells called reticulocytes. Advances in understanding the molecular and cellular mechanisms of entry are hampered by the inability ...
Li‐Jin Chan +3 more
wiley +1 more source