Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model. [PDF]
PLoS Neglected Tropical DiseasesBackgroundMachupo virus (MACV) is a New World mammarenavirus (hereafter referred to as "arenavirus") and the etiologic agent of Bolivian hemorrhagic fever (BHF).
Emily Mantlo +5 more
doaj +3 more sources
Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus. [PDF]
J Virol, 2021 Arenaviruses are rodent-borne pathogens that can cause severe disease in humans. All arenaviruses begin the infection cycle with delivery of the virus replication machinery into the cytoplasm of the host cell.
Pyle JD, Whelan SPJ.
europepmc +4 more sources
A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of Machupo virus. [PDF]
J Virol, 2014 ABSTRACT Machupo virus (MACV) is the etiologic agent of Bolivian hemorrhagic fever (BHF). Utilizing a reverse-genetics system recently developed, we report the rescue of a rationally modified recombinant MACV containing a single mutation in the transmembrane region of the glycoprotein.
Patterson M +8 more
europepmc +4 more sources
Machupo Virus with Mutations in the Transmembrane Domain and Glycosylation Sites of the Glycoprotein Is Attenuated and Immunogenic in Animal Models of Bolivian Hemorrhagic Fever. [PDF]
J Virol, 2022 Mantlo EK +8 more
europepmc +3 more sources
An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection [PDF]
Scientific Reports, 2017 Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car91 that was attenuated in guinea pigs.
Joseph W. Golden +6 more
doaj +2 more sources
The History of Machupo Virus in Bolivia: Arenavirus Hemorrhagic Fever
, 2018 Yambuku is what the Africans called the Ebola virus that struck hundreds of victims in Sub-Sahara Africa in 1993 and received so much notoriety in the American news media. What most people do not know is that an outbreak of a "sister" virus to Ebola occurred in a small community in the Amazon Basin in Bolivia about one year later. Similar to its deadly
Tiffany Y. Strauchs
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A STAT1-Knockout Mouse Model for Chapare Virus Infection and Pathogenesis [PDF]
VirusesChapare virus (CHAPV) is an Arenaviridae family member and causative agent of Chapare hemorrhagic fever (CHHF). Endemic to Bolivia, CHAPV was found to be the cause of several outbreaks of CHHF in Bolivia in 2003 and 2019 with high case-fatality rates and
Stephanie R. Monticelli +12 more
doaj +2 more sources
Morphological Comparison of Machupo with Lymphocytic Choriomeningitis Virus: Basis for a New Taxonomic Group [PDF]
Journal of Virology, 1969 Striking morphologic similarities between Machupo, Tacaribe, and lymphocytic choriomeningitis viruses were found by thin-section electron microscopy. It is proposed that these viruses be brought together into a single taxonomic group.
Frederick A. Murphy +3 more
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High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle [PDF]
SLAS DiscoverySARS-CoV-2 and other related viruses enter host cells via receptor recognition and membrane fusion. A crucial part of this is mediated by 5HB which is capable of binding to the viral spike heptad repeats (HR2) making 5HB a potential druggable target of ...
Emery Smith +6 more
doaj +2 more sources
Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice. [PDF]
J Virol, 2014 Patterson M +12 more
europepmc +3 more sources