Results 51 to 60 of about 1,040,510 (176)

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

mSphere, 2018
Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M. Hastie, Erica Ollmann Saphire, Florian Krammer   +5 more
doaj   +1 more source

Combination of highly antigenic nucleoproteins to inaugurate a cross-reactive next generation vaccine candidate against Arenaviridae family

Heliyon, 2021
Arenaviral infections often result lethal hemorrhagic fevers, affecting primarily in African and South American regions. To date, there is no FDA-approved licensed vaccine against arenaviruses and treatments have been limited to supportive therapy. Hence,
Kazi Faizul Azim, Tahera Lasker, Rahima Akter, Mantasha Mahmud Hia, Omar Faruk Bhuiyan, Mahmudul Hasan, Md Nazmul Hossain   +6 more
doaj   +1 more source

The HIV glycan shield as a target for broadly neutralizing antibodies

The FEBS Journal, Volume 282, Issue 24, Page 4679-4691, December 2015., 2015
The HIV envelope glycoprotein, Env, is extensively decorated with host‐derived N‐linked glycans. These glycans not only shield conserved protein regions from antibody recognition but, critically, act as epitopes for some of the most broad and potent neutralizing antibodies.
Katie J. Doores
wiley   +1 more source

Machupo virus GP1 mutants.

, 2013
Top panel, sequence alignment of New World clade B arenaviruses. Sequence alignment of Machupo virus (MACV) GP1 residues 108–229 with Junín virus (JUNV), Chapare virus (CHPV), Tacaribe virus (TCRV), Guanarito virus (GTOV), Amapari virus (AMAV) and Sabiá ...
Sina Bavari (154739), Cary Retterer (348525), Jeremiah C. Clester (348526), John Carra (348528), Lian Dong (233648), Sheli R. Radoshitzky (233641), Jens H. Kuhn (200537), Krishna Kota (348527), Lindsay E. Longobardi (233649)   +8 more
core   +1 more source

A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.

PLoS Neglected Tropical Diseases, 2020
Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence ...
Steven J Hallam, John T Manning, Junki Maruyama, Alexey Seregin, Cheng Huang, David H Walker, Juan Carlos de la Torre, Slobodan Paessler   +7 more
doaj   +1 more source

Animal Models for the Study of Rodent‐Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Human pathogenic hantaviruses and arenaviruses are maintained in nature by persistent infection of rodent carrier populations. Several members of these virus groups can cause significant disease in humans that is generically termed viral hemorrhagic fever (HF) and is characterized as a febrile illness with an increased propensity to cause acute ...
Joseph W. Golden, Christopher D. Hammerbeck, Eric M. Mucker, Rebecca L. Brocato, Kevin M. Coombs   +4 more
wiley   +1 more source

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Multiplex Degenerate Primer Design for Targeted Whole Genome Amplification of Many Viral Genomes

Advances in Bioinformatics, Volume 2014, Issue 1, 2014., 2014
Background. Targeted enrichment improves coverage of highly mutable viruses at low concentration in complex samples. Degenerate primers that anneal to conserved regions can facilitate amplification of divergent, low concentration variants, even when the strain present is unknown. Results.
Shea N. Gardner, Crystal J. Jaing, Maher M. Elsheikh, José Peña, David A. Hysom, Monica K. Borucki, Paul Harrison   +6 more
wiley   +1 more source

Family‐Specific Degenerate Primer Design: A Tool to Design Consensus Degenerated Oligonucleotides

Biotechnology Research International, Volume 2013, Issue 1, 2013., 2013
Designing degenerate PCR primers for templates of unknown nucleotide sequence may be a very difficult task. In this paper, we present a new method to design degenerate primers, implemented in family‐specific degenerate primer design (FAS‐DPD) computer software, for which the starting point is a multiple alignment of related amino acids or nucleotide ...
Javier Alonso Iserte, Betina Ines Stephan, Sandra Elizabeth Goñi, Cristina Silvia Borio, Pablo Daniel Ghiringhelli, Mario Enrique Lozano, Goetz Laible   +6 more
wiley   +1 more source

Arenavirus Budding

Advances in Virology, Volume 2011, Issue 1, 2011., 2011
Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus‐host interactions and associated disease.
Shuzo Urata, Juan Carlos de la Torre, Fadila Bouamr   +2 more
wiley   +1 more source