Results 51 to 60 of about 2,664 (183)
Vaccines for emerging pathogens: prospects for licensure
Clinical &Experimental Immunology, Volume 198, Issue 2, Page 170-183, November 2019., 2019 This review covers the global incidence of disease caused by emerging and re‐emerging pathogens and the availability of vaccines for these. It considers the hurdles to be overcome to achieve comprehensive vaccine coverage and reviews the regulatory mechanisms which may be available to seek approval for human use in emergency situations.
E. D. Williamson, G. E. Westlake
wiley +1 more source
Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage [PDF]
, 2010 Background Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Arenaviridae family.
Maya F Kotturi +12 more
core +2 more sources
The HIV glycan shield as a target for broadly neutralizing antibodies
The FEBS Journal, Volume 282, Issue 24, Page 4679-4691, December 2015., 2015 The HIV envelope glycoprotein, Env, is extensively decorated with host‐derived N‐linked glycans. These glycans not only shield conserved protein regions from antibody recognition but, critically, act as epitopes for some of the most broad and potent neutralizing antibodies.
Katie J. Doores
wiley +1 more source
Measurement of Antibodies to Machupo Virus by the Indirect Fluorescent Technique
Experimental Biology and Medicine, 1973 Bolivian hemorrhagic fever (BHF) was first recognized in the Province of Beni, Bolivia, in 1959 (1), and cases have continued to occur since then. Recent outbreaks have confirmed the fact that clinical manifestations can be quite nonspecific. Laboratory diagnosis is handicapped by a scarcity of facilities in the endemic region, as well as by the hazard
C J, Peters, P A, Webb, K M, Johnson
openaire +2 more sources
Animal Models for the Study of Rodent‐Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Human pathogenic hantaviruses and arenaviruses are maintained in nature by persistent infection of rodent carrier populations. Several members of these virus groups can cause significant disease in humans that is generically termed viral hemorrhagic fever (HF) and is characterized as a febrile illness with an increased propensity to cause acute ...
Joseph W. Golden +4 more
wiley +1 more source
Multiplex Degenerate Primer Design for Targeted Whole Genome Amplification of Many Viral Genomes
Advances in Bioinformatics, Volume 2014, Issue 1, 2014., 2014 Background. Targeted enrichment improves coverage of highly mutable viruses at low concentration in complex samples. Degenerate primers that anneal to conserved regions can facilitate amplification of divergent, low concentration variants, even when the strain present is unknown. Results.
Shea N. Gardner +6 more
wiley +1 more source
Hematology Reports, 2020 World Health Organization (WHO) declared coronavirus disease (COVID-19) a pandemic in March 2020. Currently almost every country in the world has reported cases with moderate to high mortality rates. The European Union (EU), the United States of America (
Seidu A. Richard +2 more
doaj +1 more source
Interaction of silver nanoparticles with Tacaribe virus [PDF]
, 2010 Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is ...
Janice L Speshock +4 more
core +2 more sources
Comparison of Vaccine Platforms for Machupo Virus
VaccinesBackground/Objectives: Pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans. Machupo virus (MACV), a New World (NW) mammarenavirus, causes Bolivian hemorrhagic fever in humans, and there are no approved vaccines. Methods:
Rachel Erickson +6 more
doaj +1 more source
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression [PDF]
, 2017 Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the
Alexey V. Seregin +7 more
core +1 more source