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Advances in Virology, Volume 2011, Issue 1, 2011., 2011 Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus‐host interactions and associated disease.
Shuzo Urata +2 more
wiley +1 more source
Urgent pandemic messaging of WHO, World Bank, and G20 is inconsistent with their evidence base
Global Policy, Volume 15, Issue 4, Page 689-707, September 2024.Abstract When international agencies make claims of an “existential threat” to humanity and advocate for urgent action from countries, it should be a safe assumption that they are consistent with their own data. However, a review of the data and evidentiary citations underlying the claims of the World Health Organization (WHO), the World Bank, and the ...
David Bell +3 more
wiley +1 more source
Expression and Purification of Z Protein from Junín Virus
BioMed Research International, Volume 2010, Issue 1, 2010., 2010 Arenaviridae comprises 23 recognized virus species with a bipartite ssRNA genome and an ambisense coding strategy. The virions are enveloped and include nonequimolar amounts of each genomic RNA species, designated L and S, coding for four ORFs (N, GPC, L, and Z).
S. E. Goñi +11 more
wiley +1 more source
Virions at the gates: receptors and the host-virus arms race. [PDF]
PLoS Biology, 2013 All viruses need to bind to specific receptor molecules on the surface of target cells to initiate infection. Virus-receptor binding is highly specific, and this specificity determines both the species and the cell type that can be infected by a given ...
John M Coffin
doaj +1 more source
Ifitm3 Limits the Severity of Acute Influenza in Mice [PDF]
, 2012 Interferon-induced transmembrane (IFITM) proteins are a family of viral restriction factors that inhibit the entry processes of several pathogenic viruses, including influenza A virus (IAV), in vitro.
Bailey, Charles C +3 more
core +7 more sources
Rapid Sequence Identification of Potential Pathogens Using Techniques from Sparse Linear Algebra
, 2015 The decreasing costs and increasing speed and accuracy of DNA sample collection, preparation, and sequencing has rapidly produced an enormous volume of genetic data. However, fast and accurate analysis of the samples remains a bottleneck. Here we present
Chiu, Nelson +4 more
core +1 more source
Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity.
PLoS Pathogens, 2021 Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina.
Takaaki Koma +11 more
doaj +1 more source
South American Hemorrhagic Fevers: A summary for clinicians
International Journal of Infectious Diseases, 2021 Objectives: This article is one of a series on acute, severe diseases of humans caused by emerging viruses for which there are no or limited licensed medical countermeasures.
Maria G. Frank +22 more
doaj +1 more source
, 2006 Terrorism preparedness is a highly specific component of general emergency preparedness. In addition to the unique pediatric issues involved in general emergency preparedness, terrorism preparedness must consider several additional issues, including the ...
Markenson, David, Redlener, Irwin E.
core +2 more sources
Animal Models of Pathogenic New World Arenaviruses
MicroorganismsSince the emergence of Junín virus in 1953, pathogenic New World arenaviruses have remained a public health concern. These viruses, which also include Machupo virus, Guanarito virus, Sabiá virus, and Chapare virus, cause acute viral hemorrhagic fever and
Alexander V. Alvarado +3 more
doaj +1 more source