Results 201 to 210 of about 9,528 (245)

Macrocyclic Proteasome Inhibitors

Current Medicinal Chemistry, 2011
Proteasome inhibitors have proven to be effective anticancer agents. Despite the success of the first on the market proteasome inhibitor bortezomib in chemotherapy, alternative clinically useful proteasome inhibitors are still urgently needed as bortezomib therapy causes severe side effects and is limited by arising drug resistance.
Krahn, D., Ottmann, C., Kaiser, Markus
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Application of Ruthenium-Induced Macrocyclization for the Construction of Macrocyclic Depsipeptides

The Journal of Organic Chemistry, 2002
The synthesis of a biaryl ether containing macrocyclic depsipeptide 1 was achieved in 6% overall yield. The desired macrocycle was constructed by cyclization of a phenol into eta(6)-ruthenium complex. The ruthenium metal was subsequently photolytically deprotected to obtain the macrocycle 1.
Srikanth, Venkatraman, F George, Njoroge, Viyyoor, Girijavallabhan, Andrew T, McPhail   +3 more
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Modulation by macrocyclic peptides

Science Signaling, 2022
Cell-permeable, macrocyclic peptides antagonize either the active or the inactive states of Gα s to fine-tune signaling.
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Reply to: Macrocyclic colibactins

Nature Chemistry, 2020
Herzon, S. B. Macrocyclic colibactins. Nat. Chem. https://doi.org/10.1038/s41557-020-00551-8 (2020). Li, Z.-R. et al. Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nat. Chem. 11, 880–889 (2019).
Wenjun Zhang, Pei-Yuan Qian
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Metamorphosis of Tetrapyrrole Macrocycles

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mathias O, Senge, Natalia N, Sergeeva
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Resistance to Macrocyclic Lactones

Current Pharmaceutical Biotechnology, 2012
Resistance to the macrocyclic lactones (MLs) has been confirmed or suspected in many target organisms and is a serious problem in some. For some species, such as parasitic nematodes of small ruminants, ML resistance has become severe enough to threaten effective worm control worm control.
Adrian J, Wolstenholme, Ray M, Kaplan
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BODIPY-based macrocycles

Chemical Society Reviews, 2020
This review comprehensively summarized the construction of BODIPY-based macrocycles and their properties as well as applications.
Yi Qin, Xi Liu, Pei-Pei Jia, Lin Xu, Hai-Bo Yang   +4 more
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Multicavity macrocyclic hosts

Chemical Communications, 2016
Multicavity macrocyclic hosts are host molecules comprising more than one macrocyclic guest binding components connected through multipoint linkages.
Wei-Bo, Hu, Wen-Jing, Hu, Yahu A, Liu, Jiu-Sheng, Li, Biao, Jiang, Ke, Wen   +5 more
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Macrocyclic Polyethers and Their Complexes

Angewandte Chemie International Edition in English, 1972
AbstractThe most important, and almost unique, property of the macrocyclic polyethers (“crown compounds”) is their tendency to form complexes with alkali metal salts and salts with similar cations. Such complexes are held together by electrostatic attraction between the cation and the negative end of the CO dipoles.
C J, Pedersen, H K, Frensdorff
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Macrocyclic phosphazane ligands

Dalton Transactions, 2010
Inorganic macrocycles based on P(III)–N bonded frameworks can be obtained by a series of systematic routes, many of which parallel those commonly employed in the synthesis of more well known organic relatives. Such phosph(III)azane macrocycles exhibit a broad range of coordination behaviour, and provide new organically-soluble hosts, with unique steric
Silvia Gonzalez, Calera, Dominic S, Wright   +1 more
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