Acta Crystallographica Section F, EarlyView.Structural and binding studies of the engineered lipocalin CL31d towards the chelate complexes of 11 different lanthanide and main‐group metal(III) ions, whose radioisotopes are useful for nuclear medicine, with a functionalized DTPA revealed a surprisingly broad tolerance towards varying ionic radii, thus enabling flexible radionuclide‐targeting ...
Alina Mirwald +2 more
wiley +1 more source
Anion Binding by Macrocyclic Receptors: Computational Landscape of 1:1 and 2:1 Stoichiometries. [PDF]
J Comput ChemChe M, Flood AH, Raghavachari K.
europepmc +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Beyond Passive Substituents: Tosyl-Directed Self-Templation Enables Selective Pillar[4 + 1]arene Formation and Topology Switching. [PDF]
J Am Chem SocRuengsuk A +8 more
europepmc +1 more source
Photochemistry and Photobiology, EarlyView.Photoproducts of the photosensitizer protoporphyrin IX (PpIX) may have diagnostic and therapeutic relevance in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These photoproducts possess fluorescence and photosensitizing properties and could serve as a complementary dosimetry index alongside photosensitizer photobleaching. The formation of
Sochi J. Ogbonna +2 more
wiley +1 more source
Design and synthesis of macrocycles with tuneable diameters and helical foldamers with customizable peripheral side chains. [PDF]
Chem SciFarooq S, Crochet A, Kilbinger AFM.
europepmc +1 more source
Advances in organic UV filters for sunscreens over the past decade
Photochemistry and Photobiology, EarlyView.Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon +4 more
wiley +1 more source
Inherently chiral homo-heteracalixarenes: design and synthesis <i>via</i> an enantioselective intramolecular Sonogashira cross-coupling reaction. [PDF]
Chem SciJiang YF +4 more
europepmc +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
A Competing Hydrogen Bond Network Offers Access to a New Conformation in 24-Atom Triazine Macrocycles. [PDF]
MoleculesReddy KHV +3 more
europepmc +1 more source