Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)* [PDF]
, 2016 Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways.
Ashley, Jason W +7 more
core +4 more sources
MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation. [PDF]
PLoS ONE, 2015 Macrophages dictate both initiation and resolution of inflammation. During acute inflammation classically activated macrophages (M1) predominate, and during the resolution phase alternative macrophages (M2) are dominant. The molecular mechanisms involved
Zhuo Wang +6 more
doaj +6 more sources
Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells [PDF]
Brazilian Journal of Medical and Biological Research, 2020 Macrophages play pivotal roles in host defense and immune homeostasis, which have two major functional polarization states, the classically activated M1 and the alternatively activated M2.
Chao Yuan +6 more
doaj +1 more source
Macrophage Polarity and Disease Control [PDF]
International Journal of Molecular Sciences, 2021 Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals.
Suguru Kadomoto +2 more
openaire +2 more sources
Ironing Out the Details: How Iron Orchestrates Macrophage Polarization
Frontiers in Immunology, 2021 Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization.
Yaoyao Xia +9 more
doaj +1 more source
The potential role of miRNA in regulating macrophage polarization
Heliyon, 2023 Macrophage polarization is a dynamic process determining the outcome of various physiological and pathological situations through inducing pro-inflammatory responses or resolving inflammation via exerting anti-inflammatory effects.
Shaho Khayati +5 more
doaj +1 more source
Macrophage Polarization and Its Role in Liver Disease
Frontiers in Immunology, 2021 Macrophages are important immune cells in innate immunity, and have remarkable heterogeneity and polarization. Under pathological conditions, in addition to the resident macrophages, other macrophages are also recruited to the diseased tissues, and ...
Cheng Wang +7 more
doaj +1 more source
Macrophage Polarization in Atherosclerosis
Genes, 2022 The implication of the heterogeneous spectrum of pro- and anti-inflammatory macrophages (Macs) has been an important area of investigation over the last decade. The polarization of Macs alters their functional phenotype in response to their surrounding microenvironment.
Sahar Eshghjoo +4 more
openaire +2 more sources
Changes in the Small Noncoding RNAome During M1 and M2 Macrophage Polarization
Frontiers in Immunology, 2022 Macrophages belong to a special phagocytic subgroup of human leukocytes and are one of the important cells of the human immune system. Small noncoding RNAs are a group of small RNA molecules that can be transcribed without the ability to encode proteins ...
Ding Ma +7 more
doaj +1 more source
A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome. [PDF]
, 2018 The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis.
Bacova, Maria +11 more
core +12 more sources