Results 11 to 20 of about 166,541 (336)

Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

open access: yesJournal of Nanobiotechnology, 2022
Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of
Chao Liu   +11 more
doaj   +1 more source

Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury

open access: yesFrontiers in Immunology, 2021
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a condition with an imbalanced inflammatory response and delayed resolution of inflammation. Macrophage polarization plays an important role in inflammation and resolution.
Wen Zhang   +12 more
doaj   +1 more source

Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation [PDF]

open access: yes, 2013
The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during ...
Holfeld, Johannes   +9 more
core   +14 more sources

Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization

open access: yesMicrobiology Spectrum, 2023
Salmonella is one of the most important enteric pathogens worldwide, which is able to cause lethal systemic infection via survival and replication in host macrophages.
Xinyue Wang   +7 more
doaj   +1 more source

Macrophage Polarization Comes of Age [PDF]

open access: yesImmunity, 2005
Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of ...
A. Mantovani, A. Sica, M. Locati
openaire   +3 more sources

Macrophage polarization as a potential therapeutic target for atherosclerosis: a dynamic stochastic modelling study

open access: yesRoyal Society Open Science, 2022
We proposed a dynamic stochastic mathematical model to evaluate the role of macrophage polarization in plaque development. The dynamic process of macrophages from proliferation to death was simulated under different lipid microenvironments.
Mengchen Liu   +4 more
doaj   +1 more source

Metabolic Reprograming in Macrophage Polarization [PDF]

open access: yesFrontiers in Immunology, 2014
Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes ...
Silvia Galván-Peña   +1 more
openaire   +3 more sources

Macrophage polarization in tissue fibrosis

open access: yesPeerJ, 2023
Fibrosis can occur in all major organs with relentless progress, ultimately leading to organ failure and potentially death. Unfortunately, current clinical treatments cannot prevent or reverse tissue fibrosis. Thus, new and effective antifibrotic therapeutics are urgently needed.
Huidan Yang   +5 more
openaire   +3 more sources

Macrophage polarization and meta-inflammation [PDF]

open access: yesTranslational Research, 2018
Chronic overnutrition and obesity induces low-grade inflammation throughout the body. Termed "meta-inflammation," this chronic state of inflammation is mediated by macrophages located within the colon, liver, muscle, and adipose tissue. A sentinel orchestrator of immune activity and homeostasis, macrophages adopt variable states of activation as a ...
Chuan Li   +5 more
openaire   +2 more sources

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