Macrophage polarization states in atherosclerosis
Frontiers in Immunology, 2023 Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of inflammatory responses. They are involved in all stages of atherosclerosis development and progression, from plaque formation to transition into vulnerable plaques, and are ...
Jiayong Wu +10 more
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Macrophage polarization and metabolism in atherosclerosis
Cell Death & Disease, 2023 AbstractAtherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in the inner walls of vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke. The development of atherosclerosis is influenced by a variety of factors, including age, genetics, lifestyle, and ...
Hou, Pengbo +15 more
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MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation. [PDF]
PLoS ONE, 2015 Macrophages dictate both initiation and resolution of inflammation. During acute inflammation classically activated macrophages (M1) predominate, and during the resolution phase alternative macrophages (M2) are dominant. The molecular mechanisms involved
Zhuo Wang +6 more
doaj +13 more sources
Journal of Nanobiotechnology, 2022 Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of
Chao Liu +11 more
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SOCS Proteins in Macrophage Polarization and Function [PDF]
Frontiers in Immunology, 2014 Macrophages were initially described as “big eaters” due to their phagocytic nature. It is now clear that macrophages have many diverse functions not only in innate immunity and tissue homeostasis but also in metabolism, development, and regeneration.
Wilson, Heather M
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis [PDF]
Cell Death and DiseaseSepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction.
Wenjuan Peng +6 more
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Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential [PDF]
Frontiers in PharmacologyResveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties.
Panting Wang +6 more
doaj +2 more sources
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines [PDF]
Immunity, 2014 Peter J. Murray +24 more
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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization [PDF]
, 2015 Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that is only partially understood. By using an integrated high-throughput transcriptional-metabolic profiling and analysis pipeline, we characterized systemic changes ...
Abhishek Jha +12 more
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Macrophage Polarization States in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic ...
Ava J Boutilier, Sherine F. Elsawa
semanticscholar +1 more source