Results 151 to 160 of about 86,998 (259)

Genotyping of DPYD and UGT1A1 in Brazilian oncological patients: applying pharmacogenomics in an admixed population. [PDF]

Rev Assoc Med Bras (1992)
Cereser VHB, Moniz CMV, Suarez-Kurtz G, Estevez-Diz MDP.   +3 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Minor Allele Frequency Filtering Can Strongly Bias Uniqueness Estimates Within and Across Species. [PDF]

Ecol Evol
Zheng Y.
europepmc   +1 more source

Effect of Nanosilica Aggregates/Agglomerates on Functional Properties of Poly(Butylene 2,5‐Furandicarboxylate)‐Based Nanocomposites

Polymer Composites, EarlyView.
Effect of nanosilica aggregates/agglomerates on oxygen and water vapor diffusivity of PBF/SiO2 nanocomposites. ABSTRACT The nanofillers inclusions in poly(butylene 2,5‐furandicarboxylate) (PBF)/SiO2 nanocomposites were found to consist of aggregates and agglomerates of nanosilica particles.
Giovanna Molinari, Lucia Ricci, Carlo Andrea Massa, Micaela Vannini, Laura Sisti, Paola Parlanti, Mauro Gemmi, Damiano Rossi, Maurizia Seggiani, Maria Cristina Righetti   +9 more
wiley   +1 more source

Population Genetic Study of <i>vitellogenin</i> in Honey Bees (<i>Apis mellifera</i>) With European Ancestry Identifies Two Ancestral Genetic Backgrounds. [PDF]

Ecol Evol
Leipart V, Cartwright RA, Eyre-Walker A, Sandve SR, Amdam GV.   +4 more
europepmc   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

c-MAF Transcriptionally Activates Slc40a1 to Repress Ferroptosis in Sepsis-Associated Encephalopathy. [PDF]

CNS Neurosci Ther
Song W, Shen Q, Zhang H, Bu X, Gao W, Wang W.   +5 more
europepmc   +1 more source

HucMSC‐Derived Exosomes Preserve Mafb‐Dependent Tubular Epithelial Identity and Suppress Dedifferentiation in Obstructive Nephropathy

Pediatric Discovery, EarlyView.
Unilateral ureteral obstruction (UUO) and genetic deletion of Mafb lead to tubular epithelial dedifferentiation, characterized by decreased E‐cadherin and increased α‐SMA and vimentin expression. Intravenous administration of human umbilical cord mesenchymal stem cell‐derived exosomes (HucMSC‐Exos) partially restores Mafb expression in UUO kidneys ...
Zhuocheng Shi, Chenxi Jia, Meiling Chen, Yihang Yu, Deying Zhang, Guanghui Wei   +5 more
wiley   +1 more source

Technical feasibility of a long read, fourth generation sequencing platform in diagnostic profiling of clinical routine samples: a proof-of-concept study. [PDF]

Pathologica
Vitale D, Colarossi L, Russo G, Scimone C, Cozzolino D, De Luca C, Prjibelski AD, Mikheenko A, Colarossi C, Delli Muti F, Pepe F, Memeo L, Troncone G, Muscarella LA, Malapelle U.   +14 more
europepmc   +1 more source

MicroRNA‐130a‐3p Targets the Androgen‐Related Transcription Factor MAFB: Effects on Proliferation, Migration, Apoptosis, and Cell Cycle in Hypospadias

Pediatric Discovery, EarlyView.
MicroRNA‐130a‐3p targets and inhibits MAFB expression, leading to the development of hypospadimas. MicroRNA‐130a‐3p inhibits the expression of MAFB, disrupts the normal processes of cell proliferation, migration, cell apoptosis, and cycle progression, and ultimately leads to the development of hypospadias.
Jiaxin Zhou, Yixuan Wang, Zhicheng Zhang, Qiang Zhang, Zhenmin Liu, Hongsong Chen, Xingguo Luo, Chunlan Long, Lianju Shen, Xing Liu, Guanghui Wei   +10 more
wiley   +1 more source