Results 131 to 140 of about 103,106 (291)

Mitigation of quorum sensing mediated virulence factors of Pseudomonas aeruginosa: the role of Meldrum’s acid activated furan

Frontiers in Microbiology
The rapid emergence of drug resistant pathogens is a major threat which has warranted the development of alternative strategies to combat infectious diseases. In this work, we have tested the anti-virulent activity of Meldrum’s acid activated furan (MAF)
Ajmal Sadik, Jithin P. Viswaswar, Ambili Rajamoney, Anjali Rekha, Darsana M. Raj, Deepthi Prakashan, Mydhili Vasudevan, J. S. Visakh, Dhannya Renuka, Sreetha Hely, Sanu Korumadathil Shaji, Prakash R. Chandran, Geetha Kumar, Sobha Vijayan Nair, Jayalekshmi Haripriyan   +14 more
doaj   +1 more source

MAF distribution for each SNP in SP.

, 2012
Predicted values are calculated from the transcriptome MAF data and the actual MAF is from the population genotyping data.
Nancy Schult (183012), John P. Wares (183022), Christina Zakas (183010), Kenneth L. Jones (183018), Damhnait McHugh (183014)   +4 more
core   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Case report: Whole exome sequencing identified a novel mutation (p.Y301H) of MAF in a Chinese family with congenital cataracts

Frontiers in Medicine
BackgroundCongenital cataracts stand as the primary cause of childhood blindness globally, characterized by clouding of the eye’s lens at birth or shortly thereafter.
Zhao-Jing Lin, Jie-Yi Long, Juan Li, Fang-Na Wang, Wei Chu, Lei Zhu, Ya-Li Li, Liang-Liang Fan   +7 more
doaj   +1 more source

Minor allele frequency (MAF) of associated variants.

, 2012
Box plot of the minor allele frequency for all associated variants in the different scenarios. Although synthetic associations have median MAF lower than that of natural associations, the range of MAF for synthetic associations varies across the ...
Alon Keinan (153034), Diana Chang (153030)   +1 more
core   +1 more source

Heterogeneous Exhumation Mechanisms in Neoproterozoic Collisional Metamorphism: P–T Constraints From Pelotas and Punta del Este Terranes, Southern Brazil and Uruguay

Geological Journal, EarlyView.
Petrography, thermobarometry, and pseudosection modelling reveal peak metamorphic conditions of 3–7.5 kbar and 520°C–800°C in Tonian‐Cryogenian orthogneisses of the Dom Feliciano Belt. Metamorphic field gradients of 27°C/km–39°C/km and variable exhumation mechanisms support correlation of these units as remnants of a Himalayan‐type Piratini Orogeny ...
Thaiane Niederauer‐Santos, Carla Cristine Porcher, Daniel Triboli Vieira, Edinei Koester, Diego Jaldín, Karina Luengo, Luisa Caon   +6 more
wiley   +1 more source

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih, Issam Tout, Najwa Ahmad Doha, Tala Abu Arja, Idris Mohammed, Doua Abdelrhaman, Waseem Hasan, Chadi Saad, Hamdi Mbarek, Borbala Mifsud, Sahar Isa Da'as   +10 more
wiley   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Decoding the Gut‐Brain Axis: Multi‐Omics Reveals a Causal Chain Linking Human Genome, Gut Microbiota, Blood Metabolites, and Alertness in the Brain

Med Research, EarlyView.
This multi‐omics study identified genetic loci, gut microbiota, blood metabolites, and gray matter volumes of orbitofrontal cortex and cerebellum that were potentially relevant to alerting in healthy Chinese adults. Subsequent two‐step one‐sample Mendelian randomization further revealed a serial mediation pathway: Bacteroides intestinalis influences ...
Hongru Li, Chuansheng Chen, Ofir Turel, Yu Pu, Hong Chen, Tingyong Feng, Jiang Qiu, Xu Lei, Qinghua He   +8 more
wiley   +1 more source