Results 71 to 80 of about 86,998 (259)

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Bacterial Ribosomes Induce Plasticity in Mouse Adult Fibroblasts

Cells
The incorporation of bacterial ribosome has been reported to induce multipotency in somatic and cancer cells which leads to the conversion of cell lineages.
Anamika Datta, Arif Istiaq, Shigehiko Tamura, Kunimasa Ohta   +3 more
doaj   +1 more source

Study on Electrolytic Magnetic Abrasive Finishing for Finishing Stainless Steel SUS304 Plane with a Special Compound Machining Tool

Journal of Manufacturing and Materials Processing, 2018
In order to improve the finishing efficiency of traditional plane magnetic abrasive finishing (MAF), we have previously proposed an effective plane MAF process combined with an electrolytic process and developed a special compound machining tool for the ...
Xu Sun, Yanhua Zou
doaj   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

A Multi-Active and Multi-Passive Sensor Fusion Algorithm for Multi-Target Tracking in Dense Group Clutter Environments

Remote Sensing
Multi-target tracking (MTT) of multi-active and multi-passive sensor (MAMPS) systems in dense group clutter environments is facing significant challenges in measurement fusion.
Yongquan Zhang, Fan Yang, Wenbo Zhang, Aomen Shang, Zhibin Li   +4 more
doaj   +1 more source

Identification of iron status of blood donors by using low hemoglobin density and microcytic anemia factor

Asian Journal of Transfusion Science, 2018
Background: Two new parameters low hemoglobin density (LHD) and microcytic anemia factor (Maf) have been used by Beckman–Coulter LH series analyzers as an easy screening tool for the early detection of iron deficiency.
Ashutosh Singh, Rajendra Chaudhary, Hem C Pandey, Atul Sonker   +3 more
doaj   +1 more source

An IEEE Compliant Floating Point MAF [PDF]

, 2000
In this paper1. we present a new architecture for low power floating point multiply — accumulate (MAC) fusion. The proposed architecture supports IEEE and non IEEE rounding modes. The functional partitioning of the adder segment of the MAC into three distinct, clock gated data paths allows activity reduction.
R. V. K. Pillai, Dhamin Al-Khalili, Asim J. Al-Khalili   +2 more
openaire   +1 more source

Crop insurance and irrigation behavior: The conditional role of pumping costs

American Journal of Agricultural Economics, EarlyView.
Abstract Excessive water use for irrigation can accelerate the depletion of water resources, undermining agriculture's resilience to weather‐related shocks. Understanding how farmers make water use decisions is essential for developing effective water management policies.
Sungmin Cheu, Molly Sears
wiley   +1 more source