Results 71 to 80 of about 103,106 (291)

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

The mixture assessment or allocation factor: conceptual background, estimation algorithms and a case study example

Environmental Sciences Europe, 2023
Current approaches for the prospective regulatory assessment of chemicals do not account sufficiently for elevated mixture risks. The Mixture Assessment Factor (MAF, better labeled a Mixture Allocation Factor) has been suggested for mixtures of ...
Thomas Backhaus
doaj   +1 more source

Preprocessed datasets for MAF experiments

, 2018
<p><strong>Preprocessed datasets used in the experiments of the paper:</strong></p> <ul> <li>G. Papamakarios, T. Pavlakou, I.
Papamakarios, George, Papamakarios, George (5589821)   +1 more
core   +1 more source

Investigation of the oncogenic role of MAF in multiple myeloma [PDF]

, 2020
Multiple myeloma (MM) is an incurable malignancy of bone marrow plasma cells (PC), affecting over 5,600 new patients per year in the UK. Translocation of the transcription factor MAF to the IgH enhancer, t(14;16), is a myeloma-initiating event in 3-5% of
Katsarou, Alexia Despoina
core   +1 more source

On the microstructure, texture and electrochemical properties of severely deformed and artificially aged lightweight AA2050 Al–Cu–Li alloy

Materials Research Express
Lightweight 3rd generation Al–Cu–Li alloy AA2050 was severely deformed via Multi Axial Forging (MAF) at 170 °C followed by artificial aging at 150 °C.
C Jagadeesh, Shivananda Nayaka H, Prithivirajan S, Ramesh S, Gajanan Anne   +4 more
doaj   +1 more source

Performance of genotype imputation for rare variants identified in exons and flanking regions of genes. [PDF]

PLoS ONE, 2011
Genotype imputation has the potential to assess human genetic variation at a lower cost than assaying the variants using laboratory techniques. The performance of imputation for rare variants has not been comprehensively studied.
Li Li, Yun Li, Sharon R Browning, Brian L Browning, Andrew J Slater, Xiangyang Kong, Jennifer L Aponte, Vincent E Mooser, Stephanie L Chissoe, John C Whittaker, Matthew R Nelson, Margaret Gelder Ehm   +11 more
doaj   +1 more source

Crop insurance and irrigation behavior: The conditional role of pumping costs

American Journal of Agricultural Economics, EarlyView.
Abstract Excessive water use for irrigation can accelerate the depletion of water resources, undermining agriculture's resilience to weather‐related shocks. Understanding how farmers make water use decisions is essential for developing effective water management policies.
Sungmin Cheu, Molly Sears
wiley   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Vitamin D Binding Protein-Macrophage Activating Factor (DBP-maf) Inhibits Angiogenesis and Tumor Growth in Mice

Neoplasia: An International Journal for Oncology Research, 2003
We have isolated a selectively deglycosylated form of vitamin D binding protein (DBP-maf) generated from systemically available DBP by a human pancreatic cancer cell line.
Oliver Kisker, Shinya Onizuka, Christian M. Becker, Michael Fannon, Evelyn Flynn, Robert D'Amato, Bruce Zetter, Judah Folkman, Rahul Ray, Narasimha Swamy, Steven Pirie-Shepherd   +10 more
doaj   +1 more source

Expanding the Phenotypic Spectrum of TXNDC15‐Related Ciliopathies to Include Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic loss‐of‐function variants in TXNDC15 are a known cause of the perinatally lethal ciliopathy Meckel syndrome (MKS). TXNDC15 encodes an endoplasmic reticulum (ER)‐resident thioredoxin‐domain protein required for ciliary transition zone integrity.
Zachary T. Sentell, Robert Geraghty, Juliana E. Arcila‐Galvis, Praveen Dhondurao‐Sudhindar, Sergio Foullerat Cañada, Fulvio D'Abrusco, Bosanka Jocic‐Jakubi, Miguel Barroso‐Gil, Valentina Serpieri, Thomas M. Kitzler, Kate E. Chandler, Eleanor G. Seaby, Gabrielle Wheway, Jennifer C. Dempsey, Dan Doherty, Enza M. Valente, John A. Sayer   +16 more
wiley   +1 more source