Results 231 to 240 of about 14,436 (263)

MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection.

Science immunology
Mucosal-associated invariant T (MAIT) cells are known for their rapid effector functions and antibacterial immune protection. Here, we define the plasticity of interferon-γ (IFN-γ)-producing MAIT1 and interleukin-17A (IL-17A)-producing MAIT17 cell ...
Huimeng Wang, Michael N. T. Souter, Marcela de Lima Moreira, Shihan Li, Yuchen Zhou, Adam G. Nelson, Jinhan Yu, Lucy J Meehan, Bronwyn S. Meehan, S. Eckle, H. J. Lee, Jan Schröder, A. Haque, Jeffrey Y. W. Mak, David P. Fairlie, James McCluskey, Zhongfang Wang, Zhenjun Chen, A. Corbett   +18 more
semanticscholar   +1 more source

MAIT cells and MR1-antigen recognition

Current Opinion in Immunology, 2017
Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector ...
Andrew N, Keller, Alexandra J, Corbett, Jacinta M, Wubben, James, McCluskey, Jamie, Rossjohn   +4 more
openaire   +2 more sources

Deficiency in Peripheral MAIT Cells But Not in Intrahepatic MAIT Cells in Humans with CHBV Infection

SSRN Electronic Journal, 2019
Background: Chronic hepatitis B virus (CHBV) infection is a major cause of liver diseases. Mucosal-associated invariant T (MAIT) cells are important for antiviral immunity in the liver, but the distinction between intrasinusoidal MAIT cells and peripheral MAIT cells in patients with CHBV infection remains unclear.
Wenyong Huang, Wenjing He, Xiaomin Shi, Qianyu Ye, Xiaoshun He, Lang Dou, Yifang Gao   +6 more
openaire   +1 more source

MAIT cell-MR1 reactivity is highly conserved across multiple divergent species

Journal of Biological Chemistry
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize small molecule metabolites presented by major histocompatibility complex class I related protein 1 (MR1), via an αβ T cell receptor (TCR). MAIT TCRs feature
Matthew D. Edmans, Timothy K. Connelley, S. Morgan, Troi J Pediongco, S. Jayaraman, J. Juno, Bronwyn S. Meehan, Phoebe M. Dewar, E. Maze, Eduard Otto Roos, Basudev Paudyal, Jeffrey Y. W. Mak, Ligong Liu, D. Fairlie, Huimeng Wang, A. Corbett, James McCluskey, L. Benedictus, E. Tchilian, P. Klenerman, S. Eckle   +20 more
semanticscholar   +1 more source

Signals that control MAIT cell function in healthy and inflamed human tissues

Immunological Reviews
Mucosal‐associated invariant T (MAIT) cells have a semi‐invariant T‐cell receptor that allows recognition of antigen in the context of the MHC class I‐related (MR1) protein. Metabolic intermediates of the riboflavin synthesis pathway have been identified
Andrew J. Konecny, Yin-Fei Huang, Manu Setty, Martin Prlic   +3 more
semanticscholar   +1 more source

MAIT Cell Activation by Fungal Pathogens

2019
MAIT cells can recognize and respond to several pathogens in a distinct manner. However, many studies are focused on activation by bacteria and by viruses, while reports about molds and MAIT cells are rare. Here, we describe a method to investigate MAIT cell interaction with filamentous fungi from Aspergillus and Mucorales species.
Susanne, Jahreis, Sarah, Boettcher, Marie, von Lilienfeld-Toal   +2 more
openaire   +2 more sources

Keratinocytes stimulate MAIT cells to produce granzyme B via MR1 and cytokines in oral lichen planus.

Oral Diseases
OBJECTIVE Oral lichen planus (OLP) is a chronic inflammatory disease characterized by a dense T-cell infiltration and the degeneration of basal keratinocytes.
Qin Jiang, Fang Wang, Gang Zhou
semanticscholar   +1 more source

Enrichment of liver MAIT cells in a mouse model of Alzheimer’s disease

Journal of Neuroimmunology
Emerging evidence has supported a role for the immune system and liver in Alzheimer’s disease (AD). However, our understanding of how hepatic immune cells are altered in AD is limited.
Season K. Wyatt-Johnson, Holly N. Kersey, R. Brutkiewicz   +2 more
semanticscholar   +1 more source

Characterization of MAIT TCR repertoire of gastrointestinal tract and peripheral blood MAIT cells

2023
Mucosal-associated invariant T (MAIT) cells are an innate-like T cell that rapidly respond to infection. MAIT cells are αβ T cells that possess a Vα7.2 (TRAV1-2) TCR with mostly pairing to TRAJ33, TRAJ20 or TRAJ12 and predominantly TRBV20-1, TRBV6-1 and TRBV6-4.
openaire   +1 more source

Reprogramming of MAIT Cells to Pluripotency and Redifferentiation

2019
Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) consists in dedifferentiation of the cells into the pluripotent state, i.e., stem cells. Since T cells play a pivotal role in our immune system, T cell reprogramming into iPSCs and subsequent redifferentiation of iPSCs toward the original cells hold a great promise for ...
openaire   +2 more sources