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Control of MAIT cell functions by cytokines in health and disease
Frontiers in ImmunologyMucosal-associated invariant T (MAIT) cells are innate-like T cells that express a semi-invariant T cell receptor (TCR). These cells predominantly reside in tissues, such as the liver, lung, skin and the gastrointestinal tract.
Laetitia Camard +2 more
semanticscholar +1 more source
CD2 and its ligands are involved in development and activation of MAIT cells.
Journal of Experimental MedicineMAIT cells are innate-like T cells known for their semi-invariant TCR that recognizes vitamin B metabolites presented by MR1. While the involvement of TCR and cytokines in development and activation of MAIT cells is well documented, the contribution of ...
Kaiwen Zhu +7 more
semanticscholar +1 more source
Human MAIT cells undergo clonal selection and expansion during thymic maturation and aging
Experimental and Molecular MedicineMucosal-associated invariant T (MAIT) cells harbor conserved T cell receptors (TCRs) recognizing riboflavin metabolites, yet exhibit substantial diversity similar to conventional memory T cells.
Myeong-seok Lee +7 more
semanticscholar +1 more source
Nature Reviews Immunology, 2019
Commensal bacteria at mucosal surfaces can remotely control the thymic maturation of mucosal-associated invariant T cells through the production of microbial factors that enter the circulation and are taken up by thymic cells.
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Commensal bacteria at mucosal surfaces can remotely control the thymic maturation of mucosal-associated invariant T cells through the production of microbial factors that enter the circulation and are taken up by thymic cells.
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Neuro-Oncology Advances
Background Glioblastoma (GBM) is the most aggressive primary brain cancer in adults and remains incurable. Mucosal-associated invariant T (MAIT) cells are unconventional T cells with a semi-invariant T cell receptor and have been shown to regulate immune
Seketoulie Keretsu +20 more
semanticscholar +1 more source
Background Glioblastoma (GBM) is the most aggressive primary brain cancer in adults and remains incurable. Mucosal-associated invariant T (MAIT) cells are unconventional T cells with a semi-invariant T cell receptor and have been shown to regulate immune
Seketoulie Keretsu +20 more
semanticscholar +1 more source
Journal for ImmunoTherapy of Cancer
Background Mucosa-associated invariant T (MAIT) cells represent a unique population of innate-like T lymphocytes capable of detecting non-peptide antigens in the context of monomorphic antigen-presenting molecules.
Inbar A Habaz +16 more
semanticscholar +1 more source
Background Mucosa-associated invariant T (MAIT) cells represent a unique population of innate-like T lymphocytes capable of detecting non-peptide antigens in the context of monomorphic antigen-presenting molecules.
Inbar A Habaz +16 more
semanticscholar +1 more source
Journal of Autoimmunity
BACKGROUND & AIMS Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset that plays a significant role in the immunopathology of primary biliary cholangitis (PBC). However, our understanding of the subpopulations involved in hepatic
Qiyun Xia +10 more
semanticscholar +1 more source
BACKGROUND & AIMS Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset that plays a significant role in the immunopathology of primary biliary cholangitis (PBC). However, our understanding of the subpopulations involved in hepatic
Qiyun Xia +10 more
semanticscholar +1 more source
arXiv.org
While machine learning offers diverse techniques suitable for exploring various medical research questions, a cohesive synergistic framework can facilitate the integration and understanding of new approaches within unified model development and ...
R. Z. Marandi +4 more
semanticscholar +1 more source
While machine learning offers diverse techniques suitable for exploring various medical research questions, a cohesive synergistic framework can facilitate the integration and understanding of new approaches within unified model development and ...
R. Z. Marandi +4 more
semanticscholar +1 more source
Defenders or Defectors: MAIT Cells in Autoimmune Diseases
Current Opinion in ImmunologyMucosal associated invariant T (MAIT) cells recognize microbial riboflavin metabolites presented by MR1, an MHC class I-like protein. Activated MAIT cells produce cytokines such as IFNγ, TNF and IL-17, they traffic to sites of infection and participate ...
Mitchell Kronenberg, Thomas Riffelmacher
semanticscholar +1 more source
MAITs, MR1 and vitamin B metabolites
Current Opinion in Immunology, 2014αβT-cell mediated immunity is traditionally characterised by recognition of peptides or lipids presented by the major histocompatibility complex (MHC) or the CD1 family respectively. Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of ...
Richard W, Birkinshaw +4 more
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