Results 211 to 220 of about 14,436 (263)

Sulfated bile acid is a host-derived ligand for MAIT cells

Science immunology
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize bacterial riboflavin–based metabolites as activating antigens. Although MAIT cells are found in tissues, it is unknown whether any host tissue–derived antigens exist. Here,
E. Ito, S. Inuki, Yoshihiro Izumi, Masatomo Takahashi, Yuki Dambayashi, Lisa Ciacchi, W. Awad, Ami Takeyama, Kensuke Shibata, Shotaro Mori, Jeffrey Y. W. Mak, D. Fairlie, T. Bamba, E. Ishikawa, Masamichi Nagae, Jamie Rossjohn, Sho Yamasaki   +16 more
semanticscholar   +1 more source

MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles

Science immunology
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules.
Tobias Kammann, Curtis Cai, Takuya Sekine, Elli Mouchtaridi, Caroline Boulouis, Vera Nilsén, O. R. Ballesteros, Thomas R. Müller, Yu Gao, Elisa J. M. Raineri, Akhirunnesa Mily, Sarah Adamo, Christian Constantz, Julia Niessl, Whitney Weigel, Efthymia Kokkinou, Christopher T Stamper, Anne Marchalot, John Bassett, Sabrina Ferreira, Inga Rødahl, Nicole Wild, D. Brownlie, C. Tibbitt, Jeffrey Y. W. Mak, D. Fairlie, E. Leeansyah, J. Michaelsson, N. Marquardt, J. Mjösberg, C. Jorns, M. Buggert, J. Sandberg   +32 more
semanticscholar   +1 more source

MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis

Mucosal Immunology
IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucosal-Associated-Invariant-T-cells (MAIT), a subset of innate-like T cells with features of both Th1 and ...
Liyen Loh, D. Orlicky, Andrea Spengler, Joanne Domenico, J. Klarquist, Cassandra Levens, Sofia Celli, J. Kofonow, Charles E. Robertson, Olivier Lantz, F. Legoux, Daniel N. Frank, Jennifer L. Matsuda, Paul J. Norman, Kristine A. Kuhn, Joseph C. Onyiah, Laurent Gapin   +16 more
semanticscholar   +1 more source

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells exhibit an intrinsic ability to recognize and respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells specifically detects the non-polymorphic antigen-presenting molecule,
Melissa D. Chengalroyen, N. Oketade, A. Worley, Megan Lucas, Luisa Maria Nieto Ramirez, Mabule L. Raphela, Gwendolyn M. Swarbrick, Paul S. Soma, Mandisa Zuma, D. Warner, D. Lewinsohn, Carolina Mehaffy, Erin J. Adams, William H. Hildebrand, K. Dobos, Valerie Mizrahi, David M. Lewinsohn   +16 more
semanticscholar   +1 more source

MAITS

2007
In this chapter, we propose a multi-agent-based information technology (IT) security approach (MAITS) as a holistic solution to the increasing needs of securing computer systems. Each specialist task for security requirements is modeled as a specialist agent.
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MAIT cell development in mice and humans

Molecular Immunology, 2021
MAIT cells arise in the thymus following rearrangement of a T cell receptor (TCR) reactive against microbial vitamin B2-derived metabolites presented by the MHC-Ib molecule, MR1. Mechanisms that are conserved in mammals ensure the frequent production of MR1-restricted TCRs and the intra-thymic differentiation of MR1-restricted thymocytes into effector ...
Marion, Salou, François, Legoux, Olivier, Lantz   +2 more
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Mucosal-Associated Invariant T (MAIT) Cell–Mediated Immune Mechanisms of Peritoneal Dialysis–Induced Peritoneal Fibrosis and Therapeutic Targeting

Journal of the American Society of Nephrology
Visual Abstract Key Points Peritoneal mucosal-associated invariant T (MAIT) cells were characterized by single-cell RNA sequencing, histological imaging, and flow cytometry.
Yuxiang Sun, Qiang Huang, Juan Sun, Hu Zhou, Dandan Guo, Long Peng, Hongchun Lin, Canming Li, Hongli Shang, Tongtong Wang, Yanxu Chen, Yong Huang, Cheng Hu, Zhaoyong Hu, Yan Lu, Hui Peng   +15 more
semanticscholar   +1 more source

Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation.

Science
Mucosal associated invariant T (MAIT) cells mediate tissue homeostasis and antimicrobial immunity. However, the cells that express MHC class I-related protein 1 (MR1) and present microbial vitamin B-derived antigens (VitBAg) to MAIT cells remain unknown.
Jieru Deng, Yuting Yan, Xiaoyue Zhang, Calum J. Walsh, Emmanuel Montassier, Debajyoti Sinha, Huimeng Wang, A. Mousavizadeh, Mitra Ashayeripanah, Jeffrey Y. W. Mak, H. Koay, Tobias Poch, Yannick O. Alexandre, Scott N. Mueller, Ajithkumar Vasanthakumar, Tim P Stinear, Vanta J Jameson, Alexis Perez-Gonzalez, Jenny Kingham, T. G. Phan, Nikita Potemkin, Lachlan Dryburgh, Jan Schroeder, David P. Fairlie, Laura K. Mackay, Zhenjun Chen, Laura Cook, Abderrahman Hachani, A. Corbett, A. Roquilly, J. Villadangos, Hamish E. G. McWilliam   +31 more
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MAIT and iNKT cells in tissue homeostasis and repair.

Immunobiology
Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) are innate-like T cells, which develop in the thymus through an original developmental program leading to the acquisition of effector memory and tissue targeting phenotypes ...
R. A. Paiva, M. Salou
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MAIT cells and pathogen defense

Cellular and Molecular Life Sciences, 2014
Mucosa-associated invariant T (MAIT) cells are a unique population of innate T cells that are abundant in humans. These cells possess an evolutionarily conserved invariant T cell receptor α chain restricted by the nonpolymorphic class Ib major histocompatibility (MHC) molecule, MHC class I-related protein (MR1). The recent discovery that MAIT cells are
openaire   +2 more sources