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MAIT Cell Activation by Fungal Pathogens
2019MAIT cells can recognize and respond to several pathogens in a distinct manner. However, many studies are focused on activation by bacteria and by viruses, while reports about molds and MAIT cells are rare. Here, we describe a method to investigate MAIT cell interaction with filamentous fungi from Aspergillus and Mucorales species.
Susanne, Jahreis +2 more
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MAIT cells and MR1-antigen recognition
Current Opinion in Immunology, 2017Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector ...
Andrew N, Keller +4 more
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Charting MAIT cell development
Science, 2019T Cells Mucosal-associated invariant T (MAIT) cells are a distinct subset of T cells that recognize vitamin B metabolites presented by major histocompatibility complex class I–related protein (MR1). Koay et al. used bulk and single-cell RNA sequencing and flow cytometric analysis to characterize the development of murine and human MAIT cells.
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MAIT Cells in Health and Disease
2019Mucosal-associated invariant T (MAIT) cells are a newly described subset of T cells that are found in the blood and are enriched in many tissues, particularly in the liver. MAIT cells express a semi-invariant T cell receptor restricted by the MHC class I-related (MR1) molecule. MAIT cells are activated in a MR1-dependent manner in response to microbial-
Isabelle, Magalhaes +2 more
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Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin
Cell, 2023Benjamin Ruf +2 more
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