Results 201 to 210 of about 14,436 (263)

Systemic and airway T cell dynamics with influenza-specific immune recovery by cystic fibrosis elexacaftor/tezacaftor/ivacaftor therapy. [PDF]

Respir Res
Mouchtaridi E, Kowalik A, Raineri EJM, Humbert M, Jägerstedt J, Bojarlind M, Nilsson K, Flodström-Tullberg M, Pincikova T, Sandberg JK.   +9 more
europepmc   +1 more source

MAIT cells and viruses [PDF]

Immunology and Cell Biology, 2018
AbstractMucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially derived metabolites. Functionally, they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1.
James E Ussher, Christian B Willberg, Paul Klenerman   +2 more
exaly   +5 more sources

Development and Functions of MAIT Cells.

Annual Review of Immunology
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that recognize microbial metabolites. They are abundant in humans and conserved during mammalian evolution, which suggests that they have important nonredundant functions ...
M. Salou, R. A. Paiva, Olivier Lantz
semanticscholar   +3 more sources

Human liver‐derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR‐independent activation

European Journal of Immunology, 2021
Mucosal associated invariant T (MAIT) cells are anti-microbial innate-like T cells that are abundant in blood and liver. MAIT cells express a semi-invariant T-cell receptor (TCR) that recognizes a pyrimidine ligand, derived from microbial riboflavin ...
Rajesh Lamichhane, Thomas W R Harrop, Peter K Dearden   +2 more
exaly   +2 more sources

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MAIT Cells in Health and Disease

Annual Review of Immunology, 2020
Mucosal-associated invariant T (MAIT) cells have been attracting increasing attention over the last few years as a potent unconventional T cell subset. Three factors largely account for this emerging interest. Firstly, these cells are abundant in humans, both in circulation and especially in some tissues such as the liver.
Nicholas M Provine, Paul Klenerman
exaly   +3 more sources

Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD.

Journal of Hepatology
BACKGROUND & AIMS Mucosal-associated invariant T (MAIT) cells constitute a highly abundant innate-like T cell population in the human liver that is critical for immune surveillance of hepatic cancers but often dysfunctional in human hepatocellular ...
Sebastian Deschler, Junika Pohl-Topcu, Lukas Ramsauer, Philippa Meiser, S. Erlacher, Robin P. Schenk, H. C. Maurer, Peng Shen, J. Kager, Joseph Zink, K. Pistrenko, E. Monte, Julius Weber, Lena Wasmaier, M. Laschinger, Norbert Hüser, F. Geisler, Douglas Thorburn, Hanno Niess, Gabriela M. Wiedemann, H. Zischka, Mathias F Heikenwälder, Karin Kleigrewe, C. Mogler, Jan P. Böttcher, Percy A. Knolle, Roland M. Schmid, K. Böttcher   +27 more
semanticscholar   +1 more source

Role of MAIT cells in metabolic diseases

Molecular Immunology, 2021
MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and maintaining chronic inflammation. In
Amine, Toubal, Agnès, Lehuen
openaire   +2 more sources

The biology and functional importance of MAIT cells

Nature Immunology, 2019
In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative ...
D. Godfrey, H. Koay, J. McCluskey, N. Gherardin   +3 more
semanticscholar   +3 more sources

MAIT cells in infectious diseases

Current Opinion in Immunology, 2017
In humans, MAIT cells represent the most abundant T cell subset reacting against bacteria. Their frequency in the blood is decreased in a large variety of infectious diseases of either bacterial or viral origin. MAIT cells accumulate at the site of bacterial infection and are protective in experimental infection models.
Marion, Salou, Katarzyna, Franciszkiewicz, Olivier, Lantz   +2 more
openaire   +2 more sources

Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18

Nature Communications
Mast cells (MC) serve as pivotal sentinels in the regulation of immune responses and inflammation, yet their function in lung adenocarcinoma (LUAD) remains largely neglected.
F. Fan, Jun Wang, Kun Liu, ShiYue Zhang, Jian Gao, Xiongfei Li, Jiaqiang Ma, Yue Zhao, Teng Li, Han Su, Xinfeng Yang, Han Han, Qingyuan Huang, Yiliang Zhang, Yunjian Pan, Ting Ye, Hong Hu, Yihua Sun, Fei Li, Zhiwei Cao, Yang Zhang, Xiaoming Zhang, Haiquan Chen   +22 more
semanticscholar   +1 more source