Use of Mass Spectrometry to Determine the Diversity of Toxins Produced by Gambierdiscus and Fukuyoa Species from Balearic Islands and Crete (Mediterranean Sea) and the Canary Islands (Northeast Atlantic) [PDF]
Toxins, 2020 Over the last decade, knowledge has significantly increased on the taxonomic identity and distribution of dinoflagellates of the genera Gambierdiscus and Fukuyoa. Additionally, a number of hitherto unknown bioactive metabolites have been described, while
Pablo Estevez +8 more
doaj +7 more sources
Structural Characterization of Maitotoxins Produced by Toxic Gambierdiscus Species [PDF]
Marine Drugs, 2022 Identifying compounds responsible for the observed toxicity of the Gambierdiscus species is a critical step to ascertaining whether they contribute to ciguatera poisoning.
J. Sam Murray +9 more
doaj +5 more sources
Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus [PDF]
Marine Drugs, 2017 Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning.
Francesco Pisapia +12 more
doaj +9 more sources
Bimodal Cell Size and Fusing Cells Observed in a Clonal Culture of the Ciguatoxin-Producing Benthic Dinoflagellate Gambierdiscus (WC1/1) [PDF]
Toxins, 2022 Cells in a clonal culture of the WC1/1 strain of Gambierdiscus that produced ciguatoxin and maitotoxin-3 were observed to spontaneously fuse during the light phase of culture growth.
Michael J. Holmes, Richard J. Lewis
doaj +2 more sources
Toxicity Screening of a Gambierdiscus australes Strain from the Western Mediterranean Sea and Identification of a Novel Maitotoxin Analogue [PDF]
Marine Drugs, 2021 Dinoflagellate species of the genera Gambierdiscus and Fukuyoa are known to produce ciguatera poisoning-associated toxic compounds, such as ciguatoxins, or other toxins, such as maitotoxins.
Pablo Estevez +8 more
doaj +2 more sources
Gambierdiscus and Its Associated Toxins: A Minireview [PDF]
Toxins, 2022 Gambierdiscus is a dinoflagellate genus widely distributed throughout tropical and subtropical regions. Some members of this genus can produce a group of potent polycyclic polyether neurotoxins responsible for ciguatera fish poisoning (CFP), one of the ...
Da-Zhi Wang, Ye-Hong Xin, Ming-Hua Wang
doaj +2 more sources
Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus [PDF]
Toxins, 2019 Gambierdiscus species are the producers of the marine toxins ciguatoxins and maitotoxins which cause worldwide human intoxications recognized as Ciguatera Fish Poisoning. A deep chemical investigation of a cultured strain of G.
Andrea Boente-Juncal +7 more
doaj +2 more sources
Targeted Metabolite Fingerprints of Thirteen Gambierdiscus, Five Coolia and Two Fukuyoa Species [PDF]
Marine DrugsThe genus Gambierdiscus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen Gambierdiscus, five Coolia and two ...
J. Sam Murray +12 more
doaj +2 more sources
Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches. [PDF]
Mar Drugs, 2021 Producción CientíficaIntracellular Ca2+ plays a pivotal role in the control of a large series of cell functions in all types of cells, from neurotransmitter release and muscle contraction to gene expression, cell proliferation and cell death.
González-Andrés P +5 more
europepmc +3 more sources
Maitotoxin Is a Potential Selective Activator of the Endogenous Transient Receptor Potential Canonical Type 1 Channel in Xenopus laevis Oocytes [PDF]
Marine Drugs, 2017 Maitotoxin (MTX) is the most potent marine toxin known to date. It is responsible for a particular human intoxication syndrome called ciguatera fish poisoning (CFP). Several reports indicate that MTX is an activator of non-selective cation channels (NSCC)
Pedro L. Flores +5 more
doaj +2 more sources