Results 141 to 150 of about 811 (177)
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Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin
Journal of the American Chemical Society, 2008As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge. After its originally proposed structure ( 1) had been questioned on the basis of biosynthetic considerations, we provided computational and experimental support for structure 1.
K C, Nicolaou +9 more
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Modulation of the maitotoxin response by intracellular and extracellular cations
Toxicon, 2002The aim of the present study was to characterize the role played by intracellular and extracellular calcium and sodium on the maitotoxin (MTX) response in Chinese hamster ovary (CHO) cells. The results presented here indicated that: (1) MTX activates calcium and sodium influx in a concentration-dependent manner; (2) extracellular calcium is required ...
V, Morales-Tlalpan, L, Vaca
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2000
Abstract Ciguatoxin, scaritoxin, and maitotoxin (MTX) are the marine compounds held responsible for ciguatera poisoning, although the role of MTX is disputed (8). Like ciguatoxin, MTX is produced by the marine dinoflagellate Gambier discus toxicus, and accumulates in the marine food chain in fish in tropical coral reefs.
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Abstract Ciguatoxin, scaritoxin, and maitotoxin (MTX) are the marine compounds held responsible for ciguatera poisoning, although the role of MTX is disputed (8). Like ciguatoxin, MTX is produced by the marine dinoflagellate Gambier discus toxicus, and accumulates in the marine food chain in fish in tropical coral reefs.
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ChemInform Abstract: Maitotoxin — An Inspiration for Synthesis
ChemInform, 2011AbstractReview: 220 refs.
K. C. Nicolaou, Robert J. Aversa
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Maitotoxin, a cationic channel activator.
Neurobiology (Budapest, Hungary), 1998Maitotoxin (MTX), a water soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus is one of the entities responsible for Ciguatera, a form of seafood poisoning. This toxin is a potent activator of changes in the intracellular Ca2+ concentrations of cells from a wide variety of organisms.
L I, Escobar +3 more
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Comparison of maitotoxin with thromboxane A2 in rabbit platelet activation
Toxicon, 1999Maitotoxin (MTX), a Ca2+ channel-activating marine toxin, caused shape change followed by aggregation in rabbit platelets, like U46619, a thromboxane A2 analogue. Although both drugs failed to cause aggregation in the absence of external Ca2+, U46619, but not maitotoxin, elicited shape change in the absence of external Ca2+.
N, Nakahata +5 more
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Antibodies to maitotoxin elicited by immunization with toxin-fragment conjugates
Toxicon, 1996Maitotoxin is a water-soluble polyether toxin produced by the benthic dinoflagellate, Gambierdiscus toxicus. Toxin fragments generated by periodate oxidation were conjugated to keyhole limpet hemocyanin, and the resulting immunogens were used to elicit maitotoxin-specific antibodies in mice.
G S, Bignami, D F, Waller, T, Yasumoto
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ChemInform Abstract: Complete Structure of Maitotoxin
ChemInform, 1998AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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On the Structure of Maitotoxin
Angewandte Chemie International Edition, 2007K C, Nicolaou, Michael O, Frederick
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