Results 141 to 150 of about 1,584 (185)

ChemInform Abstract: Structure of Maitotoxin

ChemInform, 1993
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. MURATA, H. NAOKI, T. IWASHITA, S. MATSUNAGA, M. SASAKI, A. YOKOYAMA, T. YASUMOTO   +6 more
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Maitotoxin-induced membrane current in neuroblastoma cells

Brain Research, 1987
Maitotoxin (MTX) is a potent marine toxin isolated from the toxic dinoflagellate, Gambierdiscus toxicus. We have examined the possibility of MTX activating calcium channels using cultured neuroblastoma cells (N1E-115). MTX (10 ng/ml) produced a depolarization of the membrane, which was prevented by the removal of Ca2+ from the external medium.
M, Yoshii, A, Tsunoo, Y, Kuroda, C H, Wu, T, Narahashi   +4 more
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Modulation of a calcium-activated chloride current by Maitotoxin

Toxicon, 1999
The effect of Maitotoxin (MTX) on the calcium-activated chloride current (ICl-Ca) from Xenopus oocytes was studied, applying the two-electrode voltage clamp technique. MTX increased the current amplitude at all the voltages explored and reduced the time to reach the maximum current level (time to peak). At low toxin concentrations (15 pM), both effects
M, Martínez, C, Salvador, J M, Farias, L, Vaca, L I, Escobar   +4 more
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Complete structure of maitotoxin

Pure and Applied Chemistry, 1998
Abstract
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Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin

Journal of the American Chemical Society, 2008
As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge. After its originally proposed structure ( 1) had been questioned on the basis of biosynthetic considerations, we provided computational and experimental support for structure 1.
K C, Nicolaou, Michael O, Frederick, Antonio C B, Burtoloso, Ross M, Denton, Fatima, Rivas, Kevin P, Cole, Robert J, Aversa, Romelo, Gibe, Taiki, Umezawa, Takahiro, Suzuki   +9 more
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Complete Relative Stereochemistry of Maitotoxin

Journal of the American Chemical Society, 1996
By addressing the relative stereochemistry of the four acyclic portions via organic synthesis, the complete relative stereochemistry of maitotoxin (MTX) has been established as 1B. The relative stereochemistry of the C.1−C.15 portion was elucidated via a two-phase approach:  (1) the synthesis of the eight diastereomers possible for model C ...
Wanjun Zheng, John A. DeMattei, Jiang-Ping Wu, James J.-W. Duan, Laura R. Cook, Hitoshi Oinuma, Yoshito Kishi   +6 more
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Mechanisms underlying the hemolytic and ichthyotoxic activities of maitotoxin

Natural Toxins, 1999
Maitotoxin (MTX), a putative Ca(2+) channel activator produced by the dinoflagellate Gambierdiscus toxicus showed extremely potent hemolytic and ichthyotoxic activities. Hemolysis of 1% mouse blood cell suspension in saline occurred at 15 nM of MTX.
T, Igarashi, S, Aritake, T, Yasumoto
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Modulation of the maitotoxin response by intracellular and extracellular cations

Toxicon, 2002
The aim of the present study was to characterize the role played by intracellular and extracellular calcium and sodium on the maitotoxin (MTX) response in Chinese hamster ovary (CHO) cells. The results presented here indicated that: (1) MTX activates calcium and sodium influx in a concentration-dependent manner; (2) extracellular calcium is required ...
V, Morales-Tlalpan, L, Vaca
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Maitotoxin

2000
Abstract Ciguatoxin, scaritoxin, and maitotoxin (MTX) are the marine compounds held responsible for ciguatera poisoning, although the role of MTX is disputed (8). Like ciguatoxin, MTX is produced by the marine dinoflagellate Gambier discus toxicus, and accumulates in the marine food chain in fish in tropical coral reefs.
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ChemInform Abstract: Maitotoxin — An Inspiration for Synthesis

ChemInform, 2011
AbstractReview: 220 refs.
K. C. Nicolaou, Robert J. Aversa
openaire   +1 more source