Results 31 to 40 of about 1,556 (163)

Ladder-Shaped Ion Channel Ligands: Current State of Knowledge

Marine Drugs, 2017
Ciguatoxins (CTX) and brevetoxins (BTX) are polycyclic ethereal compounds biosynthesized by the worldwide distributed planktonic and epibenthic dinoflagellates of Gambierdiscus and Karenia genera, correspondingly.
Yuri B. Shmukler, Denis A. Nikishin
doaj   +1 more source

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]

, 2009
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1 beta (IL-1 beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns
Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P. Lee, Hal M. Hoffman, Vishva M. Dixit, Aguilar-Bryan, Ashcroft, Boyden, Cassel, Clement, Dostert, Duncan, Halle, Hamon, Hoffman, Hornung, Kanneganti, Kanneganti, Laliberte, Lamkanfi, Lamkanfi, Locovei, Ma, Mariathasan, Mariathasan, Martinon, Marty, Meyer, Miki, Miki, Pelegrin, Pelegrin, Perregaux, Riddle, Rosengren, Schott, Solle, Stoller, Sutterwala, Yvan-Charvet   +43 more
core   +2 more sources

Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay.

PLoS ONE, 2016
BackgroundCiguatera is a circumtropical disease produced by polyether sodium channel toxins (ciguatoxins) that enter the marine food chain and accumulate in otherwise edible fish.
Richard J Lewis, Marco Inserra, Irina Vetter, William C Holland, D Ransom Hardison, Patricia A Tester, R Wayne Litaker   +6 more
doaj   +1 more source

Epoxide-Opening Cascades in the Synthesis of Polycyclic Polyether Natural Products [PDF]

, 2009
The structural features of polycyclic polyether natural products can, in some cases, be traced to their biosynthetic origin. However in case that are less well understood, only biosynthetic pathways that feature dramatic, yet speculative, epoxide-opening
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Maitotoxin, a potent, general activator of phosphoinositide breakdown [PDF]

FEBS Letters, 1989
Maitotoxin (MTX), a potent marine toxin, elicits a calcium‐dependent activation of cells that can be inhibited by calcium channel blockers like nifedipine. MTX also stimulates phosphoinositide breakdown in smooth muscle cells, NCB‐20 cells and PC12 cells through a nifedipine‐insensitive mechanism.
Gusovsky, Fabian, Yasumoto, Takeshi, Daly, John W.   +2 more
openaire   +2 more sources

Release of full-length PrPC from cultured neurons following neurotoxic challenges

Frontiers in Neurology, 2012
The susceptibility of the normal cellular prion protein isoform, PrPC, to proteolytic digestion has been well documented. In addition, a link between PrPC and the cytosolic protease, calpain, has been reported although the specifics of the interaction ...
Kevin K W Wang, Kevin K W Wang, Susie eZoltewicz, Allen eChiu, Zhiqun eZhang, Zhiqun eZhang, Richard eRubenstein   +6 more
doaj   +1 more source

Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry [PDF]

, 2011
Eighteen (2RS,6RS)-2-(4-methoxyphenyl)-6-(substituted ethyl)dihydro- 2Hpyran-4(3H)ones were synthesized via a DDQ-mediated oxidative carbon-hydrogen bond activation reaction.
Farid, R, Floreancig, PE, LaPorte, MG, Liu, L, Wipf, P, Zaware, N   +5 more
core   +3 more sources

The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning

Marine Drugs, 2017
Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at
Lesley L. Rhodes, Kirsty F. Smith, Sam Murray, D. Tim Harwood, Tom Trnski, Rex Munday   +5 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

The development of endo-selective epoxide-opening cascades in water [PDF]

, 2009
This tutorial review traces the development of endo-regioselective epoxide-opening reactions in water. Templated, water-promoted epoxide-opening cyclization reactions can offer rapid access to subunits of the ladder polyethers, a fascinating and complex ...
Byers, Jeffery A., Jamison, Timothy F., Morten, Christopher J., Van Dyke, Aaron R., Vilotijevic, Ivan   +4 more
core   +1 more source