Results 41 to 50 of about 1,556 (163)
Synthesis of the C′D′E′F′ Domain of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 A devised biomimetic strategy toward the C'D'E'F' domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all attempts to induce the desired cascade to form the targeted compound through a zip-type reaction under neutral or acidic conditions failed, prompting adoption of a linear stepwise approach to 6 ...
K C, Nicolaou +3 more
openaire +2 more sources
Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex [PDF]
, 1922 The purinergic receptor P2X7 is part of a complex signaling mechanism participating in a variety of physiological and pathological processes. Depending on the activation scheme, P2X7 receptors in vivo are non-selective cation channels or form large pores
Locovei, Silviu +4 more
core +2 more sources
Characterization of a Strain of Fukuyoa paulensis (Dinophyceae) from the Western Mediterranean Sea [PDF]
, 2016 17 páginas, 8 figuras, 4 tablasA single cell of the dinoflagellate genus Fukuyoa was isolated from the island of Formentera (Balearic Islands, west Mediterranean Sea), cultured, and characterized by morphological and molecular methods and toxin analyses.
David, Helena +4 more
core +1 more source
Synthesis of the ABCDEFG Ring System of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 Maitotoxin (1) continues to fascinate scientists not only because of its size and potent neurotoxicity but also due to its molecular architecture. To provide further support for its structure and facilitate fragment-based biological studies, we developed an efficient chemical synthesis of the ABCDEFG segment 3 of maitotoxin.
K C, Nicolaou +3 more
openaire +2 more sources
Recent Trends in Marine Phycotoxins from Australian Coastal Waters
Marine Drugs, 2017 Phycotoxins, which are produced by harmful microalgae and bioaccumulate in the marine food web, are of growing concern for Australia. These harmful algae pose a threat to ecosystem and human health, as well as constraining the progress of aquaculture ...
Penelope Ajani +2 more
doaj +1 more source
NLRP3: A Novel Mediator in Cardiovascular Disease
Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018 Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and other nonischemic heart diseases including diabetic ...
Wenyi Zhou +8 more
wiley +1 more source
Role of calcium channels in heavy metal toxicity [PDF]
, 2013 Cellular membranes are basically impermeable to ions and have developed specific pathways (channels, transporters or pumps) to facilitate metal translocation.
Marchetti, Carla
core +2 more sources
Cell Death‐Associated Molecular‐Pattern Molecules: Inflammatory Signaling and Control
Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014 Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self‐proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and ...
Beatriz Sangiuliano +4 more
wiley +1 more source
Arachidonic acid inhibits the store-operated Ca2+ current in rat liver cells [PDF]
, 2005 Copyright © 2005 The Biochemical SocietyVasopressin and other phospholipase-C-coupled hormones induce oscillations (waves) of [Ca2+]cyt (cytoplasmic Ca2+ concentration) in liver cells.
Putney +39 more
core +1 more source
BioMed Research International, Volume 2013, Issue 1, 2013., 2013 Crohn′s disease is a complex disease in which genome, microbiome, and environment interact to produce the immunological background of the disease. Disease in childhood is more extensive and characterized by a rapid progression, leading to severe repercussions in the course of the disorder.
Annalisa Marcuzzi +7 more
wiley +1 more source