Results 51 to 60 of about 1,556 (163)
Identification of calcium-binding proteins associated with the human sperm plasma membrane [PDF]
Background The precise composition of the human sperm plasma membrane, the molecular interactions that define domain specific functions, and the regulation of membrane associated proteins during the capacitation process, still remain to be fully ...
Soren Naaby-Hansen +89 more
core +1 more source
Abstract Exposure to cadmium results in disturbances in cell homeostasis in all living organisms. The first response to stress factors, including cadmium, is activation of signal transduction pathways that mobilize cell defense mechanisms. The aim of this review is a comparison between the signaling network triggered by Cd in plants and animals ...
Jagna Chmielowska‐Bąk, Joanna Deckert
wiley +1 more source
Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. [PDF]
Monocytes play a central role in regulating inflammation in response to infection or injury, and during auto-inflammatory diseases. Human blood contains classical, intermediate and non-classical monocyte subsets that each express characteristic patterns ...
A MacKenzie +53 more
core +1 more source
Inhibition of Maitotoxin‐Induced Ca2+ Influx in Rat Glioma C6 Cells by Brevetoxins and Synthetic Fragments of Maitotoxin [PDF]
Abstract: 45Ca2+ influx in rat glioma C6 cells induced by 0.3 nM maitotoxin (MTX) was markedly inhibited by brevetoxin A (PbTx1) and brevetoxin B (PbTx2), with EC50 values of 16 and 13 µM, respectively. This inhibition was observed immediately after addition of MTX when monitored with fura‐2, which suggests that PbTx2 directly blocks the action of MTX.
K, Konoki +5 more
openaire +2 more sources
P2X7 receptor‐mediated purinergic signaling is a well‐known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and complex chronic inflammatory disorder. The P2X7 receptor induces the release into the synovial fluid
Alberto Baroja-Mazo +2 more
wiley +1 more source
Maitotoxin, a Ca2+ channel activator candidate.
Effects of maitotoxin, the most potent marine toxin, were studied using a rat pheochromocytoma cell line, PC12h. A low concentration (10(-8) g/ml) of maitotoxin induced a profound increase in CA2+ influx into PC12h cells and the Ca2+-dependent release of [3H]norepinephrine from them.
M, Takahashi, Y, Ohizumi, T, Yasumoto
openaire +2 more sources
Abstract In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several ...
Rodolphe Lemée +73 more
wiley +1 more source
Role of the Inflammasome, IL‐1β, and IL‐18 in Bacterial Infections
The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL‐1β and IL‐18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern
Manoranjan Sahoo +4 more
wiley +1 more source
Addressing the safety of new food sources and production systems
Abstract New food sources and production systems (NFPS) are garnering much attention, driven by international trade, changing consumer preferences, potential sustainability benefits, and innovations in climate‐resilient food production systems. However, NFPS can introduce new challenges for food safety agencies and food manufacturers.
Yong Quan Tan +4 more
wiley +1 more source
The role of the inflammasome in cellular responses to toxins and bacterial effectors [PDF]
Invading pathogens are recognized by mammalian cells through dedicated receptors found either at the cell surface or in the cytoplasm. These receptors, like the trans-membrane Toll-like Receptors (TLR) or the cytosolic Nod-like Receptors (NLR), initiate ...
Freche, Barbara +2 more
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