Trends in Ostreopsis proliferation along the Northern Mediterranean coasts [PDF]
, 2011 14 pages, 6 figures, 2 tableHarmful benthic microalgae blooms represent an emergent phenomenon in temperate zones, causing health, ecological and economic concern.
Mangialajo, L. +4 more
core +1 more source
Synthesis and biological evaluation of QRSTUVWXYZA' domains of maitotoxin. [PDF]
J Am Chem Soc, 2014 The synthesis of QRSTUVWXYZA' domains 7, 8, and 9 of the highly potent marine neurotoxin maitotoxin (1), the largest secondary metabolite isolated to date, is described. The devised synthetic strategy entailed a cascade Takai-Utimoto ester olefination/ring closing metathesis to construct ring Y, a hydroxydithioketal cyclization/methylation sequence to ...
Nicolaou KC +5 more
europepmc +5 more sources
Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases [PDF]
, 2014 Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes ...
Choi, Alexander J.S., Ryter, Stefan W.
core +1 more source
Probenecid Blocks Human P2X7 Receptor-Induced Dye Uptake via a Pannexin-1 Independent Mechanism [PDF]
, 2014 P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
A Piccini +45 more
core +4 more sources
Functional and Structural Biological Methods for Palytoxin Detection [PDF]
, 2022 Palytoxin (PLTX) and its analogues are marine polyethers identified in Palythoa and Zoanthus corals, Ostreopsis dinoflagellates, and Trichodesmium cyanobacteria. Humans can be exposed to these toxins by different routes with a series of adverse effects
Carlin M. +4 more
core +1 more source
Biophysical and pharmacological characterisation of recombinant and native rat P2X7 receptors
, 2009 P2X7 receptors exhibit a mainly non-neuronal localisation on immune and glial cells and primarily function as non-selective cation channels. After prolonged or repeated exposure to agonist, functional and cellular changes occur: the formation of a ...
Lappin, Sarah Crawford +1 more
core +1 more source
Untersuchung zur Beteiligung von Proteinkinase A und Tyrosinkinasen an der Calcium-abhängigen Signaltransduktion von Glucagon-like Peptide 1(7-36)amid in Insulin-sezernierenden Zellen des endokrinen Pankreas [PDF]
, 2005 Glucagon-like Peptide-1(7-37)/(7-36)amid, GLP-1, ist ein insulinotropes intestinales Peptid-Hormon, das vor allem wegen der Verstärkung der Glukose-abhängigen Insulinsekretion, ein großes Potential bei der Therapie des Diabetes mellitus hat.
Bode, Hans-Peter (Dr.), Moormann, Birgit
core +1 more source
Design and mechanistic insight into ultrafast calcium indicators for monitoring intracellular calcium dynamics. [PDF]
, 2016 Calmodulin-based genetically encoded fluorescent calcium indicators (GCaMP-s) are powerful tools of imaging calcium dynamics from cells to freely moving animals.
A Badura +37 more
core +1 more source
Maitotoxin‐activated single calcium channels in guinea‐pig cardiac cells [PDF]
British Journal of Pharmacology, 1987 1. In order to clarify the mechanism of Ca-dependent excitatory action of maitotoxin (MTX), the most potent marine toxin known, patch-clamp techniques were used to analyse electrophysiological effects of MTX on guinea-pig isolated cardiac myocytes. 2. The whole-cell recordings showed that MTX (0.3 ng ml-1) produced a sustained inward current that was ...
M, Kobayashi, R, Ochi, Y, Ohizumi
openaire +2 more sources
Insulin trafficking in a glucose responsive engineered human liver cell line is regulated by the interaction of ATP-sensitive potassium channels and voltage- gated calcium channels [PDF]
, 2013 Type I diabetes is caused by the autoimmune destruction of pancreatic beta (â) cells [1]. Current treatment requires multiple daily injections of insulin to control blood glucose levels.
An, T +14 more
core +1 more source