Results 1 to 10 of about 235,574 (356)

Multiple Loci within the major histocompatibility complex confer risk of psoriasis. [PDF]

PLoS Genetics, 2009
Psoriasis is a common inflammatory skin disease characterized by thickened scaly red plaques. Previously we have performed a genome-wide association study (GWAS) on psoriasis with 1,359 cases and 1,400 controls, which were genotyped for 447,249 SNPs. The
Bing-Jian Feng, Liang-Dan Sun, Razieh Soltani-Arabshahi, Anne M Bowcock, Rajan P Nair, Philip Stuart, James T Elder, Steven J Schrodi, Ann B Begovich, Gonçalo R Abecasis, Xue-Jun Zhang, Kristina P Callis-Duffin, Gerald G Krueger, David E Goldgar   +13 more
doaj   +6 more sources

Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species

mBio, 2017
Development of a vaccine to protect against cryptococcosis is a priority given the enormous global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery system, we previously demonstrated that mice vaccinated with crude ...
Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Jennifer K. Lodge, Ali Akalin, Jane Homan, Gary R. Ostroff, Stuart M. Levitz   +15 more
doaj   +1 more source

HLA-check: evaluating HLA data from SNP information

BMC Bioinformatics, 2017
Background The major histocompatibility complex (MHC) region of the human genome, and specifically the human leukocyte antigen (HLA) genes, play a major role in numerous human diseases.
Marc Jeanmougin, Josselin Noirel, Cédric Coulonges, Jean-François Zagury   +3 more
doaj   +1 more source

Exploration of the Conformational Dynamics of Major Histocompatibility Complex Molecules

Frontiers in Immunology, 2017
Major histocompatibility complex (MHC) molecules are loaded with a wide variety of self- and non-self-peptides in their binding grooves and present these to T cell receptors (TCRs) in order to activate the adaptive immune system.
Saeko Yanaka, Kenji Sugase
doaj   +1 more source

Pathways of major histocompatibility complex allorecognition [PDF]

Current Opinion in Organ Transplantation, 2008
Here, we review the pathways of allorecognition and their potential relevance to the balance between regulatory and effector responses following transplantation.Transplantation between nonidentical members of the same species elicits an immune response that manifests as graft rejection or persistence.
Afzali, Ben, Lombardi, Giovanna, Lechler, Robert   +2 more
openaire   +5 more sources

Changes in blood lymphocyte subpopulations and expression of MHC-II molecules in wild mares before and after parturition

Journal of Veterinary Research, 2017
Introduction: Pregnancy is a physiological state in which the immune system undergoes certain changes. On the one hand, by depleting cell defence mechanisms, it favours development and maintenance of the pregnancy.
Krakowski Leszek, Bartoszek Przemysław, Krakowska Izabela, Stachurska Anna, Piech Tomasz, Brodzki Piotr, Wrona Zygmunt   +6 more
doaj   +1 more source

The Major Histocompatibility Complex of Old World Camels—A Synopsis

Cells, 2019
This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil, Sofia Wijkmark, Jean Pierre Elbers, Jan Oppelt, Pamela Anna Burger, Petr Horin   +5 more
doaj   +1 more source

Discovery of a Novel MHC Class I Lineage in Teleost Fish which Shows Unprecedented Levels of Ectodomain Deterioration while Possessing an Impressive Cytoplasmic Tail Motif

Cells, 2019
A unique new nonclassical MHC class I lineage was found in Teleostei (teleosts, modern bony fish, e.g., zebrafish) and Holostei (a group of primitive bony fish, e.g., spotted gar), which was designated “H” (from “hexa”) for being ...
Unni Grimholt, Kentaro Tsukamoto, Keiichiro Hashimoto, Johannes M. Dijkstra   +3 more
doaj   +1 more source

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

Cells, 2019
Fascinating about classical major histocompatibility complex (MHC) molecules is their polymorphism. The present study is a review and discussion of the fish MHC situation. The basic pattern of MHC variation in fish is similar to mammals, with MHC class I
Takuya Yamaguchi, Johannes M. Dijkstra
doaj   +1 more source

Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax infection

Frontiers in Immunology, 2016
The importance of host and parasite genetic factors in malaria resistance or susceptibility has been investigated since the middle of the last century. Nowadays, of all diseases that affect man, malaria still plays one of the highest levels of selective ...
Josué Costa Lima-Junior, Lilian Rose Pratt-Riccio   +1 more
doaj   +1 more source