Results 31 to 40 of about 680,011 (354)

The Major Histocompatibility Complex in Transplantation

Journal of Transplantation, 2012
The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the ...
Marco Antonio Ayala García, Beatriz González Yebra, Andrea Liliana López Flores, Eduardo Guaní Guerra   +3 more
doaj   +1 more source

Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA [PDF]

, 1986
Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC ...
Boral, Anthony, Buxbaum, Joel, Devlin, J., Flavell, Richard A., Kornreich, Ruth, Mellor, Andrew L., Meruelo, Daniel, Pampeno, Christine, Pellicer, Angel, Rossomando, Anthony, Silver, Jack L., Weiss, Elisabeth H.   +11 more
core   +1 more source

Endogenous versus exogenous fatty acid availability affects lysosomal acidity and MHC class II expression

Journal of Lipid Research, 2006
Although the immune system, inflammation, and cellular metabolism are linked to diseases associated with dyslipidemias, the mechanism(s) remain unclear.
S.C. Schweitzer, A.M. Reding, H.M. Patton, T.P. Sullivan, C.E. Stubbs, E. Villalobos-Menuey, S.A. Huber, M.K. Newell   +7 more
doaj   +1 more source

IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex

Nucleic Acids Res., 2016
The IPD-MHC Database project (http://www.ebi.ac.uk/ipd/mhc/) collects and expertly curates sequences of the major histocompatibility complex from non-human species and provides the infrastructure and tools to enable accurate analysis.
G. Maccari, J. Robinson, K. Ballingall, L. Guethlein, U. Grimholt, J. Kaufman, Chak-Sum Ho, N. D. Groot, P. Flicek, R. Bontrop, J. Hammond, S. Marsh   +11 more
semanticscholar   +1 more source

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

MHC Class I+/II− Dendritic Cells Induce Hapten-Specific Immune Responses In Vitro and In Vivo [PDF]

, 1978
Activation requirements and biologic properties of hapten-specific, major histocompatibility complex class I-restricted CD8+ T lymphocytes are not fully understood.
Andrea Kolesaric, Georg Stingl, Adelheid Elbe-Bürger, Bour, Cavani, Elbe, Elbe, Enk, Gorinski, Hauser, Hyman, Kalish, Kalish, Kapsenberg, Kohler, Kondo, Lenz, Lynch, Martin, Ptak, Simon, Sullivan, Tamaki, Toews, Tse, Xu   +25 more
core   +1 more source

Evolution of major histocompatibility complex gene copy number.

PLoS Computational Biology, 2019
MHC genes, which code for proteins responsible for presenting pathogen-derived antigens to the host immune system, show remarkable copy-number variation both between and within species.
Piotr Bentkowski, Jacek Radwan
doaj   +1 more source

Major histocompatibility complex: history of discovery, evolution, structure, significance in transplantation of allogeneic hematopoietic stem cells

Трансплантология (Москва), 2023
Aim. To reveal the significance of the major histocompatibility complex and the human leukocyte antigen evolutionary divergence in transplantation of allogeneic hematopoietic stem cells.
F. A. Omarova, M. Yu. Drokov, E. G. Khamaganova   +2 more
doaj   +1 more source

The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review

Journal of Clinical & Cellular Immunology, 2016
Epidemiological studies and mouse models suggest that maternal immune activation, induced clinically through prenatal exposure to one of several infectious diseases, is a risk factor in the development of schizophrenia.
Ryan Mokhtari, H. Lachman
semanticscholar   +1 more source