Results 31 to 40 of about 991,100 (420)
Трансплантология (Москва), 2023 Aim. To reveal the significance of the major histocompatibility complex and the human leukocyte antigen evolutionary divergence in transplantation of allogeneic hematopoietic stem cells.
F. A. Omarova +2 more
doaj +1 more source
Journal of Experimental Medicine, 1991 Interleukin 10 (IL-10) and viral IL-10 (v-IL-10) strongly reduced antigen-specific proliferation of human T cells and CD4+ T cell clones when monocytes were used as antigen-presenting cells.
R. D. Malefyt +9 more
semanticscholar +1 more source
Inferring HIV escape rates from multi-locus genotype data [PDF]
Front. Immunol. 4:252. 2013, 2013 Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells. Virus variants whose protein fragments are not efficiently presented on infected cells or whose fragments are ...
arxiv +1 more source
Predicting the Binding of SARS-CoV-2 Peptides to the Major Histocompatibility Complex with Recurrent Neural Networks [PDF]
arXiv, 2021 Predicting the binding of viral peptides to the major histocompatibility complex with machine learning can potentially extend the computational immunology toolkit for vaccine development, and serve as a key component in the fight against a pandemic. In this work, we adapt and extend USMPep, a recently proposed, conceptually simple prediction algorithm ...
arxiv
Frontiers in Ecology and Evolution, 2022 BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He +8 more
doaj +1 more source
Major Histocompatibility Complex and Psoriasis [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2018 Major histocompatibility complex (MHC), also known as human leukocyte antigen (HLA) in humans, is one of the most genetically diverse regions in the genome of various species. The human MHC contains about 400 genes in a ∼7.6-Mb span located on the short arm of the chromosomal region 6p21.3.
Xuejun Zhang, Fusheng Zhou
openaire +3 more sources
The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review
Journal of Clinical & Cellular Immunology, 2016 Epidemiological studies and mouse models suggest that maternal immune activation, induced clinically through prenatal exposure to one of several infectious diseases, is a risk factor in the development of schizophrenia.
Ryan Mokhtari, H. Lachman
semanticscholar +1 more source
Equine Veterinary Journal, 2016 Summary Background Allogeneic mesenchymal stem cells (MSCs) are a promising cell source for treating musculoskeletal injuries in horses. Controversy exists, however, over whether major histocompatibility complex (MHC)‐mismatched MSCs are recognised by ...
A. Berglund, L. Schnabel
semanticscholar +1 more source
The influence of T cell development on pathogen specificity and autoreactivity [PDF]
J. Stat. Phys. 149 (2012) 203-219, 2011 T cells orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors on their surface to short peptides derived from foreign proteins bound to protein products of the major histocompatibility (MHC) gene products, which are displayed on the surface of antigen presenting cells.
arxiv +1 more source
Analysis of Major Histocompatibility Complex (MHC) Immunopeptidomes Using Mass Spectrometry*
Molecular & Cellular Proteomics, 2015 The myriad of peptides presented at the cell surface by class I and class II major histocompatibility complex (MHC) molecules are referred to as the immunopeptidome and are of great importance for basic and translational science.
E. Caron +5 more
semanticscholar +1 more source