Human Vaccines & Immunotherapeutics, 2021 Malaria vaccines hold significant promise for life-saving benefit, especially to children who bear the major burden of malaria mortality. The RTS,S/AS01 malaria vaccine provides moderate efficacy and is being tested in implementation studies. In parallel,
Matthew B. Laurens
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Malaria Vaccines: From the Past towards the mRNA Vaccine Era [PDF]
Vaccines, 2023 Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease transmitted by infected mosquitoes. Malaria remains a major global health challenge, particularly in endemic regions.
Maria E. Tsoumani +2 more
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Malaria Vaccines: Current Achievements and Path Forward [PDF]
VaccinesMalaria remains a significant global health challenge. Although the recent approval of the liver-stage vaccines RTS, S and R21 marks significant progress in malaria control, challenges remain in achieving long-lasting and broad protection. In this review,
Jiayan Chen +3 more
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Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects [PDF]
Tropical Medicine and Health, 2023 Background The world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science.
Amal A. El-Moamly, Mohamed A. El-Sweify
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A roadmap of priority evidence gaps for the co-implementation of malaria vaccines and perennial malaria chemoprevention [PDF]
Malaria JournalProgress in malaria control will rely on deployment and effective targeting of combinations of interventions, including malaria vaccines and perennial malaria chemoprevention (PMC).
Jane Grant +1 more
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Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions [PDF]
BiomedicinesThe journey toward a viable malaria vaccine, initiated in 1965, reached a major milestone in 2021 with the WHO’s endorsement of RTS,S/AS01, a recombinant protein-based malaria vaccine.
Rajesh Perumbilavil Kaithamanakallam +10 more
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Whole-sporozoite malaria vaccines: where we are, where we are going [PDF]
EMBO Molecular MedicineThe malaria vaccination landscape has seen significant advancements with the recent endorsement of RTS,S/AS01 and R21/Matrix-M vaccines, which target the pre-erythrocytic stages of Plasmodium falciparum (Pf) infection.
Diana Moita, Miguel Prudêncio
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Knowledge and willingness towards malaria vaccines among caregivers in Dar es Salaam, Tanzania [PDF]
Malaria JournalBackground Tanzania is a malaria-endemic country that relies solely on anti-malarial drugs and vector control measures, including insecticide-treated bed nets and indoor residual spraying.
Felista Mwingira +2 more
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Unlocking the potential of novel RTS, S/AS01, and R21/Matrix‐M™ malaria vaccines in African nations [PDF]
Health Science ReportsIntroduction Mass malaria vaccination, rather than vaccinating only children below age 5, has been proven to have the potential to reduce morbidity and mortality among those vaccinated, both young and old. Addressing vaccine scepticism and misinformation
Malik Olatunde Oduoye +11 more
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Physicians’ knowledge of, and willingness to encourage caregivers to partake in the RTS S/AS01 and R21 matrix M malaria vaccines roll out – a national survey in Nigeria [PDF]
BMC Infectious DiseasesBackground The malaria parasite, caused by Plasmodium falciparum, continues to pose serious public health threats in tropical and sub-tropical regions of the world, despite the availability of malaria vaccine.
Mary Aigbiremo Oboh +3 more
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