Results 31 to 40 of about 78,708 (218)
Vaccine innovation, translational research and the management of knowledge accumulation [PDF]
, 2012 What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving ...
Andre +86 more
core +2 more sources
MALVAC 2012 scientific forum: accelerating development of second-generation malaria vaccines
Malaria Journal, 2012 The World Health Organization (WHO) convened a malaria vaccines committee (MALVAC) scientific forum from 20 to 21 February 2012 in Geneva, Switzerland, to review the global malaria vaccine portfolio, to gain consensus on approaches to accelerate second ...
Vannice Kirsten S +3 more
doaj +1 more source
Future use-cases of vaccines in malaria control and elimination
Parasite Epidemiology and Control, 2020 Malaria burden has significantly changed or decreased over the last 20 years, however, it remains an important health problem requiring the rigorous application of existing tools and approaches, as well as the development and use of new interventions.
Melissa A. Penny +4 more
doaj +1 more source
Optimal control analysis of hepatocytic-erythrocytic dynamics of Plasmodium falciparum malaria
Infectious Disease Modelling, 2022 This paper presents an in-host malaria model subject to anti-malarial drug treatment and malaria vaccine antigens combinations. Pontryagin's Maximum Principle is applied to establish optimal control strategies against infected erythrocytes, infected ...
Titus Okello Orwa +2 more
doaj +1 more source
Dendritic cells in plasmodium infection [PDF]
, 2008 Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to ...
Alonso +15 more
core +2 more sources
The Lancet, 2004 Large gains in the reduction of malaria mortality in the early 20th century were lost in subsequent decades. Malaria now kills 2-3 million people yearly. Implementation of malaria control technologies such as insecticide-treated bednets and chemotherapy could reduce mortality substantially, but an effective malaria vaccine is also needed.
Moorthy, V, Good, M, Hill, A
openaire +3 more sources
Nature Communications, 2018 Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria.
Alvaro Baeza Garcia +13 more
doaj +1 more source
Malaria vaccines 1985-2005: a full circle?
, 2005 Few who were actively engaged in malaria vaccine research 20 years ago (including myself) would have imagined that, in 2005, there would still be a prediction of a 10-20-year horizon before vaccines become part of malaria-control strategies.
Targett, Geoffrey A
core +1 more source
Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice.
PLoS ONE, 2011 BackgroundGiven the considerable geographic overlap in the endemic regions for malaria and tuberculosis, it is probable that co-infections with Mycobacterium tuberculosis and Plasmodium species are prevalent.
Marcela Parra +9 more
doaj +1 more source
Theoretical implications of a pre-erythrocytic Plasmodium vivax vaccine for preventing relapses [PDF]
, 2017 Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum.
Amino, R, Mueller, I, White, MT
core +3 more sources