Results 51 to 60 of about 78,708 (218)

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites. [PDF]

PLoS ONE, 2012
Live attenuated malaria vaccines are more potent than the recombinant protein, bacterial or viral platform vaccines that have been tested, and an attenuated sporozoite vaccine against falciparum malaria is being developed for humans.
Walter R Weiss, Chengyong George Jiang
doaj   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, EarlyView.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source

Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal

Scientific Reports
The Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) is a promising target as a next-generation blood-stage malaria vaccine and together with PCRCR complex members, the reticulocyte binding-like homologous protein 5 (PfRh5) and the Rh5 ...
Aboubacar Ba, Laty Gaye Thiam, Mariama Nicole Pouye, Yicheng Guo, Saurabh D. Patel, Seynabou Diouf Sene, Fatoumata Diallo, Rebecca Li, Awa Cisse, Noemi Guerra, Safia Laqqa, Khadidiatou Mangou, Adam J. Moore, Bacary Djilocalisse Sadio, Jean Louis Abdourahim Ndiaye, Alassane Mbengue, Ines Vigan-Womas, Zizhang Sheng, Lawrence Shapiro, Amy K. Bei   +19 more
doaj   +1 more source

A Critical Review on Human Malaria and Schistosomiasis Vaccines: Current State, Recent Advancements, and Developments

Vaccines, 2023
Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of morbidity and mortality worldwide. Co-infections of these two parasites are common in the tropics, where both diseases are endemic.
Arif Jamal Siddiqui, Jyoti Bhardwaj, Juhi Saxena, Sadaf Jahan, Mejdi Snoussi, Fevzi Bardakci, Riadh Badraoui, Mohd Adnan   +7 more
doaj   +1 more source

Epidemiology of Malaria in an Area Prepared for Clinical Trials in Korogwe, North-eastern Tanzania. [PDF]

, 2009
Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria ...
Acleus S Rutta, AE Mnzava, AM Ronn, Bruno P Mmbando, CA Maxwell, CJ Drakeley, CJ Drakeley, Deus S Ishengoma, DG Heppner Jr, E Kahigwa, Filbert Francis, H Dirren, Hamisi A Msangeni, J Keiser, JC Beier, JG Siri, JP Lusingu, JP Lusingu, JP Shott, KN Suh, M Alifrangis, Martha M Lemnge, Mathias L Kamugisha, Method D Segeja, Misago D Seth, PB Bloland, R Bodker, R Bodker, RW Snow, S Vyas, Samwel H Sembuche, V Robert, WL Kilama, WL Kilama   +33 more
core   +3 more sources

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

Development of replication-deficient adenovirus malaria vaccines

Expert Review of Vaccines, 2017
Introduction: Malaria remains a major threat to endemic populations and travelers, including military personnel to these areas. A malaria vaccine is feasible, as radiation attenuated sporozoites induce nearly 100% efficacy.
Michael R. Hollingdale, Martha Sedegah, Keith Limbach   +2 more
doaj   +1 more source

Is vaccination the only option for possible global malaria eradication? [PDF]

, 2006
In the last century, vaccines, together with the discovery of antibiotics have been powerful tools in the management of infectious diseases. Both were of particular importance in reducing the morbidity and mortality associated with infections prevailing ...
Tonna, Ivan
core