Results 61 to 70 of about 78,708 (218)

Domestic and International Health Expenditure and Health and Healthcare Use: Evidence From Mozambique

Health Economics, EarlyView.
ABSTRACT Evidence on the relationship between public health expenditure and health is mixed and particularly scarce for low‐income countries. Existing studies overlook the subnational distribution of expenditure and rarely distinguish between sources and governance over funding.
Eliana Chavarría‐Pino, Laura Anselmi, Matt Sutton, Sérgio Chicumbe   +3 more
wiley   +1 more source

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, EarlyView.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source

Negative immunomodulation by parasitic infections in the human response to vaccines

Journal of Infection in Developing Countries, 2018
Parasitic infections are an important cause of global morbidity and mortality and are highly prevalent in "underdeveloped" countries. The presence of parasitic infections is associated with modulation of the immune system and changes in the response to ...
Catalina Alvarez-Larrotta, Eliana María Arango, Jaime Carmona-Fonseca   +2 more
doaj   +1 more source

Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission

npj Vaccines, 2021
Despite considerable effort, malaria remains a major public health burden. Malaria is caused by five Plasmodium species and is transmitted to humans via the female Anopheles mosquito. The development of malaria vaccines against the liver and blood stages
Yacob Keleta, Julian Ramelow, Liwang Cui, Jun Li   +3 more
doaj   +1 more source

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
BackgroundPolymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development.
Anders, Robin F., Barry, Alyssa E., Beeson, James G., Cross, Nadia J., Drew, Damien R., Dutta, Sheetij, Elliott, Salenna R., Hodder, Anthony N., Marsh, Kevin, Mueller, Ivo, Mugyenyi, Cleopatra K., Osier, Faith, Richards, Jack S., Senn, Nicolas, Siba, Peter M., Stanisic, Danielle I., Terheggen, Ulrich   +16 more
core   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Subnational introduction of the RTS,S/AS01E malaria vaccine into routine immunization: experience and lessons from the three pilot countries

Malaria Journal
Background In October 2021, the World Health Organization (WHO) recommended the RTS,S/AS01E (RTS,S) malaria vaccine for the prevention of Plasmodium falciparum malaria in children living in endemic areas informed by evidence from the subnational pilot ...
Rose Jalang’o, Kwame Amponsa-Achiano, Mike Chisema, Keziah Malm, Lydiah Khalayi, Brenda Mhone, Wahjib Mohammed, Franklin Asiedu-Bekoe, Adam Haji, Josephine Njoroge, Boston Zimba, Esther Chirwa, Peter O. Tweneboah, Jackson Sillah, Mgaywa G. M. D. Magafu, Cynthia Bergstrom, Tracey Goodman, Jenny Walldorf, Kristen Kelleher, Eliane Pellaux-Furrer, Mary J. Hamel, Michael R. Adjei, Rafiq N. A. Okine   +22 more
doaj   +1 more source

Allelic forms of merozoite surface protein-3 in Plasmodium falciparum isolates from southeast of Iran [PDF]

, 2014
Background: Genetic diversity has provided Plasmodium falciparum with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites.
Ebrahimzadeh, A., Jamshidi, A., Mohammadi, S.   +2 more
core   +2 more sources

Cell membrane‐coated nanoparticles for dermatological diseases

VIEW, EarlyView.
Skin disorders are challenging to treat due to complex barrier functions and limited conventional therapies. Biomimetic cell membrane‐coated nanoparticles (CM‐NPs) offer a superior nanomedicine approach by evading immune detection and enabling precise targeting.
Shuaijun Zou, Baojie Zhang, Yuanjie Zhu
wiley   +1 more source

The extraordinary evolutionary history of the reticuloendotheliosis viruses [PDF]

, 2013
The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely
A Katzourakis, A Katzourakis, A Stamatakis, AC van der Kuyl, AD Yoder, AL Hughes, AM Awad, AM Fadly, Anna Maria Niewiadomska, Bill Sugden, BR Burmester, C Feschotte, C Hertig, CG Ludford, CG Ludford, CN Dren, CN Dren, CN Dren, CR Parrish, CY Kang, CY Lin, DC Nickle, DH Huson, DH Ley, DJ McGeoch, DS Arathy, DW Trampel, E Prukner-Radovcic, EH Dearborn, F Abascal, F Rodriguez, FR Robinson, H Koyama, HC Carlson, HG Purchase, HM Koo, I Davidson, IS Diallo, IS Diallo, J Hanson, J Li, J Martin, JJ Solomon, JP Stoye, JP Vanderberg, JS McDougall, K Nyakatura, KA Schat, KM Moore, LA Terzian, LE Hayes, LJ Yu, LT Coggeshall, M Barbacid, M Garcia, MJ Peterson, MK Cook, ML Drew, MR Patel, MW Dimmic, MX Motha, N Ratnamohan, N Yuasa, P Singh, PE Miller, PS Paul, PS Sarma, Q Liu, R Crespo, R Gifford, R Isfort, RA Weiss, RB Franklin, RB Franklin, RJ Isfort, RL Witter, RL Witter, RL Witter, RM Corwin, Robert J. Gifford, SB Hitchner, SK Biswas, SL Kosakovsky Pond, T Barbosa, T Tadese, TJ Kim, TM Grimes, VN Kewalramani, W Trager, WG Conway, WH Cheng, Y Wang, Z Cheng, Z Cui, Z Yang, É Brumpt   +95 more
core   +3 more sources