Results 81 to 90 of about 78,708 (218)

When Regulation Travels: Distrust and Disrespect

Regulation &Governance, EarlyView.
ABSTRACT Endeavoring to avoid the pitfalls of being too trusting of regulated entities' compliance claims, regulators sometimes create regulatory systems with elaborate requirements for verification. But as these accountability and verification regimes attempt to circumvent one set of problems, they may inadvertently create others.
Carol A. Heimer
wiley   +1 more source

Assessment of Antibodies Induced by Multivalent Transmission-Blocking Malaria Vaccines

Frontiers in Immunology, 2018
A malaria transmission-blocking vaccine would be a critical tool in achieving malaria elimination and eradication. By using chimpanzee adenovirus serotype 63 and modified vaccinia virus Ankara viral vectored vaccines, we investigated whether ...
Vinay Menon, Melissa C. Kapulu, Iona Taylor, Kerry Jewell, Yuanyuan Li, Fergal Hill, Carole A. Long, Kazutoyo Miura, Sumi Biswas   +8 more
doaj   +1 more source

Using unmanned aerial vehicles (drones) to improve access to blood in low‐ and middle‐income countries: Current challenges and opportunities

Vox Sanguinis, EarlyView.
Abstract Blood transfusion is life‐saving for patients in emergencies, but low‐ and middle‐income countries (LMICs) often face a severe shortage of banked blood. Establishing blood banks in rural areas presents substantial logistical and economic challenges for many LMICs.
Suvro Sankha Datta, Ritwick Mondal, Shramana Deb, Giuseppe Tortora, Angela Pirri   +4 more
wiley   +1 more source

Creative and Adaptive Solutions for Early Diagnosis of Sickle Cell Disease in Sub‐Saharan Africa

American Journal of Hematology, Volume 101, Issue S1, Page 17-32, April 2026.
ABSTRACT Many of the children with sickle cell disease born in sub‐Saharan Africa remain undiagnosed and untreated. Increasing capacity and infrastructure to support diagnostic and screening programs in high income countries have enabled near universal survival into adulthood.
Luke R. Smart, Catherine I. Segbefia, Isaac Odame   +2 more
wiley   +1 more source

The Epidemiology of Sickle Cell Disease in Sub‐Saharan Africa: Current Knowledge and Gaps to be Filled

American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.
What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque, Leon Tshilolo, Thomas N. Williams   +2 more
wiley   +1 more source

Malaria Vaccine Development: The Need for Novel Approaches: A Review Article

Iranian Journal of Parasitology, 2018
Background: Although rigorous efforts have substantially decreased the malaria burden through decades, it still threatens the lives of millions of children. Development of an effective vaccine can provide important approach in malaria control strategies.
Shima MAHMOUDI, Hossein KESHAVARZ
doaj  

Advances in transmission-blocking vaccines against Plasmodium falciparum and Plasmodium vivax

Expert Review of Vaccines
Introduction The World Health Organization has recommended two pre-erythrocytic malaria vaccines targeting Plasmodium falciparum. However, there is currently no vaccine available for Plasmodium vivax, the second leading cause of malaria.
Mayumi Tachibana, Eizo Takashima, Motomi Torii, Yimin Wu, Jetsumon Sattabongkot, Takafumi Tsuboi   +5 more
doaj   +1 more source

The role of T cells in sepsis of distinct infectious aetiologies

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu, Bijun Zhu, Wanxin Duan, Ruixiang Kang, Xiangdong Wang, Liyang Li   +5 more
wiley   +1 more source

A landscape review of malaria vaccine candidates in the pipeline

Tropical Diseases, Travel Medicine and Vaccines
Background Globally, malaria continues to pose a major health challenge, with approximately 247 million cases of the illness and 627,000 deaths reported in 2021.
Yusuf Amuda Tajudeen, Habeebullah Jayeola Oladipo, Sodiq Inaolaji Yusuff, Samuel O. Abimbola, Muritala Abdulkadir, Iyiola Olatunji Oladunjoye, Abass Olawale Omotosho, Oluwaseyi Muyiwa Egbewande, Hameedat Damilola Shittu, Rashidat Onyinoyi Yusuf, Oluwatosin Ogundipe, Abdulbasit Opeyemi Muili, Abdullateef Opeyemi Afolabi, Salwa M. A. Dahesh, Marwa Ahmed Mahmoud Gameil, Mona Said El-Sherbini   +15 more
doaj   +1 more source

Identification of a growth-inhibitory epitope in PfRipr5, a malaria vaccine candidate against Plasmodium falciparum

Frontiers in Immunology
BackgroundThe Plasmodium falciparum Rh5-interacting protein (PfRipr) is a key component of the pentameric PTRAMP-CSS-PfRipr-CyRPA-RH5 (PCRCR) complex, which is essential for erythrocyte invasion. Antibodies against PfRipr can inhibit parasite growth, but
Hikaru Nagaoka, Akihisa Fukushima, Takafumi Tsuboi, Eizo Takashima   +3 more
doaj   +1 more source