Results 71 to 80 of about 43,444 (345)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Study of the Activity and Toxicity of New Antibacterial Agents Based on Triindolylmethane Derivatives in vivo

Антибиотики и Химиотерапия, 2020
Biological properties of new synthetic triindolylmethylium antibiotics of the triindolylmethane group, including compounds containing a maleimide fragment in the structure, are studied.
E. P. Mirchink, E. B. Isakova, S. N. Lavrenov, A. Yu. Simonov, V. A. Golibrodo, A. A. Panov, O. P. Bychkova, V. V. Tatarskiy, A. S. Trenin   +8 more
doaj  

Chromone Derivatives CM3a Potently Eradicate Staphylococcus aureus Biofilms by Inhibiting Cell Adherence

Infection and Drug Resistance, 2021
Qing Zhan,1 Yanlei Xu,1 Lingling Zhan,2 Bingjie Wang,3 Yinjuan Guo,3,4 Xiaocui Wu,3,4 Wenxiu Ai,5 Zengqiang Song,6 Fangyou Yu3,4 1Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, 330006 ...
Zhan Q, Xu Y, Zhan L, Wang B, Guo Y, Wu X, Ai W, Song Z, Yu F   +8 more
doaj  

Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery

Liposomes are promising spherical vesicles for topical drug delivery to the eye. Several types of vesicles were formulated in this study, including conventional, PEGylated, and maleimide-decorated PEGylated liposomes.
Sergey K. Filippov (1296339), Daulet B. Kaldybekov (5687018), Aurel Radulescu (1544251), Roman V. Moiseev (14052728), Vitaliy V. Khutoryanskiy (1292658)   +4 more
core   +1 more source

Effect of substituent and solvent on the structure and spectral properties of maleimide derivatives

, 2011
The maximum absorption wavelength View the MathML source, emission wavelength (λem) and the related oscillator strength (f) of the maleimides in the ground and first excited states were calculated by using the DFT, CIS and the time-dependent density ...
王伯昌
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Copper(II)-mediated N-terminal modification of proteins with maleimide derivatives [PDF]

Maleimide derivatives are privileged reagents for the chemical modification of proteins via the Michael addition of cysteine due to their selectivity, reaction rate, and commercial availability.
Kazuaki , Taguchi, Yuki, Wada, Shuhei, Higashibayashi, Kengo, Hanaya, Masaki, Kawano   +4 more
core   +2 more sources

Versatile Detection of Cellular Protein via Fluorescence Anisotropy

Advanced Science, EarlyView.
Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang, Yuan‐Ping Wei, Ricky Ruiqi Ma, Na Wei, Tammy Zihan Zhou, Hilary Kung‐Yu Ho, Zafar Iqbal Bhat, Iqra Ishrat, Xiaoyu Li, Judy Wai Ping Yam, Yung Hou Wong, Qiankun Wang, Justin L. Tan   +12 more
wiley   +1 more source

Bioresponsive albumin-conjugated paclitaxel prodrugs for cancer therapy

Drug Delivery, 2018
The efficacy of traditional chemotherapy often suffers from rapid clearance and off-target toxicity. Drug delivery systems and controlled release are applied to improve the therapeutic efficiencies of small-molecule drugs.
Jincheng Yang, Qingzhi Lv, Wei Wei, Zhengtao Yang, Jiajun Dong, Ruoshi Zhang, Qiming Kan, Zhonggui He, Youjun Xu   +8 more
doaj   +1 more source

Maleimide-Dimethylfuran exo Adducts: Effective Maleimide Protection in the Synthesis of Oligonucleotide Conjugates

, 2016
The reaction of maleimide-containing compounds with 2,5-dimethylfuran gives a mixture of exo and endo isomers from which the exo cycloadduct can be easily isolated taking advantage of its stability in concentrated aqueous ammonia.
Enrique Pedroso (61530), Anna Grandas (61531), Albert Sánchez (1958743)   +2 more
core   +1 more source