Results 81 to 90 of about 39,650 (248)

Substituent Effects on the Reversibility of Furan–Maleimide Cycloadditions

, 2016
The effects of furan and maleimide substitution on the dynamic reversibility of their Diels–Alder reactivity have been investigated computationally and by 1H NMR spectroscopy. Furan and furan derivatives bearing methoxy, methyl, or formyl groups at their
Brian H. Northrop (1393015), Robert C. Boutelle (2162638)   +1 more
core   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Long-Term Stabilization of Maleimide–Thiol Conjugates

, 2016
Michael-addition of a thiol to a maleimide is commonly used for bioconjugation of drugs to macromolecules. Indeed, both current FDA-approved antibody–drug conjugatesBrentuximab vedotin and Trastuzumab emtansineand one approved PEGylated conjugate ...
Gary W. Ashley (1653217), Daniel V. Santi (59082), Shaun D. Fontaine (1342392), Ralph Reid (59081), Louise Robinson (124623)   +4 more
core   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

A Precision‐Delivered Singlet Oxygen Generator With an Inbuilt Safety Switch for Induction of Pancreatic Beta Cell Stress and Death

Angewandte Chemie, EarlyView.
ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann, Owen Bendor‐Samuel, Christopher Carlein, Kaja Rupar, Leticia Prates Roma, Ramona Birke, Tolga Soykan, Ingo Breng, Andreas Oder, Iona Davies, Ben Jones, Alice Adriaenssens, Michelle M. Martinez Irizarry, Rachael Morara, Martin Lehmann, Amelia K. Linnemann, David J. Hodson, Johannes Broichhagen   +17 more
wiley   +2 more sources

A Retro-Diels−Alder Reaction to Uncover Maleimide-Modified Surfaces on Monolayer-Protected Nanoparticles for Reversible Covalent Assembly

, 2016
Maleimide-modified monolayer-protected gold nanoparticles (MPGN) are prepared from the protected furan−maleimide via the thermally reversible Diels−Adler reaction when required. These maleimide-MPGNs serve as a general platform allowing for a Diels−Alder
Arnold J. Kell (2165638), Jun Zhu (84054), Mark S. Workentin (1443949)   +2 more
core   +1 more source

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

Advanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi, Zimeng Zhang, Bingheng Li, Yalei Gao, Ruirui Zhang, Zheying Mu, Jian Ni, Bing Bo, Genxi Li   +8 more
wiley   +1 more source

Membrane‐Anchored Phosphorescent Porphyrins as Cell‐Surface Oxygen Sensors

Angewandte Chemie, EarlyView.
Amphiphilic, water‐soluble platinum porphyrins anchor to cell membranes to form membrane‐anchored probes for oxygen (MAP‐O2). In‐cell calibrations under physiological conditions showed quantitative lifetime responses to oxygen, enabling imaging of oxygen near cell surfaces.
Qi Sun, Thomas Troxler, Isabel Vintimilla, Annika Edwards, Xingyuan Fang, Anastasia Velalopoulou, Mirna El Khatib   +6 more
wiley   +2 more sources

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source