Results 41 to 50 of about 18,744 (300)
Beilstein Journal of Organic Chemistry, 2017 Diastereoselective radical coupling was achieved with chiral auxiliaries. The radicals were generated by anodic decarboxylation of five malonic acid derivatives. These were prepared from benzyl malonates and four menthol auxiliaries.
Matthias C. Letzel +2 more
doaj +1 more source
Charge transport through a single molecule of trans-1-bis-diazofluorene [60]fullerene [PDF]
, 2017 Fullerenes have attracted interest for their possible applications in various electronic, biological, and optoelectronic devices. However, for efficient use in such devices, a suitable anchoring group has to be employed that forms well-defined and stable
Aravena, Daniel +9 more
core +3 more sources
, 2010 International audienceA new method has been developed for the enantioselective synthesis of highly functionalised cyclopentanes bearing up to three stereogenic centres with very high stereoselectivity.
Bonne, Damien +4 more
core +3 more sources
Diastereoselective conjugate addition of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates [PDF]
, 2014 International audienceThe addition of the potassium salt of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates under various conditions is reported. Very good diastereoselectivities (> 90% de) were obtained in several cases. Conversion of one of
Capra, Julien +4 more
core +2 more sources
Therapeutic efficacy study of novel 5-FU-loaded PMM 2.1.2-based microspheres on C6 glioma [PDF]
, 2003 The aim of this study was to evaluate the potential of poly(methylidene malonate 2.1.2) as a new drug delivery system to the central nervous system.
A. Vonarbourg +7 more
core +3 more sources
Advanced Synthesis &Catalysis, EarlyView.An unprecedent dual catalytic nanophotocatalytic and asymmetric organocatalytic system for the α‐functionalization of aldehydes is developed using carbon nanodots as photosensitizers. The optimized methodology yields the alkylated products with up to 94% yield and up to 98:2 e.r., evidencing the possible recycling of the nanocatalysts.
Antonio Di Sabato +9 more
wiley +1 more source
Journal of Organic Chemistry, 2016 Highly enantioselective Michael addition of malonates to enones catalyzed by dipeptide-derived multifunctional phosphonium salts has been developed. The newly established catalytic system was characterized with its wide substrate scope featured with ...
Dongdong Cao +5 more
semanticscholar +1 more source
Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates [PDF]
, 2016 As α-carboxy nucleoside phosphonates (α-CNPs) have demonstrated a novel mode of action of HIV-1 reverse transcriptase inhibition, structurally related derivatives were synthesized, namely the malonate 2, the unsaturated and saturated bisphosphonates 3 ...
Arnold, Eddy +6 more
core +1 more source
Transition metal-free, visible light-mediated radical cyclisation of malonyl radicals onto 5-ring heteroaromatics [PDF]
, 2022 Annulated heteroaromatics can be accessed through the addition of malonyl radicals onto heterocycles. Current methods are applicable to electron-rich heteroaromatics and reliant on transition metals or toxic tin reagents.
Burton, Jonathan W +3 more
core +2 more sources
Advanced Science, EarlyView.This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen +11 more
wiley +1 more source