Results 211 to 220 of about 204,248 (294)

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source

METTL3-m6A-SLC25A11 Axis Promotes Chronic Hypoxia-Induced Cardiomyocyte Ferroptosis. [PDF]

J Am Heart Assoc
Li Y, Xia J, Wei Y, He M, He G, Zhu Y.
europepmc   +1 more source

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

Genotypic variability and trait associations for cold stress tolerance in cultivated chickpea (Cicer arietinum L.) during the reproductive stage. [PDF]

PLoS One
Padhiar D, Kaur S, Parida SK, Jha UC, Shama KD, Prasad PVV, Siddique KHM, Nayyar H.   +7 more
europepmc   +1 more source

USP54 Promotes Ferroptosis in Non‐Small Cell Lung Cancer by Mediating FOXA2 Deubiquitination and Enhancing ACSL4 Transcription

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei, Yong‐Ping Liu, Chun‐Dong Gu, Shi‐Lei Zhao, Li Feng, Jian‐Rong Yu   +5 more
wiley   +1 more source

Salivary Oxidative Stress Biomarkers in Peri-Implant Disease: A Systematic Review and Meta-Analysis. [PDF]

Int J Mol Sci
Popa PȘ, Popa GV, Earar K, Popa-Cazacu CE, Matei MN.   +4 more
europepmc   +1 more source

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Melatonin regulates Sirt1/Nrf2/GPX4 pathway to inhibit ferroptosis and alleviate myocardial injury caused by sepsis. [PDF]

World J Cardiol
Zeng M, Li Q, Li L, Xiang CF, Wang YJ.
europepmc   +1 more source

EVALUATION OF MALONDIALDEHYDE LEVELS

, 2023
Miyamoto, Sayuri, Almeida, Eduardo Alves de, Nogueira, Lilian, Gennari de Medeiros, Marisa Helena, Di Mascio, Paolo, Abele, D., VazquezMedina, J. P., ZentenoSavin, T.   +7 more
openaire   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source