Results 41 to 50 of about 245,355 (304)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Thiamethoxam Application Improves Yield and Drought Resistance of Potatoes (Solanum tuberosum L.)

Plants
(1) Background: Potato is the most important tuber crop in the world that can contribute to food security. However, the crop has been shown to be sensitive to drought and its yields decline significantly during successive periods of stress.
Hailong Qiu, Chao Sun, Richard Dormatey, Jiangping Bai, Zhenzhen Bi, Yuhui Liu, Zhen Liu, Jingui Wei, Shoufa Mao, Panfeng Yao   +9 more
doaj   +1 more source

Evaluation of anticataract potential of Triphala in selenite-induced cataract: In vitro and in vivo studies

Journal of Ayurveda and Integrative Medicine, 2010
Triphala (TP) is composed of Emblica officinalis, Terminalia chebula, and Terminalia belerica. The present study was undertaken to evaluate its anticataract potential in vitro and in vivo in a selenite-induced experimental model of cataract.
Suresh Kumar Gupta, V Kalaiselvan, Sushma Srivastava, Shyam S Agrawal, Rohit Saxena   +4 more
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Comprehensive Assessment of Alfalfa Aluminum Stress Resistance Using Growth and Physiological Trait Analysis

Agriculture
Alfalfa (Medicago sativa L.) is an important perennial leguminous forage; however, its high sensitivity to aluminum (Al) stress severely restricts its cultivation in regions with acidic soil. Therefore, this study conducted an integrated assessment of Al
Nannan Tang, Xiangming Zeng, Jizhi Wei, Zhou Li, Xuechun Zhao, Jihui Chen, Xinyao Gu, Chao Chen, Rui Dong   +8 more
doaj   +1 more source

Effects of Ionizing and Non-Ionizing Radiation on Oxidative Stress and the Total Antioxidant Status in Humans Working in Radiation Environments

Bezmiâlem Science, 2016
Objective:This study was conducted to investigate the effects of ionizing radiation (IR) and non-ionizing radiation (NIR) on oxidative stress and the total antioxidant status (TAS) in men working in radiation environments.Methods:The serum values of ...
Hakim ÇELİK, İsmail KOYUNCU, Ali Ziya KARAKILÇIK, Ataman GÖNEL, Davud MUSA   +4 more
doaj   +1 more source

Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study

Chinese Journal of Physiology, 2021
This study aimed to assess the effect of Vitamin C on blood pressure (BP), and subsequently on oxidative stress and nitric oxide (NO) release, following the low-intensity exercise in the patients.
Chongchira Boonthongkaew, Terdthai Tong-Un, Yupaporn Kanpetta, Nisa Chaungchot, Chanvit Leelayuwat, Naruemon Leelayuwat   +5 more
doaj   +1 more source

Malondialdehyde interferes with the formation and detection of primary carbonyls in oxidized proteins

Redox Biology, 2019
Carbonylation is one of the most remarkable expressions of the oxidative damage to proteins and the DNPH method the most common procedure to assess protein oxidation in biological samples.
M. Estévez, P. Padilla, L. Carvalho, Lourdes Martín, A. Carrapiso, J. Delgado   +5 more
semanticscholar   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source