Results 71 to 80 of about 245,355 (304)

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Tuber indicum colonization enhances plant drought tolerance by modifying physiological, rhizosphere metabolic and bacterial community responses in Pinus armandii

Frontiers in Plant Science
Tuber indicum has been extensively investigated in the fields of ecology, mycorrhizal synthesis with various plant species, and cultivation. Its impacts on plant physiological and metabolic responses under different water regimes remain unclear. Here, T.
Lanlan Huang, Lanlan Huang, Shanping Wan, Yong Liu, Jian Zhan, Jian Zhan, Faming Zhang, Hui Yang, Fengming Zhang, Fengming Zhang, Xuedan Xie, Xiaofei Shi, Xiaofei Shi, Yanliang Wang, Fuqiang Yu   +14 more
doaj   +1 more source

Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study

SAGE Open Medicine, 2018
Objectives: Major depressive disorder is diagnosed on the basis of patient’s self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this.
M. R. Islam, Md. Reazul Islam, Imtiaz Ahmed, Abdul Moktadir, Z. Nahar, Mohammad Safiqul Islam, S. F. Shahid, S. N. Islam, Md. Saiful Islam, A. Hasnat   +9 more
semanticscholar   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Study of Lipid peroxidation Marker (MDA) and Vitamin C in Pregnancy-Induced Hypertension [PDF]

Journal of Sharif Medical & Dental College, 2018
Objective: To determine the levels of malondialdehyde (MDA) and vitamin C in hypertensive pregnant women as compared to normotensive pregnant women and non-pregnant control subjects.
Ghazal Mansoor, Rabia Sattar, Sana Qanber , Ejaz Ahmed, Hassan Shafique, Ayesha Zahid   +5 more
doaj  

Acupuncture inhibits Notch1 and Hes1 protein expression in the basal ganglia of rats with cerebral hemorrhage

Neural Regeneration Research, 2015
Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the
Wei Zou, Qiu-xin Chen, Xiao-wei Sun, Qing-bin Chi, Hong-yu Kuang, Xue-ping Yu, Xiao-hong Dai   +6 more
doaj   +1 more source

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source

The Curative Activity of Isolated Fraction from Spathodea campanulata Beauv Stem Bark on Rat’s Exposed to Benzopyrene

Journal of Tropical Life Science, 2014
This paper reports a screening results of the secondary metabolites composed in Spathodea campanulata Beauv stem bark, evaluate inhibiting activity of malondialdehyde (MDA) on rat’s cancer model exposed with benzopyrene, and ...
Masruri Masruri, Mohamad Lutfillah, Ady Sumaryanto, Rurini Retnowati, Aulanni'am Aulanni'am   +4 more
doaj  

Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients

Brain Sciences, 2017
This review focuses on biomarkers associated with the outcome of traumatic brain injury (TBI) patients, such as caspase-3; total antioxidant capacity; melatonin; S100B protein; glial fibrillary acidic protein (GFAP); glutamate; lactate; brain-derived ...
Leonardo Lorente
doaj   +1 more source