Results 71 to 80 of about 188,625 (306)

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan   +10 more
wiley   +1 more source

The effects of eccentric muscle damage on malondialdehyde production during long-term recovery

open access: yes, 2000
The purpose of this study was to determine the effects of high intensity eccentric muscle damage on plasma creatine kinase and plasma malondialdehyde. Twelve subjects, who served as their own control, performed 10 sets of eccentric knee extensions at a ...
Wilson, Stephen J.
core  

Malondialdehyde and proline content.

open access: yes, 2013
Malondialdehyde (MDA) (nmol g−1 FW) and proline content in plants (µmol g−1 FW) exposed to different soils collected in Ervedosa mine area and to REF and OECD artificial soil.
Sara C. Antunes (397106)   +6 more
core   +1 more source

Serum Ischemia-Modified Albumin and Malondialdehyde Levels and Superoxide Dismutase Activity in Patients with Fibromyalgia [PDF]

open access: yes, 2014
Background: The aim of the study was to determine serum ischemia modified albumin and malondialdehyde levels as markers of oxidative stress and serum superoxide dismutase activity as a marker of antioxidant defense and their associations with clinical ...
Cicekler, Humeyra   +3 more
core   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu   +10 more
wiley   +1 more source

Study of Lipid peroxidation Marker (MDA) and Vitamin C in Pregnancy-Induced Hypertension [PDF]

open access: yesJournal of Sharif Medical & Dental College, 2018
Objective: To determine the levels of malondialdehyde (MDA) and vitamin C in hypertensive pregnant women as compared to normotensive pregnant women and non-pregnant control subjects.
Ghazal Mansoor   +5 more
doaj  

Acupuncture inhibits Notch1 and Hes1 protein expression in the basal ganglia of rats with cerebral hemorrhage

open access: yesNeural Regeneration Research, 2015
Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the
Wei Zou   +6 more
doaj   +1 more source

Oxidative Stress and Trace Elements in Patients with Non-Diabetic Hemodialysis [PDF]

open access: yes
Several evidences show that oxidative stress is high among patients with hemodialysis. This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis.
امانی, مجتبی   +7 more
core  

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia   +8 more
wiley   +1 more source

The Curative Activity of Isolated Fraction from Spathodea campanulata Beauv Stem Bark on Rat’s Exposed to Benzopyrene

open access: yesJournal of Tropical Life Science, 2014
This paper reports a screening results of the secondary metabolites composed in Spathodea campanulata Beauv stem bark, evaluate inhibiting activity of malondialdehyde (MDA) on rat’s cancer model exposed with benzopyrene, and ...
Masruri Masruri   +4 more
doaj  

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