Results 1 to 10 of about 219 (97)
Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis [PDF]
Viruses, 2010 Mouse mammary tumor virus (MMTV), which was discovered as a milk‑transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer. Like other complex retroviruses, MMTV encodes a number of accessory proteins that both facilitate infection and affect host immune response ...
Susan R. Ross
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Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice
Current Issues in Molecular Biology, 2023 Among genetically engineered mouse models of breast cancer, MMTV-PyVT is a mouse strain in which the oncogenic polyoma virus middle T antigen is driven by the mouse mammary tumor virus promoter. The aim of the present study was to perform morphologic and
Chien-Liang Liu +6 more
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Special Issue “Human Betaretrovirus and Related Diseases”
Viruses, 2022 A betaretrovirus resembling mouse mammary tumor virus (MMTV) was first linked with human breast cancer over 50 years ago [...]
Andrew L. Mason
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Merlin deficiency alters the redox management program in breast cancer
Molecular Oncology, 2021 The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues.
Mateus Mota +6 more
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Viruses, 2023 Mouse mammary tumor virus (MMTV) is a betaretrovirus that causes breast cancer in mice. The mouse mammary epithelial cells are the most permissive cells for MMTV, expressing the highest levels of virus upon infection and being the ones later transformed ...
Waqar Ahmad +7 more
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Cryoelectron Microscopy of Mouse Mammary Tumor Virus [PDF]
Journal of Virology, 2004 ABSTRACT Cryoelectron microscopy of Mouse mammary tumor virus , a Betaretrovirus , provided information about glycoprotein structure and core formation. The virions showed the broad range of diameters typical of retroviruses.
Briggs, J. +3 more
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Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype. [PDF]
PLoS ONE, 2014 Mammary epithelial (ME) cells cultured under conventional conditions senesce after several passages. Here, we demonstrate that mouse ME cells isolated from normal mammary glands or from mouse mammary tumor virus (MMTV)-Neu-induced mammary tumors, can be ...
Francisco R Saenz +10 more
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Viruses, 2022 A Human Betaretrovirus (HBRV) has been identified in humans, dating as far back as about 4500 years ago, with a high probability of it being acquired by our species around 10,000 years ago, following a species jump from mice to humans.
Generoso Bevilacqua
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Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. [PDF]
PLoS ONE, 2012 We have generated a new and improved transgenic mouse strain that permits a temporally controlled expression of transgenes throughout mammary gland development.
Kazuhito Sakamoto +2 more
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Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue
Viruses, 2022 Since its discovery as a milk factor, mouse mammary tumor virus (MMTV) has been shown to cause mammary carcinoma and lymphoma in mice. MMTV infection depends upon a viral superantigen (sag)-induced immune response and exploits the immune system to ...
Francesca Parisi +4 more
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