Results 11 to 20 of about 60,982 (185)

Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect [PDF]

BMC Biology
Background Tumor-associated architecture and emerging mechanical properties (forces, pressure, tension, stiffness) affect the growth and invasiveness of cancer cells.
Lisbeth Berrueta, Chandra Bhan, Yi He, Rebecca D. Thompson, Oscar Safairad, Andrew D. Doyle, Paola Pérez, Daniel Martin, Mazen Mezher, Alexander Cartagena-Rivera, Gary J. Badger, Helene M. Langevin   +11 more
doaj   +2 more sources

Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine [PDF]

Frontiers in Immunology
IntroductionOncolytic vaccinia virus (VACV) strains are being investigated for use in immunotherapy as a new experimental cancer treatment. Here, we describe the construction, characterization, and use of VACV strains co-expressing murine Interleukin 2 ...
Mingyu Ye, Ivan Petrov, Ivaylo Gentschev, Eman M. Othman, Aladar A. Szalay, Aladar A. Szalay, Aladar A. Szalay   +6 more
doaj   +2 more sources

Human betaretrovirus (HBRV), homologous to mouse mammary tumor virus (MMTV), and human breast cancer: a significant epidemiological association [PDF]

Retrovirology
Background Breast cancer is the most commonly diagnosed cancer globally. The potential role of oncogenic viruses, particularly Human Betaretrovirus (HBRV, formerly MMTV-LV/HMTV), in the pathogenesis of breast cancer has been a subject of research for ...
Fateme Saeedi-Moghaddam, Nazila Saffarian, Sayed-Hamidreza Mozhgani   +2 more
doaj   +2 more sources

Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon-β pathways [PDF]

Biomolecules & Biomedicine
Decitabine (DAC), a DNA methyltransferase inhibitor (DNMTi), is clinically effective in hematological malignancies such as myelodysplastic syndrome and acute myeloid leukemia, but its precise antineoplastic mechanisms remain incompletely understood ...
Ryan Johnson, Andrew Brola, Cade Wycoff, William Wycoff, Seth Neumeyer, Richard Tuttle, Sarah Light, Jiayi Li, Stephen Christensen, Yingguang Liu   +9 more
doaj   +2 more sources

IFI16/IFI202 blockade suppresses tumor growth through CD8+ T-cell–mediated immunity [PDF]

Breast Cancer Research
Background Tumor-associated macrophages (TAMs) are key drivers of immunosuppressive inflammation in the breast cancer microenvironment, promoting tumor progression and resistance to immune checkpoint blockade.
Ga Young Lim, Na-Lee Ka, Seung-Su Kim, Mi-Ock Lee   +3 more
doaj   +2 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Association of Mouse Mammary Tumor Virus With Human Breast Cancer: Histology, Immunohistochemistry and Polymerase Chain Reaction Analyses

Frontiers in Oncology, 2018
PurposeThe purpose of this study is to determine whether mouse mammary tumor virus (MMTV)-associated human breast cancer has the same or similar histology to MMTV-associated mouse mammary tumors.
James S. Lawson, Chiara Mazzanti, Prospero Civita, Michele Menicagli, Christopher C. Ngan, Noel J. Whitaker, Jacob Hochman, Ori Braitbard, Benafsha Yosufi, Wendy K. Glenn   +9 more
doaj   +1 more source

Multi-color Flow Cytometry for Comprehensive Analysis of the Tumor Immune Infiltrate in a Murine Model of Breast Cancer

Bio-Protocol, 2021
Flow cytometry is a popular laser-based technology that allows the phenotypic and functional characterization of individual cells in a high-throughput manner.
Ana Almeida, Miriam Fein, Mikala Egeblad
doaj   +1 more source

Mouse Mammary Tumor Virus Infects Human Cells [PDF]

Cancer Research, 2005
Abstract Mouse mammary tumor virus (MMTV) has long been speculated to be involved in human breast cancer and more recently in human primary biliary cirrhosis. Despite complete proviral sequences markedly homologous to MMTV being identified in human breast cancer tissue, no convincing evidence has been presented to date that MMTV can ...
Stanislav, Indik, Walter H, Günzburg, Brian, Salmons, Francoise, Rouault   +3 more
openaire   +2 more sources

Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar

Infectious Agents and Cancer, 2017
Background Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors.
Thar Htet San, Masayoshi Fujisawa, Soichiro Fushimi, Teizo Yoshimura, Toshiaki Ohara, Lamin Soe, Ngu Wah Min, Ohnmar Kyaw, Xu Yang, Akihiro Matsukawa   +9 more
doaj   +1 more source