Results 21 to 30 of about 60,982 (185)
Rapid spread of mouse mammary tumor virus in cultured human breast cells
Retrovirology, 2007 Background The role of mouse mammary tumor virus (MMTV) as a causative agent in human breast carcinogenesis has recently been the subject of renewed interest.
Günzburg Walter H +4 more
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Amplification of mouse mammary tumor virus genomes in non-mammary tumor cells [PDF]
Journal of Virology, 1989 Extra proviral copies of mouse mammary tumor virus (MMTV) are known to be present in the genomes of certain T-cell lymphomas of mice. Analysis of additional non-mammary tumor cell types known to express MMTV transcripts and antigens revealed the presence of extra acquired MMTV proviruses in a pituitary tumor cell line, a macrophage line, and Leydig ...
J, Racevskis, H, Beyer
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Apc mutation enhances PyMT-induced mammary tumorigenesis.
PLoS ONE, 2011 The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation ...
Jenifer R Prosperi +3 more
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Cells, 2013 Tumorigenesis is often described as a result of accumulated mutations that lead to growth advantage and clonal expansion of mutated cells. There is evidence in the literature that cancer cells are influenced by the microenvironment.
Sonia M. Rosenfield, Gilbert H. Smith
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Mouse Mammary Tumor Virus c-rel Transgenic Mice Develop Mammary Tumors [PDF]
Molecular and Cellular Biology, 2003 Amplification, overexpression, or rearrangement of the c-rel gene, encoding the c-Rel NF-kappaB subunit, has been reported in solid and hematopoietic malignancies. For example, many primary human breast cancer tissue samples express high levels of nuclear c-Rel. While the Rev-T oncogene v-rel causes tumors in birds, the ability of c-Rel to transform in
Raphaëlle, Romieu-Mourez +7 more
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Intestinal Immune System and Amplification of Mouse Mammary Tumor Virus
Frontiers in Cellular and Infection Microbiology, 2022 Mouse mammary tumor virus (MMTV) is a virus that induces breast cancer in mice. During lactation, MMTV can transmit from mother to offspring through milk, and Peyer’s patches (PPs) in mouse intestine are the first and specific target organ.
Lankai Chen +6 more
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Effect of trypsin on mouse mammary tumor virus [PDF]
Journal of Virology, 1976 Undisrupted mouse mammary tumor virus (MuMTV) derived from the milk of of RIII mice has been analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electron microscopy after treatment with insolubilized trypsin. No alterations were found in viral fine structure by either freeze-etch or negative-stain electron microscopy.
Sheffield, J B +3 more
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Infectious Agents and Cancer, 2017 Background Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast cancer. Here we demonstrate that these
James S. Lawson, Wendy K. Glenn
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Breast Cancer: Basic and Clinical Research, 2020 Background: Viral cause of sporadic breast cancer (SBC) has been suggested based on the experimental murine model of mammary tumor caused by mouse mammary tumor virus (MMTV), Epstein-Barr virus (EBV), and human papillomavirus (HPV).
Mohammad Al Hamad +9 more
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A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]
PLoS ONE, 2017 This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc +5 more
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