Results 71 to 80 of about 89,044 (334)
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
A Keratin Peptide Inhibits Mannose-Binding Lectin [PDF]
The Journal of Immunology, 2001 Abstract Complement plays a significant role in mediating endothelial injury following oxidative stress. We have previously demonstrated that the lectin complement pathway (LCP), which is initiated by deposition of the mannose-binding lectin (MBL), is largely responsible for activating complement on endothelial cells following periods of
Gregory L. Stahl +7 more
openaire +3 more sources
Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim +9 more
wiley +1 more source
Microbiome Single Cell Atlases Generated with a Commercial Instrument
Advanced Science, EarlyView.Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li +8 more
wiley +1 more source
Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity
Advanced Science, EarlyView.Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi +10 more
wiley +1 more source
A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2 [PDF]
, 2015 Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the ...
Drickamer, K +5 more
core +1 more source
Journal of Biological Chemistry, 2013 Background: The exact staphylococcal antigenic determinants of anti-staphylococcal IgG and mannose-binding lectin (MBL) have not been determined. Results: The antigenic epitopes of the staphylococcal wall teichoic acid (WTA) for serum IgG and MBL are O-N-
K. Kurokawa +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.Upregulated glycosyltransferase GALNT9 in neuroendocrine (NE) carcinomas increases O‐GalNAc glycosylation on cell membrane proteins, particularly Annexin‐A2 (ANXA2). Elevated O‐GalNAc glycan induces the binding of NE cancer cells to mannose binding lectin 2 (MBL2), activating the MBL‐MBL associated serine protease (MBL‐MASP) complement pathway in the ...
Xinyu Chen +24 more
wiley +1 more source
Biomolecules & Biomedicine, 2014 The aim of the study was to detect prevalence of MBL2 exon 1 (codons 52, 54 and 57) genetic polymorphism in postmenopausal women in Bosnia and Herzegovina and its possible role as genetic risk factor for susceptibility to occurrence of osteoporosis in ...
Emina Kiseljaković +7 more
doaj +1 more source
Towards defining the role of glycans as hardware in information storage and transfer: Basic principles, experimental approaches and recent progress [PDF]
, 2001 The term `code' in biological information transfer appears to be tightly and hitherto exclusively connected with the genetic code based on nucleotides and translated into functional activities via proteins.
Gabius, Hans-Joachim +6 more
core +1 more source