Results 81 to 90 of about 41,940 (203)

Sequence‐Based and Functional Analysis for the Discovery of N‐Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This research offers valuable understanding of how N‐glycans are broken down by the gut microbiota of infants, focusing on glycoside hydrolase families GH2, GH20, and GH18. It reveals that the gut microbiota of breastfed infants has a diverse array of genes coding for these enzymes.
Irene Boscá‐Sánchez, Jesús Rodríguez‐Díaz, María J. Yebra   +2 more
wiley   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

Interactions of Mucus Monosaccharides and the Epidermal Microbiome in Four Benthic Elasmobranchs

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Here we collected mucus and microbes from the skin of Elasmobranchs to identify interactions between mucus and the microbial community. We identified key microbial genes involved in the metabolism of mucus carbohydrates in Elasmobranchs. ABSTRACT Epidermal mucus is a complicated mixture of macromolecules which acts as the first line of defence for ...
Emma N. Kerr, Long Yu, Ryan D. Hesse, Chloe N. Roberts, Vincent Bulone, Lauren Meyer, Robert A. Edwards, Michael P. Doane, Elizabeth A. Dinsdale   +8 more
wiley   +1 more source

The clinical relevance of MBL2 gene polymorphism and sepsis

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To detect the clinical relevance of mannose-binding lectin 2 (MBL2) gene polymorphism and sepsis in Chinese lived in Hainan island. Methods: Blood samples from 57 patients with sepsis and 69 patients without sepsis were collected in the ICU of
Shao-Wen Cheng, Li-Na Xian, Zhi-Xing Lin, Xue Ao, Jun-Yi Yao, Ying-Qing Li, Yong-Yan Li, Xiu-Ru Li, Wei-Cheng Wang, Chuan-Zhu Lyu, Ying Li   +10 more
doaj   +1 more source

Mannose binding lectin polymorphisms in systemic lupus erythematosus in Spain

European Journal of Inflammation, 2016
Low mannose binding lectin (MBL) producer genotypes have been considered as a systemic lupus erythematosus (SLE) risk factor. The aim of this study was to explore whether polymorphisms in the MBL gene are associated with susceptibility to SLE and disease-
Inés Losada López, Mercedes García Gasalla, Juan González Moreno, Araceli Serrano, Francisco Javier Domínguez Valdés, Joan Milà, Antoni Payeras   +6 more
doaj   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, Volume 13, Issue 16, 18 March 2026.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Neutron Crystallography Study of Host–Pathogen Recognition Enhanced by Hydrogen/Deuterium Exchange on Carbohydrates

ChemistryEurope, Volume 4, Issue 3, March 2026.
Neutron macromolecular crystallography enabled by deuteration of biomolecules reveals how the opportunistic pathogen Pseudomonas aeruginosa utilizes calcium‐dependent lectin for binding to human sugars. Neutron diffraction on the complex highlights hydrogen bond network, protonation of amino acids and role of calcium ion.
Theodore Arnaud, Chloé Tatol, Juliette M. Devos, Lukas Gajdos, Sébastien Vidal, Marek Korsak, Annabelle Varrot, Michaela Wimmerova, Sophie Feuillastre, Matthew P. Blakeley, Anne Imberty   +10 more
wiley   +1 more source

Mannose-binding lectin deficiency and miscarriages in rheumatoid arthritis

Autoimmunity, 2017
Objective: To investigate the association between mannose-binding lectin (MBL) serum level and MBL2 polymorphisms, and the frequency of spontaneous miscarriages in rheumatoid arthritis (RA) patients.
Juliana Z. Cieslinski, Isabela Goeldner, Thelma l. Skare, Renato Nisihara, Fabiana A. De Andrade, Thirumalaisamy P. Velavan, Iara Messias-Reason, Shirley R. R. Utiyama   +7 more
doaj   +1 more source