Results 81 to 90 of about 89,044 (334)

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

Cancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang, Chen Zhang, Ruichen Zang, Weiwu Chen, Yining Guo, Haofei Jiang, Jing Le, Kunyu Wang, Haobo Fan, Xudong Wang, Sisi Mo, Peng Gao, Wenhao Guo, Xinrong Jiang, Fengbin Gao, Junming Jiang, Juyan Zheng, Yuxing Chen, Yicheng Chen, Yanlan Yu, Guoqing Ding   +20 more
wiley   +1 more source

Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]

, 2010
At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick, Lasanajak, Yi, Proost, Paul, Rouge, Pierre, Schouppe, Dieter, Smith, David F, Van Damme, Els   +6 more
core   +2 more sources

Exploring the Impact of Phenanthroline‐Based Glycoconjugated Ru(II) Polypyridyl Photosensitizers on Metastasis‐Related Processes

Chemistry – A European Journal, EarlyView.
A novel family of water‐soluble, nontoxic, and phosphorescent N‐glycosylated Ru(II) phenanthroline‐based complexes are reported. They exhibit photoselectivity indexes ranging from 10 to 44 in PC‐3 cells, while impacting cell migration and resistance to detachment after irradiation with blue light.
Elena de la Torre‐Rubio, María‐Selma Arias‐Pérez, Lourdes Gude, Tomás Cuenca, Cristina García‐Iriepa, Eva Royo   +5 more
wiley   +1 more source

Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]

, 2019
The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B, Li, Qiongyu, Wong, Maurice, Xie, Yixuan   +3 more
core   +2 more sources

Glycans and Chirality: Stereoselectivity at the Core of DC‐SIGN's Recognition. A Novel View of the Optimum Minimal Ligand Epitope

Chemistry – A European Journal, EarlyView.
The stereochemical diversity of the “glycan code” enables similar chiral motifs to arise from both D‐ and L‐sugars. Focused on DC‐SIGN–glycan recognition, two diverse monosaccharide scaffolds, D‐Man (D‐Rha) and L‐Gal (L‐Fuc), maintain the exquisite stereochemistry encoded in the minimal binding epitope.
J. Daniel Martínez, Reyes Núñez‐Franco, Pablo Valverde, Sandra Delgado, Ana Ardá, Jesús Jiménez‐Barbero, Gonzalo Jiménez‐Oses, F. Javier Cañada   +7 more
wiley   +1 more source

Detection of Mannose Binding Lectin (MBL) -54 G/A Polymorphism in Preterm Labor in Hilla Province/Iraq

Journal of Pure and Applied Microbiology, 2018
To analyzes the association between Mannose binding lectin MBL gene and preterm labor, DNA was obtained from peripheral blood of 150 aborted women patients diagnosed as preterm labor and 150 healthy individual have no previous preterm history was ...
Lamees A. Abdul-Lateef, Ilham, A. Bunyan, Azal Alaa Al-Rubaeaee   +3 more
doaj   +1 more source

pH-Degradable mannosylated nanogels for dendritic cell targeting [PDF]

, 2016
We report on the design of glycosylated nanogels via core-cross linking of amphiphilic non-water-soluble block copolymers composed of an acetylated glycosylated block and a pentafluorophenyl (PFP) activated ester block prepared by reversible addition ...
Ayres, Neil, De Coen, Ruben, De Geest, Bruno, De Koker, Stefaan, Grooten, Johan, Louage, Benoit, Lybaert, Lien, Nuhn, Lutz, Risseeuw, Martijn, Taylor, Leeanne, Udhayakumar, Vimal Kumar, Van Calenbergh, Serge, Vanparijs, Nane   +12 more
core   +2 more sources

The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock

Mediators of Inflammation, 2013
Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest ...
G. De Pascale, S. Cutuli, M. Pennisi, M. Antonelli   +3 more
semanticscholar   +1 more source

Synthesis of Rhamnose‐Modified Lewis‐X‐Containing Saponins

European Journal of Organic Chemistry, EarlyView.
The synthesis of triterpenoid saponins bearing a Lewis‐X trisaccharide analogue, in which the fucose residue is replaced by a rhamnose, is presented. These saponins, designed as negative controls in dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing nonintegrin‐targeted therapeutic applications, are prepared through iterative and ...
Oscar Javier Gamboa Marin, Nitish Verma, Maude Cloutier, Charles Gauthier   +3 more
wiley   +1 more source

Oxidative stress decreases functional airway mannose binding lectin in COPD. [PDF]

PLoS ONE, 2014
We have previously established that a defect in the ability of alveolar macrophages (AM) to phagocytose apoptotic cells (efferocytosis) and pathogens is a potential therapeutic target in COPD. We further showed that levels of mannose binding lectin (MBL;
Hai B Tran, Jessica Ahern, Greg Hodge, Phillip Holt, Melinda M Dean, Paul N Reynolds, Sandra Hodge   +6 more
doaj   +1 more source