Results 31 to 40 of about 138,127 (342)

Engineering of GlcNAc-1-phosphotransferase for production of highly phosphorylated lysosomal enzymes for enzyme replacement therapy [PDF]

, 2017
Several lysosomal enzymes currently used for enzyme replacement therapy in patients with lysosomal storage diseases contain very low levels of mannose 6-phosphate, limiting their uptake via mannose 6-phosphate receptors on the surface of the deficient ...
Doray, Balraj, Kornfeld, Stuart, Lee, Wang-Sik, Liu, Lin   +3 more
core   +3 more sources

Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]

, 2018
The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć, Kamila Kozłowska, Marta Ząbczyńska   +2 more
core   +1 more source

Mannose Receptor 2 Attenuates Renal Fibrosis [PDF]

Journal of the American Society of Nephrology, 2012
Mannose receptor 2 (Mrc2) expresses an extracellular fibronectin type II domain that binds to and internalizes collagen, suggesting that it may play a role in modulating renal fibrosis. Here, we found that Mrc2 levels were very low in normal kidneys but subsets of interstitial myofibroblasts and macrophages upregulated Mrc2 after unilateral ureteral ...
Jesús M, López-Guisa, Xiaohe, Cai, Sarah J, Collins, Ikuyo, Yamaguchi, Daryl M, Okamura, Thomas H, Bugge, Clare M, Isacke, Claire L, Emson, Scott M, Turner, Stuart J, Shankland, Allison A, Eddy   +10 more
openaire   +2 more sources

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

PLoS Pathogens, 2008
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus ...
Sigrid E M Heinsbroek, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, Siamon Gordon   +5 more
doaj   +1 more source

Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery [PDF]

, 2015
Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling the efficacy of commercial vectors towards a variety of cell lines.
Benito, Juan M., Di Giorgio, Christophe, Díaz Moscoso, Alejandro, García Fernández, José Manuel, Méndez Ardoy, Alejandro, Ortiz Mellet, Carmen, Vierling, Pierre   +6 more
core   +1 more source

The Mannose Receptor in Regulation of Helminth-Mediated Host Immunity

Frontiers in Immunology, 2017
Infection with parasitic helminths affects humanity and animal welfare. Parasitic helminths have the capacity to modulate host immune responses to promote their survival in infected hosts, often for a long time leading to chronic infections.
Irma van Die, Richard D. Cummings
doaj   +1 more source

Transient Production of Human β-Glucocerebrosidase With Mannosidic-Type N-Glycan Structure in Glycoengineered Nicotiana benthamiana Plants

Frontiers in Plant Science, 2021
Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose
Naphatsamon Uthailak, Hiroyuki Kajiura, Hiroyuki Kajiura, Ryo Misaki, Ryo Misaki, Kazuhito Fujiyama, Kazuhito Fujiyama, Kazuhito Fujiyama   +7 more
doaj   +1 more source

A truncated lipoglycan from mycobacteria with altered immunological properties [PDF]

, 2010
Maintenance of cell-wall integrity in Mycobacterium tuberculosis is essential and is the target of several antitubercular drugs. For example, ethambutol targets arabinogalactan and lipoarabinomannan (LAM) biosynthesis through the inhibition of several ...
Alderwick, Luke J., Appelmelk, B. J., Besra, Gurdyal S, Bhatt, Apoorva, Birch, Helen, Eggeling, Lothar, Geurtsen, J, Maaskant, J, Nigou, Jerome, Singh, Albel   +9 more
core   +2 more sources

Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors [PDF]

Proceedings of the National Academy of Sciences, 2006
Enzyme replacement therapy (ERT) is available for several lysosomal storage diseases. Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).
William S, Sly, Carole, Vogler, Jeffrey H, Grubb, Beth, Levy, Nancy, Galvin, Yun, Tan, Tatsuo, Nishioka, Shunji, Tomatsu   +7 more
openaire   +2 more sources

Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. [PDF]

, 2006
Hepatic sinusoidal endothelial cells are unique among endothelial cells in their ability to internalize and process a diverse range of antigens. DC-SIGNR, a type 2 C-type lectin expressed on liver sinusoids, has been shown to bind with high affinity to ...
Adam Jennings, Alvarez, Appelmelk, Bartosch, Bashirova, Cormier, Cormier, Crispe, David H. Adams, Ebner, Engering, Feinberg, Flint, Gardner, Geijtenbeek, Grant, Guo, Halary, Hsu, Jameson, Jane A. McKeating, Jie Zhang, Klimstra, Knolle, Krutzik, Lalor, Lasala, Lee, Limmer, Lindenbach, Lindenbach, Lozach, Lozach, Lozach, Ludwig, Maeda, Marzi, McCully, Mitchell, Mukhtar, Patricia F. Lalor, Phoebe J. Sun, Pileri, Pohlmann, Pohlmann, Pohlmann, Pohlmann, Puig-Kroger, Relloso, Romani, Seternes, Simmons, Soilleux, Stefan Hubscher, Tassaneetrithep, Trumpfheller, Turville, Wai K. Lai, Wakita, Yang, Zhang, Zhong   +61 more
core   +2 more sources