Results 31 to 40 of about 84,098 (261)

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

eLife, 2020
HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary conservation of Vpr suggests an important yet poorly understood role for macrophages in HIV pathogenesis.
Jay Lubow, Maria C Virgilio, Madeline Merlino, David R Collins, Michael Mashiba, Brian G Peterson, Zana Lukic, Mark M Painter, Francisco Gomez-Rivera, Valeri Terry, Gretchen Zimmerman, Kathleen L Collins   +11 more
doaj   +1 more source

Glycoprotein Targeted CAR-NK Cells for the Treatment of SARS-CoV-2 Infection

Frontiers in Immunology, 2021
H84T-Banana Lectin (BanLec) CAR-NK cells bind high mannose glycosites that decorate the SARS-CoV-2 envelope, thereby decreasing cellular infection in a model of SARS-CoV-2. H84T-BanLec CAR-NK cells are innate effector cells, activated by virus.
Ilias Christodoulou, Ruyan Rahnama, Ruyan Rahnama, Jonas W. Ravich, Jaesung Seo, Sergey N. Zolov, Andrew N. Marple, Andrew N. Marple, David M. Markovitz, David M. Markovitz, Challice L. Bonifant, Challice L. Bonifant   +11 more
doaj   +1 more source

Mannose receptor regulates motility [PDF]

The Journal of Cell Biology, 2006
![Graphic][1] Myoblasts fail to fuse if they lack the mannose receptor (bottom). If myoblasts are to fuse with nascent myotubes and thus form muscles, they must apparently migrate and chew up extracellular matrix (ECM), according to Jansen and Pavlath (page [403][2 ...
openaire   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Mannose Receptor Ligands Regulate the Gene Expression of Toll-like Receptors in Chicken Monocytes

The Journal of Poultry Science, 2013
Pattern recognition receptors play an important role in distinguishing foreign organisms and triggering host defense responses. In this study, we present evidence for differential immune responses in chicken monocytes exposed to the mannose receptor (MR)
Li Yan, Zandong Li
doaj   +1 more source

Global transcriptional analysis of spontaneous sakacin P-resistant mutant strains of Listeria monocytogenes during growth on different sugars. [PDF]

PLoS ONE, 2011
Subclass IIa bacteriocins have strong antilisterial activity and can control the growth of Listeria monocytogenes in food. However, L. monocytogenes may develop resistance towards such bacteriocins.
Girum Tadesse Tessema, Trond Møretrø, Lars Snipen, Lars Axelsson, Kristine Naterstad   +4 more
doaj   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Soluble C-Type Lectin-Receptor Ligands Stimulate ROS Production in Dendritic Cells and Potentiate Killing of MRSA as Well as the MRSA Induced IL-12 Production

Frontiers in Immunology, 2022
Methicillin resistant Staphylococcus aureus (MRSA) has developed resistance to most β-lactam antibiotics leaving few treatment options against infections with MRSA.
Helene M. S. Eld, Peter R. Johnsen, Emilie M. Nielsen, Frederikke Z. Jørgensen, Marie Lindstrøm-Svendsen, Mara Baldry, Hanne Ingmer, Hanne Frøkiær   +7 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1

Cell Reports, 2017
Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are unknown.
Murugesan V.S. Rajaram, Eusondia Arnett, Abul K. Azad, Evelyn Guirado, Bin Ni, Abigail D. Gerberick, Li-Zhen He, Tibor Keler, Lawrence J. Thomas, William P. Lafuse, Larry S. Schlesinger   +10 more
doaj   +1 more source