Results 31 to 40 of about 2,400,964 (279)

Macrophage-Targeted Punicalagin Nanoengineering to Alleviate Methotrexate-Induced Neutropenia: A Molecular Docking, DFT, and MD Simulation Analysis

Molecules, 2022
Punicalagin is the most bioactive pomegranate polyphenol with high antioxidant and free-radical scavenging activity and can potentially cure different ailments related to the cardiovascular system.
Ritu Karwasra, Shaban Ahmad, Nagmi Bano, Sahar Qazi, Khalid Raza, Surender Singh, Saurabh Varma   +6 more
doaj   +1 more source

Mannosylation of virus-like particles enhances internalization by antigen presenting cells. [PDF]

PLoS ONE, 2014
Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses.
Farah Al-Barwani, Sarah L Young, Margaret A Baird, David S Larsen, Vernon K Ward   +4 more
doaj   +1 more source

Structural Model for the Mannose Receptor Family Uncovered by Electron Microscopy of Endo180 and the Mannose Receptor [PDF]

Journal of Biological Chemistry, 2006
The mannose receptor family comprises four members in mammals, Endo180 (CD280), DEC-205 (CD205), phospholipase A(2) receptor (PLA(2)R) and the mannose receptor (MR, CD206), whose extracellular portion contains a similar domain arrangement: an N-terminal cysteine-rich domain (CysR) followed by a single fibronectin type II domain (FNII) and 8-10 C-type ...
Boskovic, Jasminka, Arnold, James N., Stilion, Richard, Gordon, Siamon, Sim, Robert B., Rivera-Calzada, Angel, Wienke, Dirk, Isacke, Clare M., Martínez-Pomares, Luisa, Llorca, Óscar   +9 more
openaire   +4 more sources

Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors [PDF]

Proceedings of the National Academy of Sciences, 2006
Enzyme replacement therapy (ERT) is available for several lysosomal storage diseases. Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).
Shunji Tomatsu, Carole Vogler, William S. Sly, Yun Tan, Beth Levy, Tatsuo Nishioka, Nancy Galvin, Jeffrey H. Grubb   +7 more
openaire   +3 more sources

An Extended Conformation of the Macrophage Mannose Receptor [PDF]

Journal of Biological Chemistry, 2001
The macrophage mannose receptor mediates phagocytosis of pathogenic microorganisms and endocytosis of potentially harmful soluble glycoproteins by recognition of their defining carbohydrate structures. The mannose receptor is the prototype for a family of receptors each having an extracellular region consisting of 8-10 domains related to C-type ...
Catherine E. Napper, Maureen E. Taylor, Mark H. Dyson   +2 more
openaire   +3 more sources

The mannose receptor mediates dengue virus infection of macrophages. [PDF]

PLoS Pathogens, 2008
Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans. To our knowledge, we show for the first time that the MØ mannose receptor (MR) binds
Joanna L Miller, Barend J M de Wet, Luisa Martinez-Pomares, Catherine M Radcliffe, Raymond A Dwek, Pauline M Rudd, Siamon Gordon   +6 more
doaj   +1 more source

pH-Degradable mannosylated nanogels for dendritic cell targeting [PDF]

, 2016
We report on the design of glycosylated nanogels via core-cross linking of amphiphilic non-water-soluble block copolymers composed of an acetylated glycosylated block and a pentafluorophenyl (PFP) activated ester block prepared by reversible addition ...
Ayres, Neil, De Coen, Ruben, De Geest, Bruno, De Koker, Stefaan, Grooten, Johan, Louage, Benoit, Lybaert, Lien, Nuhn, Lutz, Risseeuw, Martijn, Taylor, Leeanne, Udhayakumar, Vimal Kumar, Van Calenbergh, Serge, Vanparijs, Nane   +12 more
core   +2 more sources

Convergent and divergent mechanisms of sugar recognition across kingdoms [PDF]

, 2014
Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features ...
Drickamer, K, Taylor, ME
core   +1 more source

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Kolle, S., Plendl, J., Sinowatz, Fred
core   +1 more source

Binding Properties of the Mannose Receptor

Immunobiology, 2001
A comprehensive approach to the study of mannose receptor (MR) biology has unveiled an unexpected level of complexity and stresses the importance of post-translational modifications and gene regulation in the analysis of protein function. The existence of endogenous tissue ligands for the MR highlights the need to reduce MR expression in antigen ...
Siamon Gordon, Luisa Martinez-Pomares, Philip R. Taylor, Sheena A. Linehan   +3 more
openaire   +3 more sources