Results 51 to 60 of about 2,479,436 (371)

Pneumolysin binds to the Mannose-Receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

Nature Microbiology, 2018
Streptococcus pneumoniae (the pneumococcus) is a major cause of mortality and morbidity globally, and the leading cause of death in children under 5 years old.
K. Subramanian, D. R. Neill, H. Malak, Laura Spelmink, Shadia Khandaker, G. Dalla Libera Marchiori, Emma Dearing, A. Kirby, Marie Yang, A. Achour, J. Nilvebrant, P. Nygren, Laura Plant, A. Kadioglu, B. Henriques‐Normark   +14 more
semanticscholar   +1 more source

Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. [PDF]

, 2006
Hepatic sinusoidal endothelial cells are unique among endothelial cells in their ability to internalize and process a diverse range of antigens. DC-SIGNR, a type 2 C-type lectin expressed on liver sinusoids, has been shown to bind with high affinity to ...
Adam Jennings, Alvarez, Appelmelk, Bartosch, Bashirova, Cormier, Cormier, Crispe, David H. Adams, Ebner, Engering, Feinberg, Flint, Gardner, Geijtenbeek, Grant, Guo, Halary, Hsu, Jameson, Jane A. McKeating, Jie Zhang, Klimstra, Knolle, Krutzik, Lalor, Lasala, Lee, Limmer, Lindenbach, Lindenbach, Lozach, Lozach, Lozach, Ludwig, Maeda, Marzi, McCully, Mitchell, Mukhtar, Patricia F. Lalor, Phoebe J. Sun, Pileri, Pohlmann, Pohlmann, Pohlmann, Pohlmann, Puig-Kroger, Relloso, Romani, Seternes, Simmons, Soilleux, Stefan Hubscher, Tassaneetrithep, Trumpfheller, Turville, Wai K. Lai, Wakita, Yang, Zhang, Zhong   +61 more
core   +2 more sources

Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]

, 2018
Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J, Lebrilla, Carlito B, Li, Qiongyu, McDonald, Karen A, Nandi, Somen, Xiong, Yongao   +5 more
core   +3 more sources

Mannose-functionalization of reconstituted high-density lipoprotein nanoparticles improves payload delivery and enhances M2-to-M1 phenotype reprogramming of RAW 264.7 macrophages polarized by B16-F10 melanoma cells

Frontiers in Drug Delivery, 2023
The targeting and conversion of the immunosuppressive (M2) tumor-associated macrophages (TAMs) to an immunostimulatory (M1) phenotype can induce tumor regression in advanced melanoma.
Akpedje S. Dossou, Morgan E. Mantsch, Nirupama Sabnis, Rance E. Berg, Rafal Fudala, Andras G. Lacko   +5 more
doaj   +1 more source

Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells

Molecules, 2020
Recently, gold nanoparticles (Au NPs) have been used to study the treatment of malignant tumors due to their higher biocompatibility and lesser toxicity.
Han-Chen Lin, Keng-Fang Hsu, Chiao-Ling Lai, Tzu-Chien Wu, Hui-Fen Chen, Chian-Hui Lai   +5 more
doaj   +1 more source

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D., Buttini, Francesca, Cavaco, Joana S., Grenha, Ana, Guerreiro, Filipa, Pontes, Jorge Filipe, Rodrigues, Susana, Rosa Da Costa, Ana   +7 more
core   +1 more source

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance PD-L1 is well known as an immune checkpoint molecule, which suppresses immune surveillance through binding to its receptor PD-1. Intracellular PD-L1 can also protect messenger RNAs of several DNA damage repair–related genes from degradation ...
Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun-Min Chen, Q. Lei, Song Zhang, Yanping Xu, Lei Lv   +12 more
semanticscholar   +1 more source

Experimental Trichinellosis in rats: Peritoneal macrophage activity [PDF]

Archives of Biological Sciences, 2010
The influence of Trichinella spiralis infection on macrophage activity in rats during the first 28 days of infection was examined by measuring the production of NO and IL-6, as well as the expression of mannose receptor on the surface of peritoneal ...
Gruden-Movsesijan Alisa, Sofronić-Milosavljević Ljiljana   +1 more
doaj   +1 more source

Glycoprotein Targeted CAR-NK Cells for the Treatment of SARS-CoV-2 Infection

Frontiers in Immunology, 2021
H84T-Banana Lectin (BanLec) CAR-NK cells bind high mannose glycosites that decorate the SARS-CoV-2 envelope, thereby decreasing cellular infection in a model of SARS-CoV-2. H84T-BanLec CAR-NK cells are innate effector cells, activated by virus.
Ilias Christodoulou, Ruyan Rahnama, Ruyan Rahnama, Jonas W. Ravich, Jaesung Seo, Sergey N. Zolov, Andrew N. Marple, Andrew N. Marple, David M. Markovitz, David M. Markovitz, Challice L. Bonifant, Challice L. Bonifant   +11 more
doaj   +1 more source

Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers [PDF]

, 2019
© The Royal Society of Chemistry 2019.Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications.
Fernandez-Trillo, F., Foralosso, R., He, Y., King, P.J.S., Laughton, C. A., Madeira do O, J., Mantovani, G., Mastrotto, F., Stolnik, S., Styliari, Ioanna Danai, van der Walle, C.F., Xerri, R.M., Yilmaz, G.   +12 more
core   +4 more sources