Results 51 to 60 of about 288,019 (165)

Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells

Journal of Neuroinflammation, 2010
Background Interleukin (IL)-6 plays a pivotal role in a variety of CNS functions such as the induction and modulation of reactive astrogliosis, pathological inflammatory responses and neuroprotection.
Dohi Shuji, Iida Hiroki, Yamaguchi Shinobu, Matsushima-Nishiwaki Rie, Tanabe Kumiko, Kozawa Osamu   +5 more
doaj   +1 more source

Activation of ERK1/2 MAP kinases in Familial Amyloidotic Polyneuropathy [PDF]

Journal of Neurochemistry, 2006
AbstractFamilial amyloidotic polyneuropathy (FAP) is a neurodegenerative disorder characterized by the extracellular deposition of transthyretin (TTR), especially in the PNS. Given the invasiveness of nerve biopsy, salivary glands (SG) from FAP patients were used previously in microarray analysis; mitogen‐activated protein (MAP) kinase phosphatase 1 ...
F A, Monteiro, M M, Sousa, I, Cardoso, J Barbas, do Amaral, A, Guimarães, M J, Saraiva   +5 more
openaire   +2 more sources

The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

Cancer Biology & Therapy
Thyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the ...
Hannah M. Hicks, Veronica L. Nassar, Jane Lund, Madison M. Rose, Rebecca E. Schweppe   +4 more
doaj   +1 more source

Exploitation of Host Epithelial Signaling Networks by Respiratory Bacterial Pathogens

Journal of Pharmacological Sciences, 2003
Although tremendous effort has been put towards identifying the surface molecules of nontypeable Haemophilus influenzae (NTHi) for vaccine development over the past decades, it is only recently that we have begun to appreciate the intricate host ...
Jian-Dong Li
doaj   +1 more source

Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells

Journal of Pharmacological Sciences, 2009
Many epidemiologic studies have reported that dietary flavonoids provide protection against cardiovascular disease. Quercetin, a member of the bioflavonoids family, has been proposed to have anti-inflammatory, anti-atherogenic, and anti-hypertensive ...
Keisuke Ishizawa, Yuki Izawa-Ishizawa, Sachiyo Ohnishi, Yuki Motobayashi, Kazuyoshi Kawazoe, Shuichi Hamano, Koichiro Tsuchiya, Shuhei Tomita, Kazuo Minakuchi, Toshiaki Tamaki   +9 more
doaj   +1 more source

Cardiotrophin-1 induces matrix metalloproteinase-1 in human aortic endothelial cells. [PDF]

PLoS ONE, 2013
Rupture of an atherosclerotic plaque is a key event in the development of cardiovascular disorders, in which matrix metalloproteinase-1 (MMP-1) plays a crucial role by degradation of extracellular matrix resulting in plaque instability.
Akinori Tokito, Michihisa Jougasaki, Tomoko Ichiki, Shuichi Hamasaki   +3 more
doaj   +1 more source

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development [PDF]

Proceedings of the National Academy of Sciences, 2010
MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. However, Mnk1/2 double knockout (Mnk-DKO) mice show normal cell growth and development despite an absence of eIF4E ...
Takeshi, Ueda, Masato, Sasaki, Andrew J, Elia, Iok In Christine, Chio, Koichi, Hamada, Rikiro, Fukunaga, Tak W, Mak   +6 more
openaire   +2 more sources

ERK1/2 MAP kinases: Structure, function, and regulation

Pharmacological Research, 2012
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription.
openaire   +2 more sources

The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response [PDF]

Cellular Microbiology, 2010
Infection with Shiga toxin (STx)-producing bacteria can progress to a toxemic, extraintestinal injury cascade known as haemolytic uremic syndrome (HUS), the leading cause of acute renal failure in children. Mounting evidence suggests that STx activates stress response pathways in susceptible cells and has implicated the p38 mitogen-activated protein ...
Jose B, Saenz, Jinmei, Li, David B, Haslam   +2 more
openaire   +2 more sources

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

The EMBO journal, 1996
The Tpl-2 protein serine/threonine kinase was originally identified, in a C-terminally deleted form, as the product of an oncogene associated with the progression of Moloney murine leukemia virus-induced T cell lymphomas in rats. The kinase domain of Tpl-2 is homologous to the Saccharomyces cerevisiae gene product, STE11, which encodes a MAP kinase ...
A, Salmeron, T B, Ahmad, G W, Carlile, D, Pappin, R P, Narsimhan, S C, Ley   +5 more
openaire   +3 more sources