Results 31 to 40 of about 288,019 (165)

Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt

Cellular Physiology and Biochemistry, 2017
Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study, we investigated the mechanism behind the epidermal growth factor (EGF)-induced ...
Tetsu Kawabata, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka   +7 more
doaj   +1 more source

Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension

Biomolecules & Biomedicine, 2011
Endothelin 1 (ET-1) is vasoactive peptide that acts via ET-A receptors coupling inducing vascular smooth muscle cell proliferation and contraction. ET-1 is involved in the development and maintenance of hypertension.
Farid Ljuca, Gorazd Drevenšek, Enver Zerem   +2 more
doaj   +1 more source

The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis [PDF]

Nephrology Dialysis Transplantation, 2007
In vitro, the extracellular signal-regulated kinase (ERK) is an intracellular convergence point of multiple stimuli, which affect the cell cycle. However, the role of ERK in cell cycle regulation in vivo is unknown.To address this issue, ERK activity was blocked both in vitro in mesangial cells (MC) and in vivo in experimental glomerulonephritis (GN ...
Dirk, Bokemeyer, Darius, Panek, Masashi, Kitahara, James M, Trzaskos, Christa E, Müller, Jörg, Hockemeyer, Uta, Kunter, Peter, Boor, Jürgen, Floege, Herbert J, Kramer, Tammo, Ostendorf   +10 more
openaire   +2 more sources

The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis

eLife, 2016
Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood.
Saravanapriah Nadarajan, Firaz Mohideen, Yonatan B Tzur, Nuria Ferrandiz, Oliver Crawley, Alex Montoya, Peter Faull, Ambrosius P Snijders, Pedro R Cutillas, Ashwini Jambhekar, Michael D Blower, Enrique Martinez-Perez, J Wade Harper, Monica P Colaiacovo   +13 more
doaj   +1 more source

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages

Journal of Inflammation, 2006
Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
doaj   +1 more source

Staphylococcal PknB as the first prokaryotic representative of the proline-directed kinases. [PDF]

PLoS ONE, 2010
In eukaryotic cell types, virtually all cellular processes are under control of proline-directed kinases and especially MAP kinases. Serine/threonine kinases in general were originally considered as a eukaryote-specific enzyme family.
Malgorzata Miller, Stefanie Donat, Sonja Rakette, Thilo Stehle, Thijs R H M Kouwen, Sander H Diks, Annette Dreisbach, Ewoud Reilman, Katrin Gronau, Dörte Becher, Maikel P Peppelenbosch, Jan Maarten van Dijl, Knut Ohlsen   +12 more
doaj   +1 more source

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Cellular & Molecular Biology Letters, 2022
Background Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis.
Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo, Guokun Wang   +8 more
doaj   +1 more source

MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension

American Journal of Physiology-Heart and Circulatory Physiology, 2013
Pulmonary hypertension (PH) results in pressure overload of the right ventricle (RV) of the heart, initiating pathological RV remodeling and ultimately leading to right heart failure. Substantial research indicates that signaling through the MAPK superfamily mediates pathological cardiac remodeling.
R Dale, Brown, S Kelly, Ambler, Min, Li, Timothy M, Sullivan, Lauren N, Henry, Joseph T, Crossno, Carlin S, Long, Timothy P, Garrington, Kurt R, Stenmark   +8 more
openaire   +4 more sources

Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning

Cell Reports, 2018
Summary: C. elegans vulval precursor cell (VPC) fates are patterned by an epidermal growth factor (EGF) gradient. High-dose EGF induces 1° VPC fate, and lower dose EGF contributes to 2° fate in support of LIN-12/Notch. We previously showed that the EGF 2°
Hanna Shin, Rebecca E.W. Kaplan, Tam Duong, Razan Fakieh, David J. Reiner   +4 more
doaj   +1 more source

Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor

Molecules, 2021
The purpose of this work is to investigate the protein kinase inhibitory activity of constituents from Acacia auriculiformis stem bark. Column chromatography and NMR spectroscopy were used to purify and characterize betulin from an ethyl acetate soluble ...
Augustine A. Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A. Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P. Petzer, Lesetja J. Legoabe, Stéphane Bach   +16 more
doaj   +1 more source