Results 11 to 20 of about 288,019 (165)

Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

Cellular Physiology and Biochemistry, 2015
Background/Aims: Evidence in multiple tissues, including retina, suggests generation of reactive oxygen species (ROS) and the ensuing oxidative stress as triggers for mitochondrial defects and cell apoptosis.
Rajakrishnan Veluthakal, Binit Kumar, Ghulam Mohammad, Anjaneyulu Kowluru, Renu A. Kowluru   +4 more
doaj   +1 more source

Trypanosoma brucei Lipophosphoglycan Activates Host Immune Responses via the TLR-mediated p38 MAP Kinase and NF-κB Pathways

Zoonoses, 2023
This study was aimed at investigating the immunoregulatory effects of trypanosomal lipophosphoglycan (LPG) anchored to trypanosome membranes, including the formation of neutrophil extracellular traps (NETs) and neutrophil cytokine release after parasite ...
Kai Zhang, Ning Jiang, Naiwen Zhang, Liying Yu, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen   +7 more
doaj   +1 more source

ERK1/2 MAP kinases in cell survival and apoptosis [PDF]

IUBMB Life, 2006
AbstractERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases.
Zhimin, Lu, Shuichan, Xu
openaire   +2 more sources

Reciprocal Regulation of Aquaporin-2 Abundance and Degradation by Protein Kinase A and p38-MAP Kinase [PDF]

Journal of the American Society of Nephrology, 2010
Arginine-vasopressin (AVP) modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water. AVP binds to vasopressin V2 receptors (V2R), increasing cAMP, which promotes the redistribution of AQP2 from intracellular vesicles into the plasma membrane.
NEDVETSKY PI, TABOR V, BEULSHAUSEN S, SKROBLIN P, KIRSCHNER A, MUTIG K, BOLTZEN M, PETRUCCI O, VOSSENKÄMPER A, WIESNER B, BACHMANN S, ROSENTHAL W, KLUSSMANN E., TAMMA, GRAZIA   +13 more
openaire   +3 more sources

PREDICTION OF 3D STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 USING ALPHAFOLD 2 AND SIMULATION OF ITS INTERACTION WITH MITOGEN-ACTIVATED PROTEIN KINASE 6 IN ARABIDOPSIS THALIANA [PDF]

Journal of Plant Development
Arabidopsis thaliana mitogen-activated protein kinase (MPK or MAPK) signaling network plays significant roles in various cellular processes. The three-dimensional structure of mitogen-activated protein kinase kinase 2 (MKK2), an upstream kinase in the ...
Sameer KHAN, Tim XING
doaj   +1 more source

Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts [PDF]

FEBS Letters, 1996
While much is known about the beneficial effects of myocardial stress adaptation, relatively less information is available about the adaptive mechanisms. To explore the signaling pathways of stress adaptation, isolated working rat hearts were divided into three groups.
Maulik, Nilanjana, Watanabe, Masazumi, Zu, You-Li, Huang, Chi-Kuang, Cordis, Gerald A., Schley, James A., Das, Dipak K.   +6 more
openaire   +2 more sources

Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells

Journal of Pharmacological Sciences, 2003
: The mechanism to enhance nerve growth factor (NGF, 2 ng/ml)-induced neurite outgrowth from PC12D cells by nardosinone isolated from Nardostachys chinensis was examined.
Ping Li, Tohru Yamakuni, Kimihiro Matsunaga, Shunzo Kondo, Yasushi Ohizumi   +4 more
doaj   +1 more source

Isopanduratin A Inhibits Tumor Necrosis Factor (TNF)-α-Induced Nuclear Factor κB Signaling Pathway by Promoting Extracellular Signal-Regulated Kinase-Dependent Ectodomain Shedding of TNF Receptor 1 in Human Lung Adenocarcinoma A549 Cells

BioChem, 2021
Tumor necrosis factor α (TNF-α) induces the nuclear factor κB (NF-κB) signaling pathway via TNF receptor 1 (TNF-R1). We recently reported that isopanduratin A inhibited the TNF-α-induced NF-κB signaling pathway in human lung adenocarcinoma A549 cells. In
Chihiro Moriwaki, Riho Tanigaki, Yasunobu Miyake, Nghia Trong Vo, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Truong Nhat Van Do, Hai Xuan Nguyen, Takao Kataoka   +8 more
doaj   +1 more source

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen‐activated protein (MAP) kinase and MAP‐kinase‐activated kinases 1 and 2 [PDF]

European Journal of Biochemistry, 1993
Mitogen‐activated protein‐kinase (MAP) kinase‐activated protein kinases 1 and 2 (MAPKAP kinase‐1, MAPKAP kinase‐2), were found to phosphorylate bacterially expressed human tyrosine hydroxylase in vitro at comparable rates to other proteins thought to be physiological substrates of these protein kinases.
Sutherland, Calum, Alterio, Janine, Campbell, David G., Le Bourdellès, Béatrice, Mallet, Jacques, Haavik, Jan, Cohen, Philip   +6 more
openaire   +3 more sources

Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners

Journal of Pharmacological Sciences, 2005
We found that striptease-positive mast cells were abundant in the invasive front of human colon adenocarcinoma by examining 30 cases. Because tryptase has been suggested to be the agonist proteinase for protease-activated receptor-2 (PAR-2), we ...
Masanori Yoshii, Atsushi Jikuhara, Shuji Mori, Hiromi Iwagaki, Hideo K. Takahashi, Masahiro Nishibori, Noriaki Tanaka   +6 more
doaj   +1 more source