MAP Kinase Kinase 6–p38 MAP Kinase Signaling Cascade Regulates Cyclooxygenase-2 Expression in Cardiac Myocytes In Vitro and In Vivo [PDF]
Circulation Research, 2003 Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in delayed prostaglandin biosynthesis. The purpose of this study was to evaluate the role of the MAP kinase kinase 6 (MKK6)–p38 MAPK signaling cascade in the regulation of myocardial COX-2 gene expression, in vitro and in vivo.
Chris Glembotski +2 more
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MAP kinase phosphatase 2 regulates macrophage-adipocyte interaction. [PDF]
PLoS ONE, 2015 Inflammation is critical for the development of obesity-associated metabolic disorders. This study aims to investigate the role of mitogen-activated protein kinase phosphatase 2 (MKP-2) in inflammation during macrophage-adipocyte interaction.White ...
Huipeng Jiao, Peng Tang, Yongliang Zhang
doaj +4 more sources
PLoS ONE, 2015 Arteriogenesis, the growth of natural bypass arteries, is triggered by hemodynamic forces within vessels and requires a balanced inflammatory response, involving induction of the chemokine MCP-1 and recruitment of leukocytes. However, little is known how
Anne Limbourg +10 more
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Frontiers in Microbiology, 2021 Mitogen-activated protein (MAP) kinase pathways function as signaling hubs that are integral for many essential cellular processes, including sexual development.
Nan Lan +12 more
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Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase [PDF]
Cell Research, 2010 The IκB kinase (IKK) complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the central activator of the NF-κB family of transcription factors. However, another important consequence of IKK activation is the regulation of TPL-2, a MEK kinase that is required for activation of ERK-1 ...
Thorsten, Gantke +2 more
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Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
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Erratum: Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase [PDF]
Cell Research, 2011 Correction to: (2011) 21:131-145. doi:10.1038/cr.2010.173; published online 7 December 2010 The authors apologize for incorrect citation of the work of Richard Lamb and colleagues on the regulation of TPL-2 by nutrient availability (page 137, top right column, reference 54). The correct reference for this research is:
Thorsten Gantke +2 more
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HAM-5 functions as a MAP kinase scaffold during cell fusion in Neurospora crassa. [PDF]
PLoS Genetics, 2014 Cell fusion in genetically identical Neurospora crassa germlings and in hyphae is a highly regulated process involving the activation of a conserved MAP kinase cascade that includes NRC-1, MEK-2 and MAK-2. During chemotrophic growth in germlings, the MAP
Wilfried Jonkers +8 more
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Feedback Regulation of Raf-1 and Mitogen-activated Protein Kinase (MAP) Kinase Kinases 1 and 2 by MAP Kinase Phosphatase-1 (MKP-1) [PDF]
Journal of Biological Chemistry, 1998 Inactivation of growth factor-regulated mitogen-activated protein (MAP) kinases (ERK1 and ERK2) has been proposed to occur in part through dephosphorylation by the dual specificity MAP kinase phosphatase-1 (MKP-1), an immediate early gene that is induced by mitogenic signaling.
P S, Shapiro, N G, Ahn
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Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. [PDF]
PLoS ONE, 2011 Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Docosahexaenoic acid (DHA), a representative ω-3 polyunsaturated fatty acid, has been reported to possess anti-inflammatory and chemopreventive ...
Mostafizur Rahman +4 more
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