Results 21 to 30 of about 288,019 (165)
Journal of Lipid Research, 2001 This study was conducted on human Jurkat T cell lines to elucidate the role of EPA and DHA, n-3 PUFA, in the modulation of two mitogen-activated protein (MAP) kinases, that is, extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2).
Anne Denys +2 more
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The MAP kinase‐activated protein kinase 2 contains a proline‐rich SH3‐binding domain [PDF]
FEBS Letters, 1993 The protein sequence of MAP kinase‐activated protein kinase 2 (MAPKAP kinase 2) deduced from mouse cDNA sequence reveals structural features of the enzyme, which could be of importance for its function: a proline‐rich SH3‐binding domain N‐terminal to the catalytic region, a MAP kinase phosphorylation site and a bipartite nuclear targeting sequence ...
Engel, Katrin +2 more
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Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells
Journal of Neuroinflammation, 2011 Background Peripheral-type benzodiazepine receptor (PBR) expression levels are low in normal human brain, but their levels increase in inflammation, brain injury, neurodegenerative states and gliomas.
Iida Hiroki, Kozawa Osamu, Tanabe Kumiko
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WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex
Frontiers in Microbiology, 2020 The formation of the fungal mycelial network is facilitated by somatic cell fusion of germinating asexual spores (or germlings). Neurospora crassa germlings in close proximity display chemotropic growth that is dependent upon an intracellular network of ...
A. Pedro Gonçalves +4 more
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Activating MAP KAP Kinase 2 [PDF]
Structure, 2003 AbstractThe crystal structures of MAP KAP kinase 2 in complex with ADP and staurosporine suggest a major reorganization of the glycine-rich loop upon ligand binding. The main determinant for the catalytic activity of MAP KAP kinase 2 is phosphorylation by p38 MAP kinase.
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Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice [PDF]
Circulation Research, 2007 Atherosclerosis is a chronic inflammatory disease and represents the major cause of cardiovascular morbidity and mortality. A critical regulator of inflammatory processes represents the mitogen-activated protein kinase–activated protein kinase-2 (MK2).
Jagavelu, Kumaravelu +5 more
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Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
RMD Open, 2019 Objectives We have previously shown mitogen-activated protein kinase phosphatase 2 (MKP-2) to be a key regulator of proinflammatory cytokines in macrophages.
Juliane Schroeder +9 more
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Frontiers in Cellular Neuroscience, 2017 The norepinephrine transporter (NET) mediates the clearance of norepinephrine (NE) from the extracellular space and is a target of therapeutic antidepressants and psychostimulants.
Ole V. Mortensen +2 more
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Journal of Lipid Research, 2000 The classic sterol regulatory cis element (sre-1) in the LDL receptor promoter mediates sterol regulatory element binding protein (SREBP)-binding and the effects of insulin and platelet derived growth factor (PDGF).
Jörg Kotzka +7 more
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The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2 [PDF]
Biochemical Journal, 1993 The substrate specificity of mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MAPKAP kinase-2) was investigated by using synthetic peptides related to the N-terminus of glycogen synthase. The minimum sequence required for efficient phosphorylation was found to be Xaa-Xaa-Hyd-Xaa-Arg-Xaa-Xaa-Ser-Xaa-Xaa, where Hyd is a bulky ...
Stokoe, D. +3 more
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