Results 41 to 50 of about 288,019 (165)

The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes [PDF]

Biochemical Journal, 1993
Incubation of human polymorphonuclear leucocytes (PMN) with either the chemotactic factor N-formylmethionyl-leucylphenylalanine (FMLP) or phorbol 12-myristate 13-acetate (PMA) activates a kinase with phosphorylating activity towards a known microtubule-associated protein-2 (MAP) kinase substrate, the epidermal growth factor receptor peptide (T669 ...
H L, Thompson, M, Shiroo, J, Saklatvala
openaire   +2 more sources

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase.

PLoS ONE, 2013
Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying
Antonio J Ruiz-Alcaraz, Christopher Lipina, John R Petrie, Michael J Murphy, Andrew D Morris, Calum Sutherland, Daniel J Cuthbertson   +6 more
doaj   +1 more source

Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development

Scientific Reports, 2022
Coordinating the balance between development and stress responses is critical for organismal survival. However, the cellular signaling controlling this mechanism is not well understood.
Rose Aria Malinow, Ming Zhu, Yishi Jin, Kyung Won Kim   +3 more
doaj   +1 more source

Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation

Journal of Lipid Research, 2006
Docosahexaenoic acid (DHA), a PUFA of the n-3 family, inhibited the growth of FM3A mouse mammary cancer cells by arresting their progression from the late-G1 to the S phase of the cell cycle.
Naim A. Khan, Kazuhiro Nishimura, Virginie Aires, Tomoko Yamashita, David Oaxaca-Castillo, Keiko Kashiwagi, Kazuei Igarashi   +6 more
doaj   +1 more source

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway

Cell Stress, 2021
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun, Karl Katholnig, Christopher Kaltenecker, Monika Linke, Nyamdelger Sukhbaatar, Markus Hengstschläger, Thomas Weichhart   +6 more
doaj   +1 more source

Pepsin-Digested Bovine Lactoferrin Induces Apoptotic Cell Death With JNK/SAPK Activation in Oral Cancer Cells

Journal of Pharmacological Sciences, 2005
Lactoferrin, a member of the transferrin family, is iron-binding and a strongly cationic 76 kDa glycoprotein. In breast milk it is secreted in high concentrations from glandular epithelia and is also present in other exocrine fluids including saliva.
Takayuki Sakai, Yoshiko Banno, Yukihiro Kato, Yoshinori Nozawa, Mitsuru Kawaguchi   +4 more
doaj   +1 more source

Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Molecular Pain, 2007
Background Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it is unclear whether SP regulates its own release from primary sensory neurons.
Arihiro Koji, Li Yu-Sang, Tang He-Bin, Nakata Yoshihiro   +3 more
doaj   +1 more source

A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway

Journal of Cell Communication and Signaling, 2020
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine-protein kinase belonging to the Ca2+/calmodulin-dependent protein kinase subfamily. CAMKK2 has an autocatalytic site, which gets exposed when Ca2+/calmodulin (CAM) binds to it. This results in autophosphorylation and complete activation of CAMKK2.
Mohd Altaf Najar, D. A. B. Rex, Prashant Kumar Modi, Nupur Agarwal, Shobha Dagamajalu, Gayathree Karthikkeyan, Manavalan Vijayakumar, Aditi Chatterjee, Uma Sankar, T. S. Keshava Prasad   +9 more
openaire   +3 more sources

From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors

Molecules, 2017
In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)-N-(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide.
Fabian Heider, Urs Haun, Eva Döring, Mark Kudolo, Catharina Sessler, Wolfgang Albrecht, Stefan Laufer, Pierre Koch   +7 more
doaj   +1 more source

Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase. [PDF]

PLoS ONE, 2013
The pathogenesis of interstitial cystitis/painful bladder syndrome (IC/PBS) is multifactorial, but likely involves urothelial cell dysfunction and mast cell accumulation in the bladder wall.
John O Marentette, Paul J Hauser, Robert E Hurst, David J Klumpp, Alice Rickard, Jane McHowat   +5 more
doaj   +1 more source