Results 61 to 70 of about 288,019 (165)

Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-Activated Protein Kinases

Journal of Pharmacological Sciences, 2003
Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective.
Masanori Yoshizumi, Jun-ichi Abe, Koichiro Tsuchiya, Bradford C. Berk, Toshiaki Tamaki   +4 more
doaj   +1 more source

Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK during Toxoplasma gondii invasion

Parasite, 2003
Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T.
Valère A., Garnotel R., Villena I., Guenounou M., Pinon J.M., Aubert D.   +5 more
doaj   +1 more source

Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways

Journal of Neuroinflammation, 2011
Tuberculosis (TB) of the central nervous system (CNS) is a deadly disease characterized by extensive tissue destruction, driven by molecules such as Matrix Metalloproteinase-2 (MMP-2) which targets CNS-specific substrates.
Elkington Paul T, Fry Julie, Moores Rachel, Ong Catherine WM, Janczar Karolina, Dholakia Shruti, Green Justin A, Roncaroli Federico, Friedland Jon S   +8 more
doaj   +1 more source

The MK2 pathway is linked to G-CSF, cytokine production and metastasis in gastric cancer: a novel intercorrelation analysis approach

Journal of Translational Medicine, 2020
Background Gastric cancer is associated with chronic inflammation, but there is still much to understand about the tumor microenvironment and the underlying tumor-promoting mechanisms.
Fares Qeadan, Pranshu Bansal, Joshua A. Hanson, Ellen J. Beswick   +3 more
doaj   +1 more source

Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans

Neural Development, 2007
Background The left and right AWC olfactory neurons in Caenorhabditis elegans differ in their functions and in their expression of chemosensory receptor genes; in each animal, one AWC randomly takes on one identity, designated AWCOFF, and the ...
Katsura Isao, Ishihara Takeshi, Torayama Ichiro, VanHoven Miri K, Saheki Yasunori, Bauer Huang Sarah L, van der Linden Alexander, Sengupta Piali, Bargmann Cornelia I   +8 more
doaj   +1 more source

The genetic landscape of ganglioglioma

Acta Neuropathologica Communications, 2018
Ganglioglioma is the most common epilepsy-associated neoplasm that accounts for approximately 2% of all primary brain tumors. While a subset of gangliogliomas are known to harbor the activating p.V600E mutation in the BRAF oncogene, the genetic ...
Melike Pekmezci, Javier E. Villanueva-Meyer, Benjamin Goode, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Boris C. Bastian, Gabriel Chamyan, Ossama M. Maher, Ziad Khatib, Bette K. Kleinschmidt-DeMasters, David Samuel, Sabine Mueller, Anuradha Banerjee, Jennifer L. Clarke, Tabitha Cooney, Joseph Torkildson, Nalin Gupta, Philip Theodosopoulos, Edward F. Chang, Mitchel Berger, Andrew W. Bollen, Arie Perry, Tarik Tihan, David A. Solomon   +24 more
doaj   +1 more source

CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms

Frontiers in Endocrinology, 2019
In the present study, we determined the cellular regulators of ERK1/2 and Akt signaling pathways in response to human CRF1 receptor (CRF1R) activation in transfected COS-7 cells.
G. Karina Parra-Mercado, Alma M. Fuentes-Gonzalez, Judith Hernandez-Aranda, Monica Diaz-Coranguez, Frank M. Dautzenberg, Kevin J. Catt, Richard L. Hauger, Richard L. Hauger, J. Alberto Olivares-Reyes   +8 more
doaj   +1 more source

Proteinase-Activated Receptor-2–Triggered Prostaglandin E2 Release, but Not Cyclooxygenase-2 Upregulation, Requires Activation of the Phosphatidylinositol 3–Kinase / Akt / Nuclear Factor-κB Pathway in Human Alveolar Epithelial Cells

Journal of Pharmacological Sciences, 2009
Proteinase-activated receptor-2 (PAR2) triggers upregulation of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) formation in human alveolar epithelial A549 cells.
Kazumi Moriyuki, Fumiko Sekiguchi, Kaori Matsubara, Hiroyuki Nishikawa, Atsufumi Kawabata   +4 more
doaj   +1 more source

Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L

Cell Reports
Summary: RNase L is an endoribonuclease of higher vertebrates that functions in antiviral innate immunity. Interferons induce oligoadenylate synthetase enzymes that sense double-stranded RNA of viral origin leading to the synthesis of 2′,5 ...
Jiajia Xi, Goda Snieckute, José Francisco Martínez, Frederic Schrøder Wenzel Arendrup, Abhishek Asthana, Christina Gaughan, Anders H. Lund, Simon Bekker-Jensen, Robert H. Silverman   +8 more
doaj   +1 more source

Emerging modes of PINK1 signaling: another task for MARK2

Frontiers in Molecular Neuroscience, 2014
PTEN-induced kinase 1 (PINK1) acts at multiple levels to promote mitochondrial health, including regulatory influence on ATP-synthesis, protein quality control, apoptosis, mitochondrial transport and destiny.
Dorthe eMatenia, Eva Maria eMandelkow, Eva Maria eMandelkow   +2 more
doaj   +1 more source