Activity-based chemoproteomic profiling reveals the active kinome of Leishmania [PDF]
Frontiers in PharmacologyBackgroundLeishmania parasites cause neglected tropical diseases such as cutaneous and visceral leishmaniasis, which have limited treatment options and rising drug resistance. Protein kinases are pivotal in Leishmania biology and attractive drug targets,
Exequiel O. J. Porta +3 more
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Staphylococcal PknB as the first prokaryotic representative of the proline-directed kinases. [PDF]
PLoS ONE, 2010 In eukaryotic cell types, virtually all cellular processes are under control of proline-directed kinases and especially MAP kinases. Serine/threonine kinases in general were originally considered as a eukaryote-specific enzyme family.
Malgorzata Miller +12 more
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Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
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MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites
FEBS Open Bio, 2022 Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of l‐arginine to nitric oxide (NO) in response to a significant number of signaling pathways.
Xzaviar K. V. Solone +9 more
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A subcellular map of the human kinome
eLife, 2021 The human kinome comprises 538 kinases playing essential functions by catalyzing protein phosphorylation. Annotation of subcellular distribution of the kinome greatly facilitates investigation of normal and disease mechanisms.
Haitao Zhang +21 more
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The NDR kinase scaffold HYM1/MO25 is essential for MAK2 map kinase signaling in Neurospora crassa. [PDF]
PLoS Genetics, 2012 Cell communication is essential for eukaryotic development, but our knowledge of molecules and mechanisms required for intercellular communication is fragmentary.
Anne Dettmann +5 more
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Mitogen-activated protein kinases are associated with the regulation of physiological traits and virulence in Fusarium oxysporum f. sp. cubense. [PDF]
PLoS ONE, 2015 Fusarium oxysporum f. sp. cubense (FOC) is an important soil-borne fungal pathogen causing devastating vascular wilt disease of banana plants and has become a great concern threatening banana production worldwide.
Zhaojian Ding +6 more
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Journal of Inflammation, 2006 Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
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c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
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Function of MAP kinases in plant signal transduction pathway networks
浙江大学学报. 农业与生命科学版, 2004 Mitogen-activated protein kinase (MAPK) cascade, which consists of three Ser/Thr protein kinases, namely, MAP kinase kinase kinase, MAP kinase kinase and MAP kinase, is a universal module in signal transduction pathways in all eukaryotes.
SONG Dong-hui +2 more
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