Results 211 to 220 of about 288,292 (262)

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Multi-omics analysis reveals <i>Rheum-Salvia miltiorrhiza</i> alleviates cisplatin-induced acute kidney injury via gut-kidney axis-mediated MAPK signaling pathway. [PDF]

Front Pharmacol
Zhang Y, Liu S, Li X, Zhou Y, Wu X, Yang H, Che M, Lei X, Laghari I, Wu M, Han R, Liu H, Zhou Z, Peng G, Zhang K, Zhong Z.   +15 more
europepmc   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

The metformin mediated MAPK signaling pathway influences D-Xylose regulation during diabetic kidney disease therapy. [PDF]

Commun Med (Lond)
Xie D, Zhu Y, Guo S, Li H, Wang Z, Wang X, Cai Y, Chai J, Wang Y, Hu Z, Wang S, Chen L, Qiu S, Xie Y, Zhang A.   +14 more
europepmc   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Rivaroxaban Ameliorates Sunitinib-Induced Injury of Cardiomyocytes via Repressing MAPK Signaling Pathway. [PDF]

Cardiovasc Ther
Qian Y, Yi F.
europepmc   +1 more source

Linoelaidic acid alleviates COM-induced kidney injury and crystal deposition via the PPARγ/MAPK signaling pathway. [PDF]

Urolithiasis
Qi W, Yan X, Li C, Jing J, Zhang Y, Xi J, Liang C.   +6 more
europepmc   +1 more source

CDK12 inhibition enhances oxaliplatin efficacy in gastric cancer by suppressing the MAPK signaling pathway. [PDF]

J Gastrointest Oncol
Huang D, Xiong Z, Zhong B, Li X, Mohamed SA, Sun J, Xu H, Guo J, Deng Z, Li X, Almhanna K, Chen Y, Lian L.   +12 more
europepmc   +1 more source

Effects of Mytilus edulis derived plasmalogens against atherosclerosis via lipid metabolism and MAPK signaling pathway. [PDF]

NPJ Sci Food
Feng J, Zhang J, Wang S, Li Z, Yuan H, Yao H, Xue J, Zheng J, Wu Y, Wang S, Zeng X, Cui Y, Tang O, Cheng K, Shen Q.   +14 more
europepmc   +1 more source

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]

Cancers, 2021
Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF ...
Hyuk Moon, Simon Weonsang Ro, Moon Hyuk   +2 more
exaly   +3 more sources